Clinical and Colonoscopic Investigation of Skipped Periappendiceal Lesions in Ulcerative Colitis

Abstract

A close association is found between disease activity in the skipped periappendiceal lesion and that in the distal lesion of UC.

Diagnostic evaluation of appendiceal orifice inflammation in ulcerative colitis

“…Since then, physicians have given more attention to AOI. After 1990, several endoscopic studies reported the incidence of AOI in UC patients, which ranged from 7.9% to 27.4% of all UC patients (5,(15)(16)(17) and from 9.4% to 75% in patients with only distal UC (12,(18)(19)(20). In the present study, we noted that the AOI + rate in UC was 26.2%, and this rate did not differ between patients with proctitis, left-sided colitis, and extensive colitis.…”

Appendiceal Orifice Inflammation in an 8-Year-Old Girl with Ulcerative Colitis Complicating Wilson's Disease

“…6 Yamagishi and colleagues explored the relationship between the continuous distal lesion of UC and the skipped periappendiceal lesion by observing colonoscopic changes in both lesions and reported that activity in the distal lesion correlated well with that in the skipped periappendiceal lesion. 7 Matsumoto and co-workers used colonoscopy to study two UC groups with or without AOI. The endoscopic remission rate at 12 months was higher in the AOI-positive group than in the AOI-negative group.…”

Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

“…The influence of combined AOI in the severity of UC was studied in four articles (15)(16)(17)29) including 436 subjects (AOI positive: 123; AOI negative: 313). There was significant heterogeneity among studies for left-sided colitis and the random effects model was used for merging of the effect sizes, while no heterogeneity was found among the studies for proctitis and the fixed effect model was used.…”

“…Then, 321 completely unrelated studies and 140 reviews, letters or abstracts were excluded, and 45 articles remained. By screening of the full text, 19 studies were finally included in the present meta-analysis (5)(6)(7)(15)(16)(17)19,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). The basic information of the selected studies is listed in tables I-III.…”

“…All these studies seem to draw attention to this skip-lesion change in UC. The clinical significance of appendiceal orifice inflammation (AOI) in UC has been extensively elucidated (15)(16)(17).…”