Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis

Gheorghe, Gina; Ionescu, Vlad; Moldovan, Horațiu; Diaconu, Camelia Cristina

doi:10.3390/diagnostics13030369

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…Previous studies have reported con icting ndings regarding the risk of PC in AP or CP between males and females. 7,10,20,30 A recent study utilizing the UK Biobank cohort reported that males with AP had a higher risk of PC than females, while females with CP had a higher risk of PC than males. 29 However, in this study, females showed a higher risk of PC in RAP, CP with AP, and SAP groups, and similar risk in CP without AP group compared to males.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Park

Kim

Han

et al. 2023

Preprint

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We aimed to evaluate the incidence and risk of PC in pancreatitis. We identified patients with acute pancreatitis (AP) (n = 225,811, 50.0%) and chronic pancreatitis (CP) (n = 225,685, 50.0%) from Korean population-based data and matched them with age- and sex-matched controls (n = 4,514,960). We analyzed the incidence and adjusted hazard ratios (aHRs) of PC among patients followed for more than 2 years or 5 years, and assessed risk changes over time in single episode of AP (SAP), recurrent AP (RAP), CP with AP, and CP without AP groups. We also performed subgroup analysis for both sexes. The incidences (per 104 person-years) and risks (aHR) of PC were higher in the RAP (12.69, 5.00) or CP with AP (12.12, 5.74) groups compared to the SAP (2.31, 1.32) or CP without AP (2.28, 1.57) groups. The risks of PC decreased over time, however, the risk of PC remained elevated in the RAP and CP with AP groups for more than 8 years. Females with RAP, SAP, and CP with AP had higher risks of PC than males. The risk of PC is higher and persists for longer duration in patients with RAP and CP with AP compared to those with SAP or CP without AP.

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Section: Discussionmentioning

confidence: 99%

Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Park

Kim

Han

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Comparative analysis of leptin and carcinoembryonic antigen-related cell adhesion molecule 1 plasma expression in pancreatic cancer and chronic pancreatitis patients

Gheorghe,

Diaconu,

Mambet

et al. 2024

Heliyon

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Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Park,

Kim,

Han

et al. 2023

Sci Rep

View full text Add to dashboard Cite

We aimed to evaluate the incidence and risk of pancreatic cancer (PC) in pancreatitis. We identified patients with acute pancreatitis (AP) (n = 225,811, 50.0%) and chronic pancreatitis (CP) (n = 225,685, 50.0%) from Korean population-based data and matched them with age- and sex-matched controls (n = 4,514,960). We analyzed the incidence and adjusted hazard ratios (aHRs) of PC among patients followed for more than 2 years or 5 years, and assessed risk changes over time in single episode of AP (SAP), recurrent AP (RAP), CP with AP, and CP without AP groups. We also performed subgroup analysis for both sexes. The incidences (per 104 person-years) and risks (aHR) of PC were higher in the RAP (12.69, 5.00) or CP with AP (12.12, 5.74) groups compared to the SAP (2.31, 1.32) or CP without AP (2.28, 1.57) groups. The risks of PC decreased over time, however, the risk of PC remained elevated in the RAP and CP with AP groups for more than 8 years. Females with RAP, SAP, and CP with AP had higher risks of PC than males. The risk of PC is higher and persists for longer duration in patients with RAP and CP with AP compared to those with SAP or CP without AP.

show abstract

Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis

Cited by 3 publications

References 65 publications

Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Comparative analysis of leptin and carcinoembryonic antigen-related cell adhesion molecule 1 plasma expression in pancreatic cancer and chronic pancreatitis patients

Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

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