Clinical and Biochemical Profile of Monoclonal Gammopathies in Caribbean Patients in a Resource-limited Setting

Buchner-Daley, L M; Brady-West, Doreen; McGrowder, Donovan

doi:10.7314/apjcp.2012.13.12.6501

Cited by 5 publications

(8 citation statements)

References 19 publications

(15 reference statements)

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“…Contrary to the well-established data also confirmed by the Buchner et al study 10 in Caribbean patients in the West Indies, in our study, there was a higher incidence of MM in women than men (male-to-female ratio of 1:1.24 compared with 1.54:1 in the general population). In the United States, there is a higher incidence of obesity in the black population, with a 37.1% obesity rate in men compared with 32% in white men and 56.6% in black women compared with 32.8% in white women.…”

Section: Discussioncontrasting

confidence: 99%

“… 8 Nossent et al 9 showed that the incidence of MM in a single French West Indies medical institution was the highest among all hematologic malignancies. 9 In their study of MM at the University Hospital of West Indies, Buchner-Daley et al 10 found that most patients with MM had the most advanced stage and end-organ damage. Contrary to reported findings in the US population, Buchner-Daley et al 10 found that the profile of the Caribbean patients in their study was similar to findings in the white population in the United States.…”

Section: Introductionmentioning

confidence: 99%

“…9 In their study of MM at the University Hospital of West Indies, Buchner-Daley et al 10 found that most patients with MM had the most advanced stage and end-organ damage. Contrary to reported findings in the US population, Buchner-Daley et al 10 found that the profile of the Caribbean patients in their study was similar to findings in the white population in the United States. It remains unclear if the clinical characteristics of MM are different in Afro-Caribbean patients who reside in the West Indies compared with the Afro-Caribbean population in the United States.…”

Section: Introductionmentioning

confidence: 99%

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Findings of Multiple Myeloma in Afro-Caribbean Patients in the United States

Banavali

Neculiseanu

Draksharam³

et al. 2018

JGO

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BackgroundMultiple myeloma (MM) is the second most common malignancy in the United States and has a higher incidence in the black and Afro-Caribbean population. There remain limited data on disease presentation and clinical characteristics in this patient group in the United States. The clinical profile of MM in this underrepresented patient group is described here.MethodsThis retrospective study was conducted at Kings County Hospital, an urban New York City hospital in a majority Afro-Caribbean neighborhood. Data from patients diagnosed with MM from 2000 through 2013 were collected from the institution’s tumor registry. Clinical and demographic characteristics of these patients were then analyzed.ResultsPatients with a diagnosis of MM were identified (N = 287). Data were available for 231 patients and of these, 97% self-identified as black. 55% were female, and there was a male-to-female ratio of 1:1.2. The mean age of female patients was 64 years; that of male patients was 63 years. Of the 231 patients, 81% had anemia, 68% had bone lesions, 47% had renal impairment, and 29% had hypercalcemia. Low levels of monoclonal protein were present in 27% of patients and 57% had disease of International Staging System stages I and II. Women had higher BMI than men.ConclusionThe mean age of presentation of MM in Afro-Caribbean patients is similar to that in the standard population; however, unlike the general US population, there was a higher incidence in women; mean BMI of women also was higher than that of male patients. A sizeable percentage of Afro-Caribbean patients with MM presented with low levels of monoclonal protein in the presence of multiorgan involvement and damage, suggesting the need for early and aggressive diagnostic testing.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Findings of Multiple Myeloma in Afro-Caribbean Patients in the United States

Banavali

Neculiseanu

Draksharam³

et al. 2018

JGO

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“…They provide precise amount of the involved and uninvolved immunoglobulin of affected isotype of the patients [20]. A large amount of myelomas make complete heavy chain immunoglobulin molecules of about IgG (55%), IgA(22%) [24], Bi-clonal (2%), light chain (16%), Bi-clonal (2%), and IgM (0.5%), while IgD and IgE are uncommon [25]. The amount of paraprotein made is frequently proportional to the mass of the tumor.…”

Section: Resultsmentioning

confidence: 99%

Serm Immuno Fixation Electrophoresis as a Diagnostic Method for Monoclonal Gammopathies in Patients with Multiple Myeloma

Yousif¹,

Ablhad²,

Ismail³

2019

MJS

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B cells clonal expansion (producing abnormal amounts of immunoglobulins) reflect conditions causes a group of disorders called monoclonal gammopathies. They may be appearing as a range of diseases that consist of multiple myelomas (MM). The aim of this research is to use quantify and identify monoclonal gammopathy by serum immunofixation electrophoresis (SIFE) beside the serum protein electrophoresis (SPEP) assay as a tumor marker in the diagnosis of suspected multiple myeloma cases. Serum samples were collected from 94 patients with MM, and 30 persons as control, SPEP and SIFE were used for both groups. M band determined and evaluated of M protein by the Hellabio instruments. The results of this study showed significant elevation (p

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“…The prevalence of MAH is around 3%~30% of all cancer patients (Grill et al, 2000;Stewart et al, 2005;Buchner-Daley et al, 2012;Hassan et al, 2012;Sookprasert et al, 2012). However, the incidence of MAH in China is far below the number (Xie et al, 2006;Shi et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Analysis on Survival and Prognostic Factors for Cancer Patients with Malignancy-associated Hypercalcemia

Zhang

Hu²,

Cao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: To explore the incidence, clinical characteristics, diagnosis and treatment strategies, prognosis of patients with malignancy-associated hypercalcemia (MAH). Methods: The data of 115 patients with MAH who were treated at the Medical Oncology Department of Chinese PLA General Hospital from Jan., 2001 to Dec., 2010 was retrospectively reviewed. Survival analysis was performed using the Kaplan-Meier method and the Cox proportional hazard model with statistic software SPSS 18.0. Results: The patients had blood calcium levels ranging from 2.77 to 4.87 mmol/L. Except for 9 cases who died or were discharged within 5 days after admission, all other patients recovered to normal blood calcium level after treatment with bisphosphonates or intravenous hydration and diuretics; their survival after occurrence of MAH was from 1 day to 4,051 days, and the median survival time was only 50 days. In the log-rank test, the male, renal metastasis, central nervous system symptoms and hypercalcemia occurring over 140 days after cancer diagnosis were predictors of poor survival (P=0.002, P=0.046, P=0.000, P=0.009). In the COX analysis, being male, central nervous system symptoms and hypercalcemia lasting over 140 days after cancer diagnosis were independent prognostic factors for survival time (RR=2.131, P=0.027; RR=3.054, P=0.002; RR=2.403, P=0.001). According to these factors, a score system was established to predict the patient prognosis and adjust the treatment. Conclusion: Cancer patients with MAH have an extremely poor median survival. Some independent factors indicate poor prognosis, including male gender, central nervous system symptoms and hypercalcemia lasting over 140 days after cancer diagnosis. The prognostic score can serve as a reference for MAH prognosis and treatment, worthy of further investigation.

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Clinical and Biochemical Profile of Monoclonal Gammopathies in Caribbean Patients in a Resource-limited Setting

Cited by 5 publications

References 19 publications

Findings of Multiple Myeloma in Afro-Caribbean Patients in the United States

Findings of Multiple Myeloma in Afro-Caribbean Patients in the United States

Serm Immuno Fixation Electrophoresis as a Diagnostic Method for Monoclonal Gammopathies in Patients with Multiple Myeloma

Analysis on Survival and Prognostic Factors for Cancer Patients with Malignancy-associated Hypercalcemia

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