Clinical and Biological Overlap between Schizophrenia, Autism Spectrum Disorder, and Trauma and Stress-Related Disorders: The Three-Tree Model of SCZ-ASD-TSRD

Abstract

There is significant overlap in the clinical and neurobiological profiles of schizophrenia (SCZ), autism spectrum disorder (ASD), and trauma- and stress-related disorders (TSRDs); moreover, they often co-occur as comorbid disorders. Although current international classification criteria and those in the psychiatry/psychology field recognize such comorbidities, the assessment and treatment of these patients are provided as independent disorders. In this chapter, we summarize the current understanding of the attributes shared by the three disorders and discuss the possible contributors to the development of SCZ, ASD, and TSRD, which include environmental, genetic, and biological factors. We also propose a three-tree model that represents the clinical and biological relationships among the three diseases as a new perspective for assessing and treating these disorders. A comprehensive understanding of these disorders will enable improvements in medical care for patients with these illnesses.