Clinical and dermoscopic features of surgically treated melanocytic nevi

Abstract

Background:Compared with Caucasians, unique demographic and clinical features have been reported in Chinese patients with malignant melanoma, but similar comparative studies of melanocytic nevi (MN) are lacking. This study examined the clinical and dermoscopic features of MN in surgically treated Chinese cases.Methods:Clinical data and dermoscopic findings from 1046 cases of MN were collected and analyzed. Cases were treated from January 1 to December 31, 2014 at the Department of Dermatology and Venerology, Peking University First Hospital. The association between nevi location and histologic subtypes was examined with Chi-squared test and univariate logistic regression. Chi-squared test was also used to analyze the proportion of globular patterns across different body sites, and proportion of parallel furrow patterns across different histologic subtypes.Results:The majority of the nevi were from female patients, irrespective of location. The range of age at the time of nevi onset was from 0 (birth) to 79 years. There were 381 (36.4%, 381/1046) congenital nevi; of these 81.6% (311/381) were present at birth. Nevi appeared before 30 years of age in 83.2% (870/1046) of the cases. Median values of length growth rate in congenital and acquired MN were 2.0 and 1.6, respectively. Median values of length growth rates in four age groups (0–9, 10–19, 20–29, and ≥30 years) of congenital nevi were 2.2, 2.0, 2.4, and 2.0, respectively. In acral nevi, which often need to be differentiated from acral lentiginous melanoma, 50.2% (109/217) were junctional (odds ratio [OR]; 95% confidence interval [CI]: 91.572 [52.210–160.959], P < 0.05). Acral location was also associated with a higher likelihood of compound nevi subtype (OR [95% CI]: 14.468 [8.981–23.306], P < 0.05). The globular (59.4%, 354/596) and pseudonetwork (48.8%, 291/596) dermoscopic patterns were often seen in the head and neck region. In areas other than head and neck and acral regions, the globular pattern was the commonest pattern (34.8%, 71/204) regardless of age. Parallel furrow pattern occurred in 46.0% (87/189) of acral MN, followed by fibrillar pattern (21.7%, 41/189).Conclusion:Unique clinical and dermoscopic features exist in Chinese patients with MN compared with observations reported in other population.

A comparative study of melanocytic nevi classification with dermoscopy and high‐frequency ultrasound

“…In this study, we compared the HF‐US and dermoscopic evaluation of MN in subtype differentiation for the first time and proved that these two methods had a good consistency, implying that the combination of them could provide accurate and objective information for MN classification from both vertical and horizontal perspectives. MN have been reported as the most frequently surgically treated neoplasm at the department of dermatology of a tertiary university hospital in China 13 . Even with the help of dermoscopy, the accurate classification of MN subtypes remains a clinical challenge sometimes depending merely on clinical and dermoscopic criteria.…”

“…MN have been reported as the most frequently surgically treated neoplasm at the department of dermatology of a tertiary university hospital in China. 13 Even with the help of dermoscopy, the accurate classification of MN subtypes remains a clinical challenge sometimes depending merely on clinical and dermoscopic criteria. However, to clarify the actual subtypes of MN is meaningful for selecting management strategies, and broadening the understanding of HF‐US manifestation of MN could help dermatologists to differentiate it from other diseases such as melanoma.…”

Figura 2: Análise multivariada de agrupamento cluster para verificar a similaridade da localização anatômica nos nervos Juncionais, Compostos e Intradermicos, com coeficiente de Bray-Curtis de 0,8718.

“…Os resultados do presente estudo demonstraram que nevos compostos estiveram associados a pacientes com idade mais jovem e nevos intradérmicos apresentam distribuição anatômica mais dissimilar que os demais nevos analisados. Diferentemente de resultados do presente estudo, Krengel et al (2) destacou associação dos nevos juncionais com idade mais jovem enquanto Li et al (4) e Wang et al (5) identificaram associação desses nevos com os sítios acrais. Em conformidade com Li et al (3) os nevos intradérmicos foram mais frequentes na região de cabeça e pescoço.…”

Hubungan Tingkat Ekspresi P15 Terhadap Nevus Melanositik Dan Melanoma Maligna

“…Hasil ini sejalan dengan penelitian Li dkk pada tahun 2019 yang melibatkan 1046 pasien nevus melanositik, didapatkan persentase pasien nevus melanositik dengan jenis kelamin perempuan (70,5%) lebih banyak dibandingkan laki-laki. 19 Penelitian lain yang dilakukan Ghosh et al dkk pada tahun 2018 juga mendapatkan persentase pasien nevus melanositik dengan jenis kelamin perempuan (65%) lebih banyak dibandingkan laki-laki. 1 Hal ini mungkin disebabkan oleh faktor hormonal.…”