Clinical and Biological Relationship Between Chronic Lymphocytic Thyroiditis and Papillary Thyroid Carcinoma

Antonaci, A; Consorti, Fabrizio; Mardente, Stefania; Giovannone, Gloria

doi:10.3727/096504009789735431

Cited by 39 publications

(35 citation statements)

References 77 publications

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“…In addition to the classical HT, recent studies have proposed that IgG4-related thyroiditis may be considered as a variant of HT (2). The association between HT and PTC has been a subject of long and ongoing debate (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Hashimoto's thyroiditis (HT) -chronic lymphocytic thyroiditis or autoimmune thyroiditis -is a well-defined clinicopathologic entity and its incidence has increased over the past 50 years (1). HT is characterized by hypothyroidism, the presence of serum antithyroglobulin and antiperoxidase antibodies, and widespread lymphocytic infiltration with depletion of follicular cells.…”

Section: Introductionmentioning

confidence: 99%

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The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Lee

Kim

Choi

et al. 2013

European Journal of Endocrinology

273

259

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Objective: No consensus exists on the association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT). To resolve this controversy, this study aimed to evaluate the relationship between the two conditions using a meta-analysis. Methods: We searched relevant published studies using citation databases including PubMed, Embase, and ISI Web of Science. The effect sizes of clinicopathologic parameters were calculated by odds ratio (OR), weighted mean difference, or hazard ratio (HR). The effect sizes were combined using a randomeffects model. Results: Thirty-eight eligible studies including 10 648 PTC cases were selected. Histologically proven HT was identified in 2471 (23.2%) PTCs. HT was more frequently observed in PTCs than in benign thyroid diseases and other carcinomas (ORZ2.8 and 2.4; P!0.001). PTCs with coexisting HT were significantly related to female patients (ORZ2.7; P!0.001), multifocal involvement (ORZ1.5; PZ0.010), no extrathyroidal extension (ORZ1.3; PZ0.002), and no lymph node metastasis (ORZ1.3; PZ0.041). Moreover, PTCs with HT were significantly associated with long recurrence-free survival (HRZ0.6; PZ0.001). Conclusions: Our meta-analysis showed that PTC is significantly associated with pathologically confirmed HT. PTC patients with HT have favorable clinicopathologic characteristics compared with PTCs without HT. However, patients with HT need to be carefully monitored for the development of PTC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Lee

Kim

Choi

et al. 2013

European Journal of Endocrinology

273

259

View full text Add to dashboard Cite

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“…The pathogenesis and the prognosis of the coexistence of PTC and Hashimoto's thyroiditis remain controversial. But Hashimoto's thyroiditis might represent the host immune response to preexisting PTC; PTC might be induced or triggered by preexisting Hashimoto's thyroiditis, and a common mechanism, such as imbalance between apoptotic/antiapoptotic pathways, may be involved in the two diseases [26]. Previous studies have reported that chronic inflammation responses such as those associated with autoimmune thyroiditis might act as carcinogens [27] or rearranged in transformation/PTC oncogene that is known to be highly specific to PTC might be expressed in Hashimoto's thyroiditis [28].…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors for Incidental Contralateral Carcinoma in Patients with Unilateral Micropapillary Thyroid Carcinoma

et al. 2012

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Background: Whether thyroid lobectomy alone is a sufficient treatment for papillary thyroid microcarcinoma (PTMC) remains controversial. The aim of this study is to evaluate the predictive factors for incidental contralateral carcinoma in patients confirmed of unilateral PTMC preoperatively. Methods: Between January 2007 and December 2009, 393 patients underwent thyroid surgery for unifocal and unilateral PTMC preoperatively at Pusan National University Hospital. A total thyroidectomy with central neck dissection was routinely performed for these patients during this study period. Results: Among the 393 cases in the cohort, 77 patients (19.6%) had incidental PTMC in the contralateral lobe. In patients with incidental contralateral carcinoma, there was higher prevalence in extrathyroid extension, occult ipsilateral carcinoma, pathologic Hashimoto's thyroiditis, and central lymph node metastasis compared to those without contralateral carcinoma. The mean tumor size also increased in patients with contralateral carcinoma. Multivariate logistic regression showed that extrathyroid extension (P = 0.049), occult ipsilateral carcinoma (P < 0.001), pathologic Hashimoto's thyroiditis (P = 0.038), and central lymph node metastasis (P = 0.002) were predictive factors for incidental contralateral carcinoma. Conclusion:In conclusion, multifocality in the ipsilateral lobe, central lymph node metastasis, extrathyroid extension, and Hashimoto's thyroiditis is associated with the presence of contralateral carcinoma. Thus, if these factors are found by preoperative and/or postoperative evaluation, total thyroidectomy or completion thyroidectomy is necessary for the treatment of PTMC. (Endocrinol Metab 27:194-199, 2012)

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“…On the other hand, some microscopic papillary carcinomas show a metastatic phenotype. In this setting autoimmune thyroiditis and papillary cancer have provided a useful model with which to examine interactions between cancer and the immune system (2).…”

Section: Introductionmentioning

confidence: 99%

Cross-talk between NO and HMGB1 in lymphocytic thyroiditis and papillary thyroid cancer

Mardente¹

2010

Oncol Rep

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Abstract. The controversy on whether or not inflammatory infiltrates in chronic lymphocytic thyroiditis predispose to cancer, has now merged into a debate over the role of the inflammatory infiltrates. The question is how and why some cells become transformed and what factors allow them to spread and in some cases become invasive. Here, we show that the amount of inflammatory mediators such as nitric oxide (NO) and high mobility group Box 1 protein (HMGB1) produced in thyroiditis microenvironment increases in tumors and could be involved in the cellular transformation process. NO and HMGB1 are known to attract macrophages that would promote angiogenesis, matrix remodelling and suppression of an efficient immune response. Inflammatory infiltrates could increase the risk of papillary cancer in patients with autoimmune lymphocytic thyroiditis. Cytokines and soluble inflammatory mediators involved in cancer-related inflammation are not only a target for innovative diagnostic and therapeutic strategies but they also represent a future challenge for oncologists.

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Clinical and Biological Relationship Between Chronic Lymphocytic Thyroiditis and Papillary Thyroid Carcinoma

Cited by 39 publications

References 77 publications

The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Predictive Factors for Incidental Contralateral Carcinoma in Patients with Unilateral Micropapillary Thyroid Carcinoma

Cross-talk between NO and HMGB1 in lymphocytic thyroiditis and papillary thyroid cancer

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