Clinical and Diagnostic Patterns of Leishmaniasis in the Dog

Pugliese, A.; Pietro, Simona Di; Giudice, Elisabetta

doi:10.1007/s11259-006-0009-9

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Clinicopathological features of CVL can vary widely in dogs, and the long incubation period, coupled with the chronic nature of CVL, may generate a delay or failure in clinical diagnosis (Ciaramella et al 1997;Lamothe 1997;Koutinas et al 1999;Blavier et al 2001;Pugliese et al 2006). This retrospective study demonstrated that CVL, with usual and unusual clinicopathological findings, was a variably presenting disease.…”

Section: Discussionmentioning

confidence: 73%

An immunohistochemical study in cases with usual and unusual clinicopathological findings of canine visceral leishmaniosis

Toplu

Aydoğan

2011

Parasitol Res

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The present study describes pathologic findings and immunohistochemical diagnosis of canine visceral leishmaniasis (CVL) in 22 dogs who died naturally in the Aegean region of Turkey. At necropsy, lymphadenomegaly, hepatosplenomegaly, hepatic, and nephrosclerotic lesions were conspicuous. Histopathologically, chronic inflammatory reactions of the spleen, lymph nodes, bone marrow, liver, and skin were marked findings. Cytological and histological examinations showed macrophages loaded with Leishmania amastigotes in these organs. Immunohistochemistry revealed that immunolabeling of amastigotes and/or parasite antigen, especially in the lymph nodes, spleen, bone marrow, liver, and skin, and occasionally, in the kidneys, intestines and lungs. Our laboratory results showed that immunohistochemistry should be included, along with cytological and histological examinations, in the diagnosis of CVL.

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Section: Discussionmentioning

confidence: 73%

An immunohistochemical study in cases with usual and unusual clinicopathological findings of canine visceral leishmaniosis

Toplu

Aydoğan

2011

Parasitol Res

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“…Such changes were previously described [ 59 , 65 , 66 ] and could be caused by the action of the parasite [ 67 ] or could be the result of a potential renal failure (uremic state) [ 65 , 66 ]. Seemingly, the petechiae and hemorrhagic suffusions detected in the stomach of the same dog could be the result of hemostatic disorders usually associated with CanL [ 67 ] or due to a possible uremic state. Histopathology of the kidney revealed a renal infarction and subchronic membranoproliferative glomerulonephritis.…”

Section: Discussionmentioning

confidence: 98%

Canine Leishmaniasis in Morocco: A Descriptive Prospective Clinical Study

Idrissi

Hakkour

Duchateau

et al. 2021

Veterinary Medicine International

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Canine leishmaniasis (CanL) is a zoonotic vector-borne disease that is endemic in the Mediterranean Basin including Morocco. Dogs play a major epidemiological role in this zoonosis as reservoir hosts. This study investigated the clinical manifestations of CanL in dogs naturally infected with Leishmania infantum. A total of 96 dogs presented to the Small Animal Clinic of the Hassan II Agronomy and Veterinary Institute (IAV Hassan II) of Rabat, Morocco, and were tested by RT-PCR and/or serology. Among them, 32 (33.3%) were positive to Leishmania infantum infection. The majority of the positive dogs (93.7%) came from urban areas. Most of them were male (62.5%) and purebreds (65.6%), were aged between 3 and 7 years (71.8%), and had outside activities (guarding, hunting, livestock guarding, and service activities) (71.8%) and all of them were living exclusively outdoor or had free access to the outdoor environment. Lymphadenomegaly (81.2%), dermatological disorders (65.6%) (mostly exfoliative dermatitis), weight loss (59.3%), exercise intolerance (56.2%), anorexia (28.1%), hyporexia (15.6%), and ocular lesions (28.1%) were the most frequent clinical signs and complaints recorded. Anemia and hyperproteinemia due to hyperglobulinemia were observed in 68.7% and 72.7% of the cases, respectively. These results suggest that CanL leads to various nonspecific clinical signs as described previously, making the diagnosis challenging. Since CanL is endemic in Morocco, it should be recommended to systematically test dogs displaying clinical signs compatible with this disease and to regularly screen asymptomatic at-risk dogs. It is also crucial to educate dog owners about the zoonotic aspect of the disease and to encourage intersectorial collaboration following the “One Health” concept, in order to contribute to a more effective control/prevention of human and canine leishmaniasis.

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“…A variety of infectious diseases can affect the dogs and their adverse effects on health have been repeatedly documented [1][2][3]. Canine parvovirus (CPV) causes a very common worldwide diffused infectious disease in dogs.…”

Section: Introductionmentioning

confidence: 99%

Investigation on Canine parvovirus circulation in dogs from Sicily (Italy) by biomolecular assay

et al. 2018

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Canine parvovirus type-2 (CPV-2) is a DNA virus that causes a very common worldwide diffused infectious disease in dogs. Since its appearance, the CPV-2 evolved generating novel genetic and antigenic variants (CPV-2a/2b/2c) which are distributed throughout the world. In the present study, the frequency of CPV-2 in a canine population in Sicily (Italy) was investigated, using a polymerase chain reaction (PCR) for a fragment of the VP2 gene. Out of a total of 673 samples from 370 dogs, submitted to the laboratory from July 2009 to August 2015, 265 samples (39.38%) were positive and these were further analyzed by restriction fragment length polymorphism (RFLP) and DNA sequence analysis. A high prevalence of the CPV-2c variant (79.56% of CPV-2 positive dogs) was observed in this survey, underlining that this type of CPV field isolate is prevalent circulating in Sicily. Sequence and phylogenetic analysis showed a close relationship with CPV-2a and CPV-2c strains from Europe and non-European countries. Considering that CPV-2c is reaching a worldwide distribution and that this variant is also affecting vaccinated dogs, efforts should be made towards the development of new CPV vaccines.

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Clinical and Diagnostic Patterns of Leishmaniasis in the Dog

Cited by 4 publications

References 12 publications

An immunohistochemical study in cases with usual and unusual clinicopathological findings of canine visceral leishmaniosis

An immunohistochemical study in cases with usual and unusual clinicopathological findings of canine visceral leishmaniosis

Canine Leishmaniasis in Morocco: A Descriptive Prospective Clinical Study

Investigation on Canine parvovirus circulation in dogs from Sicily (Italy) by biomolecular assay

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