Clinical and Demographic Characteristics of Tearing in Patients after Radioiodine Ablation for Differentiated Thyroid Cancer

Yartsev, V.D.; Солодкий, В. А.; Фомин, Д. К.; Борисенко, Т. Е.; Atkova, E.L.

doi:10.1080/02713683.2021.1878229

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…According to the study, SALDO occurs in 8.8% of patients after a single high-dose radioactive iodine therapy, and the probability of the complication is multiplied during repeated treatment [3]. The analysis of the lacrimal sac and nasolacrimal duct biopsies revealed the expression of Na + /Isymporter (NIS) in these structures which may be the biochemical basis for the development of SALDO [4].…”

Section: Discussionmentioning

confidence: 99%

Morphological Characteristics of the Lacrimal Apparatus in its Obstruction of Various Genesis

Demyashkin

Yartsev

Atkova

et al. 2023

Indian J Otolaryngol Head Neck Surg

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Purpose: morphological assessment of the lacrimal ducts at various anatomical levels in patients with primary (PANDO) and secondary (SALDO) obstruction after radioactive iodine therapy.Methods. The material was obtained during endoscopic dacryocystorinostomy with revision of Hasner's valve in patients with PANDO (n=7) in the distal segments of the nasolacrimal duct and in patients with SALDO (n=7) after radioactive iodine therapy. During the surgery, a biopsy of Hasner's valve, as well as a biopsy of the lacrimal sac wall were performed. The resulting material was stained with hemotoxylin and eosin, alcyan blue and by Masson method. Morphological and morphometric analyses were performed in semi-automatic mode. The results of histochemical staining of sections were translated into points taking into account the area and optical density (chromogenicity) in relative units: 1 -weak (0 -0.3); 2moderate (0.3 -0.6); 3 -signi cant (>0.6). The nonparametric Mann-Whitney criterion was used for statistical analysis. The differences were considered signi cant at p<0.05.Results. The comparative morphological study both con rmed the available information concerning the radiation nature of the obstruction and allowed to quantify the brosis level of the stromal component and other lacrimal ducts structures.Conclusion. It was shown that the nasolacrimal duct sclerosis is signi cantly lower (p=0.029) in patients with SALDO than in patients with PANDO while brosis in the lacrimal sac is the same in patients of the compared groups.

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Section: Discussionmentioning

confidence: 99%

Morphological Characteristics of the Lacrimal Apparatus in its Obstruction of Various Genesis

Demyashkin

Yartsev

Atkova

et al. 2023

Indian J Otolaryngol Head Neck Surg

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“…da Fonseca et al 60 compared the incidence of tear drainage disorders in the patients with thyroid cancer who received and did not receive radioiodine therapy and showed that in the patients after such treatment, the incidence of tear ducts narrowing was 6.8% of cases unlike in the patients of the control group. A telephone survey of patients after radioiodine therapy showed significant tearing in 9% of patients, whereas this symptom frequency increased many times with repeated radioiodine therapy 56 …”

Section: Radioiodine Iodine-131mentioning

confidence: 99%

Nasolacrimal Duct Obstruction in the Patients Receiving Treatment for Cancer

Yartsev

Atkova

2023

International Ophthalmology Clinics

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“…или позднее[8,[11][12][13][14].Описаны случаи развития вторичной облитерации слезоотводящих путей, возникающей в отдаленные сроки (более 6 мес.) после радиойодтерапии[15][16][17][18][19][20][21]. Анализ распространенности этого состояния у пациентов показал, что облитерация слезоотводящих путей развивается в 8% случаев после однократной радиойодтерапии[20].…”

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“…после радиойодтерапии[15][16][17][18][19][20][21]. Анализ распространенности этого состояния у пациентов показал, что облитерация слезоотводящих путей развивается в 8% случаев после однократной радиойодтерапии[20]. В литературе есть указания на некоторые факторы, ассоциированные с возрастанием риска развития вторичной облитерации слезоотводящих путей после радиойодтерапии, однако эти сведения разрознены, а система стратификации риска на сегодняшний день не разработана.…”

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Nasolacrimal Duct Obstruction Secondary to Radioactive Iodine-131 Therapy for Differentiated Thyroid Cancer

Трухин

Yartsev

Sheremeta³

et al. 2022

Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr

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Clinical and Demographic Characteristics of Tearing in Patients after Radioiodine Ablation for Differentiated Thyroid Cancer

Cited by 10 publications

References 13 publications

Morphological Characteristics of the Lacrimal Apparatus in its Obstruction of Various Genesis

Morphological Characteristics of the Lacrimal Apparatus in its Obstruction of Various Genesis

Nasolacrimal Duct Obstruction in the Patients Receiving Treatment for Cancer

Nasolacrimal Duct Obstruction Secondary to Radioactive Iodine-131 Therapy for Differentiated Thyroid Cancer

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