Clinical and dermoscopic features of atypical Spitz tumors: A multicenter, retrospective, case-control study

Moscarella, Elvira; Lallas, Aimilios; Kyrgidis, Athanassios; Ferrara, Gerardo; Longo, Caterina; Scalvenzi, Massimiliano; Staibano, Stefania; Carrera, Cristina; Diaz, Marina; Broganelli, Paolo; Tomasini, Carlo Francesco; Cavicchini, S.; Gianotti, Raffaele; Puig, Susana; Malvehy, Josep; Zaballos, Pedro; Pellacani, Giovanni; Argenziano, Giuseppe

doi:10.1016/j.jaad.2015.08.018

Cited by 49 publications

(56 citation statements)

References 26 publications

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“…The most common vascular abnormality observed in all examined patients were dotted vessels (23/68, 33.8%), followed by linear serpentine vessels (16/68, 23.5%). Dotted vessels were previously described in psoriasis, Spitz nevi, and melanoma . In our study, they occurred in 13/26 (50.0%) patients with PV, 2/17 (11.8%) patients with PF, 3/17 (33.8%) patients with BP, and 5/8 (62.5%) patients with DH (Kruskal–Wallis test, P = 0.01).…”

Section: Commentsupporting

confidence: 65%

Trichoscopy – a useful tool in the preliminary differential diagnosis of autoimmune bullous diseases

2017

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Section: Commentsupporting

confidence: 65%

Trichoscopy – a useful tool in the preliminary differential diagnosis of autoimmune bullous diseases

2017

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“…As shown in Table , 15 eligible studies were finally included in the data synthesis. The 15 eligible studies included six multicentre case–control studies, three single‐centre case–control studies, one multicentre case series study and five single‐centre case series studies …”

Section: Resultsmentioning

confidence: 99%

“…With respect to ASTs, a recent study investigated dermoscopic findings in a series of 55 ASTs compared with 110 Spitz naevi . According to the results, the vast majority of ASTs are dermoscopically typified by a multicomponent pattern and would thus be clinically interpreted as suspicious for melanoma.…”

Section: Discussionmentioning

confidence: 99%

Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society

et al. 2017

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Spitzoid lesions represent a challenging and controversial group of tumours, in terms of clinical recognition, biological behaviour and management strategies. Although Spitz naevi are considered benign tumours, their clinical and dermoscopic morphological overlap with spitzoid melanoma renders the management of spitzoid lesions particularly difficult. The controversy deepens because of the existence of tumours that cannot be safely histopathologically diagnosed as naevi or melanomas (atypical Spitz tumours). The dual objective of the present study was to provide an updated classification on dermoscopy of Spitz naevi, and management recommendations of spitzoid-looking lesions based on a consensus among experts in the field. After a detailed search of the literature for eligible studies, a data synthesis was performed from 15 studies on dermoscopy of Spitz naevi. Dermoscopically, Spitz naevi are typified by three main patterns: starburst pattern (51%), a pattern of regularly distributed dotted vessels (19%) and globular pattern with reticular depigmentation (17%). A consensus-based algorithm for the management of spitzoid lesions is proposed. According to it, dermoscopically asymmetric lesions with spitzoid features (both flat/raised and nodular) should be excised to rule out melanoma. Dermoscopically symmetric spitzoid nodules should also be excised or closely monitored, irrespective of age, to rule out atypical Spitz tumours. Dermoscopically symmetric, flat spitzoid lesions should be managed according to the age of the patient. Finally, the histopathological diagnosis of atypical Spitz tumour should warrant wide excision but not a sentinel lymph-node biopsy.

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“…) . When a starburst pattern is detected in adults, histopathological examination is encouraged to exclude Spitzoid melanoma …”

Section: Dermoscopic Mimics Of Skmentioning

confidence: 99%

Dermoscopy–pathology relationship in seborrheic keratosis

Minagawa

2017

The Journal of Dermatology

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Making a definitive diagnosis of seborrheic keratosis (SK) can be challenging for the naked eye due to its wide variation in clinical features. Fortunately, however, most cases of SK exhibit the typical dermoscopic findings of fissures and ridges, hairpin vessels with white halo, comedo-like openings, and milia-like cysts, all of which are helpful to distinguish SK from melanoma, melanocytic nevus, squamous cell carcinoma, basal cell carcinoma (BCC) and other skin tumors. Histopathologically, these dermoscopic characteristics correspond to papillomatous surface of the epidermis, enlarged capillaries of the dermal papillae, pseudohorn cysts in the epidermis opened to the surface of the lesion and intraepidermal cysts, respectively. Clinicians should bear in mind that the clonal type of SK dermoscopically mimics melanoma and BCC by the presence of globule-like structures, while regressing SK exhibits a granular pattern that is similar to the peppering found in melanoma. Furthermore, milia-like cysts alone are insufficient for a conclusive diagnosis of SK because melanoma in rare cases displays cysts along with other SK-like dermoscopic findings.

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Clinical and dermoscopic features of atypical Spitz tumors: A multicenter, retrospective, case-control study

Cited by 49 publications

References 26 publications

Trichoscopy – a useful tool in the preliminary differential diagnosis of autoimmune bullous diseases

Trichoscopy – a useful tool in the preliminary differential diagnosis of autoimmune bullous diseases

Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society

Dermoscopy–pathology relationship in seborrheic keratosis

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