Clinical and dermoscopic characterization of pediatric Spitz nevi of the ear

Vaccaro, Mario; Marafioti, Ilenia; Giuffrida, Roberta; Borgia, Francesco; Zalaudek, Iris

doi:10.1111/pde.14616

Cited by 4 publications

(8 citation statements)

References 17 publications

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“…These nests are usually defined by peripheral crescent-shaped clefts, and even lone epidermal melanocytes may be delimited [3]. Kamino bodies, eosinophilic blood cells comprising basal membrane material, are often present within the epidermis [11, 12]. In the case of nevi of the nail matrix, these are almost always junctional, as in the presented patient [2].…”

Section: Discussionmentioning

confidence: 99%

Atypical Presentation of Spitz Nevus: A Case Report

Araiza-Atanacio,

Venegas-Andrade,

Toussaint-Caire

et al. 2023

Skin Appendage Disord

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Introduction: The Spitz nevus (SN) is an acquired melanocytic neoplasm composed of epithelioid and/or spindle cells, which tends to develop in childhood. In pediatric patients, it is usually located on the face and neck. Unusual locations have been found in the literature, such as the penis, mouth, and tongue, as well as 2 cases of ungual SN. Case Report: A 15-year-old male evaluated for dark brown-black longitudinal melanonychia that covered 40% of the nail, with pseudo-Hutchinson’s sign, of 1 year of evolution. Discussion: The SN accounts for 1% of the melanocytic neoplasms. In the present paper, we show the third case of ungual SN never previously disclosed, which presents a zigzag pattern reported in the literature for its association with the pediatric population.

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Section: Discussionmentioning

confidence: 99%

Atypical Presentation of Spitz Nevus: A Case Report

Araiza-Atanacio,

Venegas-Andrade,

Toussaint-Caire

et al. 2023

Skin Appendage Disord

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“…Considerable overlap exists between malignant and benign dermatoscopic features in spitzoid lesions, 14-17 especially in ear lesions, that tend to have clinical and dermatoscopic irregularities due to the anatomic morphology of this special site. 4 …”

Section: Discussionmentioning

confidence: 99%

“…Spitzoid lesions represent a challenging dermatological entity, as they comprise benign Spitz nevi (SN), malignant melanoma (MM), and melanocytic proliferations with intermediate features between melanoma and nevus, the so-called atypical Spitz tumors (AST). [1][2][3][4] The differential diagnosis of these spitzoid entities is clinically as well as histopathologically challenging, particularly at special body sites such as the ear, mucosae, and acral skin, where microanatomic diversity influences skin morphology. 4 While dermatoscopy was suggested as a diagnostic tool to avoid excision of well-recognized benign lesions, on special body sites such as the ear, clinical-dermatoscopic aspects may not correspond to histological characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] The differential diagnosis of these spitzoid entities is clinically as well as histopathologically challenging, particularly at special body sites such as the ear, mucosae, and acral skin, where microanatomic diversity influences skin morphology. 4 While dermatoscopy was suggested as a diagnostic tool to avoid excision of well-recognized benign lesions, on special body sites such as the ear, clinical-dermatoscopic aspects may not correspond to histological characteristics. Moreover, spitzoid ear lesions are rare and therefore seldom reported in the literature, hindering the development of consensus guidelines on the management and treatment of these lesions.…”

Section: Introductionmentioning

confidence: 99%

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Pediatric spitzoid lesions of the ear: a single center experience and review of literature

et al. 2023

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Background and objectives. Spitzoid lesions are challenging melanocytic lesions comprising benign, intermediate, and malignant lesions. In this study, we aimed to analyze the diagnostic accuracy of clinical and dermatoscopical evaluation of pediatric spitzoid ear lesions. Materials and Methods. We collected and analyzed, clinically, dermatoscopically and histologically, pediatric spitzoid ear lesions. Also, we conducted a systematic review of literature. Results. At the Pediatric Hospital Gaslini, excision and histopathological evaluation were performed on eight cases: 87.5% of lesions were consistent with Spitz nevus (SN), and 12.5% with atypical Spitz tumor AST. Notably, multiple (≥2) dermatoscopical irregularities were present in five of seven SN (71%), yet none were found in AST 0/1 (0%). (Fisher’s exact test p=0.375). From systematic research of the literature, 9 patients were included in this review. At histology, 88.9% were SN, and 11% AST. Of note, also in literature, multiple dermatoscopical irregularities, were present in most SN (75%, 6/8), not in the identified AST (0%, 0/1) (p=0.3333). Conclusions. We present a monocentric study on pediatric spitzoid ear lesions. Importantly, dermatoscopical irregularities were not significantly associated to AST, neither in our series, nor in the reviewed literature (respectively p=0.375 and p=0.3333) supporting the fact that relying only on the dermatoscopical aspect of spitzoid lesions is not accurate enough for the special site of the ear, where dermatoscopy could be actually misleading.

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“…Special sites, such as the ear, appear rarely and raise a challenge with distinct features. 1 In clinical, tan-black macules/plaques of pigmented SNs account for the large majority of excised SNs (79.5%), while pink-red nodular SNs with a dotted/polymorphous vascular pattern are rare (4.8%). 2,3 The clinicopathologic definition "red Spitz tumors" raises as opposite to the "blue Spitz tumors".…”

Section: Introductionmentioning

confidence: 99%

“Red Spitz Tumor” on the Ear: Case Report and Review of the Literature

Liang¹,

Yu²,

Li³

et al. 2022

CCID

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Spitz nevus (SN) is a benign melanocytic lesion with cytologic and architectural atypia. It is sometimes difficult to distinguish SNs from atypical Spitz tumor (AST), Spitz melanoma, or conventional melanoma. SNs frequently develop in Caucasians and appear on the skin of the head and lower extremities. Lesions on the ear in Asian populations are rare. Here, we report a "red Spitz tumor" on the ear of a Chinese 18year-old boy. Dermoscopic examination revealed possibly malignant features presented as polymorphous vessels along with central white area, pseudo-network depigmentation and atypical peripheral globular pattern. The results of histopathological examination strongly suggested that the neoplasm was a compound SN and no recurrences or metastases occurred during 1-year follow-up post-surgery. Further, we review the literature on 4 previously reported cases of SN on the ear and summarize the main points of SN diagnosis and differential diagnosis with atypical Spitz tumors and melanoma.

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Clinical and dermoscopic characterization of pediatric Spitz nevi of the ear

Cited by 4 publications

References 17 publications

Atypical Presentation of Spitz Nevus: A Case Report

Atypical Presentation of Spitz Nevus: A Case Report

Pediatric spitzoid lesions of the ear: a single center experience and review of literature

“Red Spitz Tumor” on the Ear: Case Report and Review of the Literature

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