Abstract:Dear Sir, I thank Dr. Slevin and coauthors for writing an excellent account of the clinical and biologic relevance of hyaluronic acid (HA) and its fragments. In 1985, the seminal work from Dr. Kumar's group offered a glimpse of the role of HA fragments in angiogenesis. 1 In later years, the same group helped to elucidate some of the signal transduction mechanisms by which HA fragments stimulate bovine endothelial cell proliferation, migration and adhesion. 2 Consistent with the findings of Dr. Kumar's group, w… Show more
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