Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

Chae, Suchan; Kim, Jin Ju; Choi, Young Min; Hwang, Kyu Ri; Jee, Byung Chul; Ku, Seung Yup; Suh, Chang Suk; Kim, Seok Hyun; Kim, Jung Gu; Moon, Shin Yong

doi:10.1093/humrep/den239

Cited by 105 publications

(107 citation statements)

References 27 publications

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“…Clinical HA was defined by a modified Ferriman and Gallwey score of more than 8 [16], and biochemical HA was defined as an elevation of serum testosterone levels above 97.5 percentile limits, which is >0.6 ng/ mL (2.1 nmol/L) for total testosterone and 2.07 ng/mL (7.2 nmol/L) for free testosterone level. When the subjects with PCOS were divided into four subgroups, the proportions in the individual groups are as follows [17]: 1) the IM/HA/PCO group (n=43, 491%), 2) the IM/PCO group (n=34, 39.6%), 3) the IM/HA group (n=9, 9.8%), and 4) the HA/PCS group (n=1, 1.5%). Control subjects were women with regular menstrual cycles (25-35 days) and had no evidence of hirsutism, acne, alopecia or endocrine dysfunction, and no polycystic ovary (< 12 follicles with size of 2-9 mm/ovary).…”

Section: Subjects and Study Designmentioning

confidence: 99%

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

et al. 2012

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POLYCYSTIC OVARY SYNDROME (PCOS) is one of the most common endocrinological problems in women. In addition to chronic oligo-anovulation, the main features of the PCOS include elevated levels of circulating androgens and/or clinical hyperandrogenism, polycystic ovary morphology, altered gonadotropin secretion, insulin resistance and/or compensatory hyperinsulinemia often associated with obesity [1]. Women affected by PCOS also show a higher risk of type 2 diabetes, dyslipidemia, hypertension and cardiovascular diseases [2][3][4].Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome Abstract. The aim of the present study was to compare the associations of anti-Müllerian hormone (AMH) with clinical or biochemical characteristics between women with and without polycystic ovary syndrome (PCOS). We also explored the optimal cutoff point of AMH to diagnose PCOS. A cross-sectional study was performed in 87 women diagnosed with PCOS and 53 healthy control subjects. Body mass index (BMI), indices of insulin resistance, metabolic syndrome-related variables, reproductive hormones and serum AMH were measured in all subjects. We conducted receiver operating characteristic (ROC) curve analysis to determine the cutoff of AMH for diagnosis of PCOS. Serum AMH levels were significantly (p <0.001) higher in women with PCOS after adjustment for age and BMI. AMH levels were not significantly related with obesity, indices of insulin resistance, and metabolic syndrome-related variables in both PCOS and control groups. In the control group, AMH levels showed positive correlations with total testosterone (p <0.001), free testosterone (p=0.024), and adiponectin (p=0.002), and showed negative correlations with age (p=0.010) and estradiol (E2) (p=0.012). However, only total (p=0.044) and free testosterone (p=0.012) levels showed significant positive correlations with serum AMH level in PCOS group. ROC curve analysis showed a cutoff point for AMH of 7.82 ng/mL (sensitivity 75.9%, specificity 86.8%) for diagnosis of PCOS. Differences of the association of AMH with clinical or biochemical characteristics between women with PCOS and control groups were observed. This might contribute to the pathogenesis of PCOS, although further investigation is necessary to elucidate the detailed mechanism.

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Section: Subjects and Study Designmentioning

confidence: 99%

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

et al. 2012

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show abstract

“…Clinical HA was defined by a modified Ferriman and Gallwey score of more than eight (20), and biochemical HA was defined as an elevation of serum testosterone levels above 97.5 percentile limits, which is O0.6 ng/ml for total testosterone level and 2.07 ng/ml for free testosterone level. When the subjects with PCOS were divided into four subgroups, the proportions in the individual groups are as follows (15): i) the IM/HA/PCO group (nZ43, 491%), ii) the IM/PCO group (nZ34, 39.6%), iii) the IM/HA group (nZ9, 9.8%), and iv) the HA/PCS group nZ1, 1.5%). Also, the presence of other endocrinopathies that could have potentially caused these phenotypes was ruled out.…”

Section: Study Populationmentioning

confidence: 99%

“…However, Asian women with PCOS are less likely to have metabolic dysfunction, IR, and obesity compared with Caucasian women with PCOS (15)(16)(17). There is little data on omentin levels within the context of PCOS (18,19).…”

Section: Introductionmentioning

confidence: 99%

Plasma omentin-1 levels are reduced in non-obese women with normal glucose tolerance and polycystic ovary syndrome

Choi¹,

Rhee²,

Kim³

et al. 2011

European Journal of Endocrinology

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Objective: Omentin-1 is a novel adipokine that increases insulin sensitivity and is expressed in visceral adipose tissue. The aim of this study was to determine the metabolic parameters that influence plasma omentin-1 levels in women with polycystic ovary syndrome (PCOS). Design and methods: A cross-sectional study was performed in 87 women with PCOS and 53 body mass index (BMI)-matched healthy controls including 39 non-obese, normal-weight (NW) PCOS women with normal glucose tolerance (NGT) and 44 BMI-and homeostasis model assessment (HOMA)-matched controls. Indices of insulin sensitivity, metabolic variables, circulating androgen levels, serum adiponectin, and omentin-1 levels were measured. A 75 g oral glucose tolerance test was performed in all participants. Results: Plasma omentin-1 levels were significantly lower in women with PCOS compared with those in BMI-matched controls (P!0.001). A significantly lower level of plasma omentin-1 was observed in non-obese women with PCOS and NGT compared with that in BMI-and HOMA-matched controls (P!0.001). Omentin-1 level was negatively correlated with BMI, indices of insulin sensitivity, and circulating androgens and was associated with greater 2 h postprandial glucose, C-peptide, and insulin levels compared with fasting values. Within the NW and NGT groups, omentin-1 levels remained negatively correlated with BMI, 2 h postprandial C-peptide, and circulating androgens and demonstrated a negative linear trend according to quartile of free testosterone (PZ0.028). Conclusions: Plasma levels of omentin-1 were reduced in non-obese women with PCOS and NGT. Postprandial hyperinsulinemia and hyperglycemia contributed more to lower omentin-1 levels than did fasting values in the setting of PCOS. Increased androgen levels contributed to decreased omentin-1 levels in women with PCOS.

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“…Clinical hyperandrogenism was defined by a modified Ferriman and Gallwey score (mF-G score) of more than 8 [22]. Biochemical hyperandrogenism was defined as an elevation of serum androgen levels beyond the 95 % confidence limits measured in 89 ovulatory, nonhirsute controls in our population who did not show polycystic ovary on ultrasonography (total testosterone >0.68 ng/mL, free testosterone >1.72 pg/mL, free androgen index >5.36) [23]. The control group consisted of 69 healthy Korean women who visited the same clinics for regular or premarriage medical evaluations with a regular menstrual cycle range of 21-35 days, normal ovaries on USG, and no hirsutism.…”

Section: Subjectsmentioning

confidence: 99%

Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women

Roh

Yoon

Song

et al. 2016

J Assist Reprod Genet

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Purpose Although many hypotheses regarding the pathogenesis of polycystic ovary syndrome (PCOS) have been generated, genetic studies have not identified specific genes that play a role in PCOS etiopathogenesis. This study aimed to investigate the relationship between TGF-β1 gene polymorphism and PCOS in Koreans. Method A total of 51 Korean women with PCOS and 69 healthy women were enrolled. We analyzed 4 single nucleotide polymorphisms (SNPs) of the TGF-β1 gene (rs11466313, rs1800469, rs2317130, and rs4803457). We also analyzed laboratory measurements, such as free testosterone, glucose, and cholesterol. Results The frequencies of rs1800469T allele negativity, rs4803457T allele negativity, the rs1800469CC genotype, and the rs4803457CC genotype showed positive associations with PCOS (P = 0.003, P = 0.027, P = 0.009, and P=0.031, respectively), whereas the haplotypes rs1800469C-rs4803457T and rs1800469T-rs4803457T showed negative associations with PCOS. A strong protective effect of the Brs1800469CT-rs4803457TT^combination (OR = 0.09) and a strong risk effect of Brs1800469CC-rs4803457CC^(OR = 6.23) for PCOS were observed. The rs1800469C/T and rs2317130C/T SNPs exhibited associations with several laboratory measurements with various levels of significance. Conclusion The results demonstrated an association of TGF-β1 gene polymorphisms with the development and/or characteristics of PCOS in the Korean population.

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Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

Cited by 105 publications

References 27 publications

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

Plasma omentin-1 levels are reduced in non-obese women with normal glucose tolerance and polycystic ovary syndrome

Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women

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