Clinical and Demographic Characteristics of Patients with COVID-19 Who Died in Modarres Hospital

Abstract

BACKGROUND: Novel coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome-CoV2 as a century concern affecting public health.
 AIM: This study aimed to find the clinical and demographic characteristics of the patients died following COVID-19 development at Modarres Hospital, Tehran, Iran.
 METHODS: In this descriptive-analytical cross-sectional study, 62 patients died following COVID-19 were studied in terms of age, gender, body mass index, comorbidity, symptoms, liver profile, lipid profile, hemoglobin, platelet, white blood cell, lymphocytes, neutrophils, C-reaction protein, polymerase chain reaction (PCR), creatine phosphokinase, creatinine, blood urea nitrogen (BUN), potassium, magnesium, and sodium.
 RESULTS: The results showed that 71% of patients were male and 69.4% had positive PCR test indicating low sensitivity of the test; 90.3% of patients were above 60 years old; 56.5 of patients had lymphocytopenia; the mean age was 67.62 ± 15.07 years; with symptoms lasting 6.24 days. The mean serum creatinine and BUN were 3.18 g/dl and 125.9 mg/dl, respectively, indicating renal involvement. All patients had pulmonary involvement accompanied by other organ involvements. Regarding symptoms, 72% of patients showed fever. Some affected patients had diarrhea, lethargy, and fatigue. A comparison of comorbidities by gender showed no significant differences.
 CONCLUSION: According to our results, the majority of patients were overweight. In people who are more than 60 years, multi-organ failure was notable. Fever, cough, and shortness of breath were dominant symptoms like other studies, but neurological complications following COVID-19 as meningoencephalitis is possible that can be used as a differential diagnosis. We did not found differences between male and female regarding comorbidity, symptoms, and mortality rate.

Description of Epidemiological Features, Symptoms and Mortality of the Patients with COVID–19 in Some Provinces of Iran

“…27 In a study by Besharat et al, the results showed that 71% of patients were male and the mean age was 67.62 years with symptoms lasting 6.24 days. 28 This study was consistent with our results regarding the duration of the symptoms that may be related to the genetics (level of ACE2 receptors) of the same population. 29 Like our study, Besharat et al reported that fever, cough, and shortness of breath were dominant symptoms.…”

“…29 Like our study, Besharat et al reported that fever, cough, and shortness of breath were dominant symptoms. 28 In conclusion, according to the results, the mean time from onset of symptoms to hospitalization, isolation, and discharge were similar in women and men. ICU admission was about four times higher in men than women and the most common comorbidity in women and men was cardiovascular disease and diabetes.…”

Acute kidney injury in hospitalized COVID-19 patients in Iran; a systematic review and meta-analysis

“…The summary of characteristics extracted from studies is presented in Table 1. From 22 included studies, 9 were cohort (17,(19)(20)(21)(23)(24)(25)33,36), 8 were cross-sectional (26,(30)(31)(32)34,35,37,38), one was case-control (28), and 4 were trials (18,22,27,29). Nineteen studies had completed peer-review processes and were published from June to November 2020; while three studies (21,24,32) were not granted publication and peer-review at the time of inclusion.…”

“…In three studies, patients were specifically from intensive care unit (ICU) (19,30,31). Two studies enrolled a population of kidney transplant recipients (37,38), one only deceased patients (34), and one patients who underwent concurrent cardiac surgery (36). The funnel plot to evaluate publication bias is demonstrated in Figure 2.…”

Postmortem Liver Pathology Findings in Patients With COVID-19: A Systematic Review

“…The COVID-19 has not been previously found in humans; up to now, no specific effective antiviral therapies have been identified for it. Besides, the virus infection diagnosis is difficult and crucial in most cases [3,4].…”