Clinical and Biochemical Changes During Exchange Transfusion

Farquhar, James W.; Smith, Hylton

doi:10.1136/adc.33.168.142

Cited by 56 publications

(27 citation statements)

References 36 publications

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“…The mean mid-exchange (4.98+1.08 mEq/I) and post-exchange (4.74+0.78 mEq/I) levels were also not significantly different from the mean pre-exchange level (4.97+1.27 Eq/I). These results are in contrast with some earlier reports that infusion of stored blood elevates serum potassium concentration and that the hyperkalaemia gets further augmented due to decreased renal potassium excretion in infants and to subsequent development of acidosis (14,15,16). Biochemistry, 1997.…”

Section: Resultscontrasting

confidence: 76%

Biochemical changes during exchange transfusion in hyperbilirubinemia in term newborn babies

Jain

Puri

Faridi

1997

Indian J Clin Biochem

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Double volume (170 ml/kg body weight) exchange transfusion was done in 52 term infants in the first week of life for neonatal hyperbilirubinemia. The M:F ratio was 1.08:1 and 37 (71.1%) babies were of low birth weight. Causes of jaundice were hemolytic in 46.2% and non-hemolytic in 41.3% cases; in 13.5% babies no cause of jaundice could be found. After exchange transfusion a fall of 14.6% and 47.4% was observed in the hemoglobin and serum bilirubin levels respectively. There was significant (p=0.0414) rise in the mean mid exchange and post-exchange serum sodium levels as compared to pre-exchange values and it was found to be due to higher donor's serum sodium levels (p=0.007). There was no effect on the serum potassium levels during or after ET.In general serum calcium levels significantly increased at mid-exchange period (p=0.0029) but post-exchange levels were same as pre-exchange. Donor's serum calcium level had no effect on the infant's serum calcium level (p=0.993). There was no change in the serum phosphate and blood urea levels during and after exchange-transfusion. The plasma glucose was significantly raised during and after ET and plasma glucose of the donors had significant effect on the infant's plasma glucose levels (p=0.043). Similarly plasma osmolality also showed significant increase during and after ET which was due to the effect of donor's plasma osmolality (p=0.007).

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Section: Resultscontrasting

confidence: 76%

Biochemical changes during exchange transfusion in hyperbilirubinemia in term newborn babies

Jain

Puri

Faridi

1997

Indian J Clin Biochem

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“…T h e use o f h ep arin ized in stead of c itra te d blood or th e a d m in is tra tio n o f b ic a rb o n a te m a y p ro b a b ly be considered m a in ly in p re m a tu re in fa n ts e x h ib itin g preex istin g severe m etabolic acidosis or a d ecreased a b ility to m etabolize c itra te [3], i.e. to gen erate b ic a rb o n a te c o u n te r-a ctin g th e acid o tic effect of th e tran sfu sio n .…”

Section: R Esults a Nd Discussionmentioning

confidence: 99%

“…W ith th e reco g n itio n a n d elim in atio n o f th e causes leading to accid en ts -such as h y p o calcaem ia, h y p erp o tassaem ia, low te m p e ra tu re of th e d o n o r blood, in a p p ro p ria te ra te o f tran sfu sio n , etc. -th e use of ex change tra n sfu sio n h a s becom e a n alm o st harm less p ro ced u re [3,5,8,11,12], M ore re c e n t pap ers call a tte n tio n to th e low p H of sto red blood [2,4,7,9] an d suggest th e use o f heparinized in ste a d of c itra te d b lood [9], or th e a d m in istra tio n o f a sufficient a m o u n t o f sodium b ic a rb o n a te d u rin g tran sfu sio n [2, 2 a] in o rd er to p re v e n t acidosis. In th is s tu d y we p re se n t some d a ta h av in g a bearin g on th is problem .…”

mentioning

confidence: 99%

Alterations in Blood pH and Acid-Base Parameters during Exchange Transfusion in the Newborn

Varga¹,

Hutás²

1966

Neonatology

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“…[1][2][3][4] One such hazard reported by several authors 2,5-10 is that of acidosis, occurring when the transfused blood contains ACD as anticoagulant. Since these studies were carried out usually between the first and third days of life, mainly on babies suffering from Rh or ABO incompatibility, we directed our interest to the acid-base balance during exchange transfusion performed after the third day of life in Greek babies whose jaundice was due to G-6-PD deficiency, or to &dquo;unknown factors.&dquo; In Greece, severe neonatal jaundice is due to G-6-PD deficiency in 34 per cent of the cases, ABO isoimmunization in 23 per cent, Rh isoimmunization in 8 per cent, napthalene exposure in 4 per cent, miscellaneous in 5 per cent, and &dquo;unknown factors&dquo; in 26 per cent.&dquo;…”

mentioning

confidence: 96%