Clinical and bacteriological analyses of bacteremia due to Corynebacterium striatum

Ishiwada, Naruhiko; Watanabe, Masaharu; Murata, Shota; Takeuchi, Noriko; Taniguchi, Toshibumi; Igari, Hidetoshi

doi:10.1016/j.jiac.2016.08.009

Cited by 28 publications

(24 citation statements)

References 28 publications

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“…2 Includes three episodes of possible IE. 3 Unknown focus or no infection. 4 Not determined due to too few observations in some cells.…”

Section: Ie Caused By Corynebacteriummentioning

confidence: 99%

“…When Corynebacterium is isolated from blood cultures, the finding is often dismissed as a contamination from normal skin flora rather than recognized as a pathogen causing true infection. Studies investigating different cohorts have indicated that between 44 and 71% of patients with Corynebacterium bacteremia have true infection [2][3][4]. Some studies have only used a bacteriological criterion (≥ 2 positive blood cultures) [2,3] whereas other studies also considered clinical features and acknowledge that intravascular devices are risk factors for true Corynebacterium infection [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The lack of a uniform definition of contamination and infection hampers the possibility to draw conclusions about the incidence of true Corynebacterium infections. Moreover, available studies describe limited number of cases and have a retrospective design [2][3][4][5]7].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have investigated the features of infections with specific Corynebacterium species. Of non-diphtheriae corynebacteria, Corynebacterium striatum and Corynebacterium jeikeium have often been reported as pathogens [3,5,7,9,12]. However, at present, there is insufficient data on how species determination of corynebacteria can help to determine the risk for true infection or even IE in patients with Corynebacterium bacteremia.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

From contamination to infective endocarditis—a population-based retrospective study of Corynebacterium isolated from blood cultures

Rasmussen

Mohlin

Nilson

2019

Eur J Clin Microbiol Infect Dis

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Corynebacterium is a genus that can contaminate blood cultures and also cause severe infections like infective endocarditis (IE). Our purpose was to investigate microbiological and clinical features associated with contamination and true infection. A retrospective population-based study of Corynebacterium bacteremia 2012-2017 in southern Sweden was performed. Corynebacterium isolates were species determined using a matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS). Patient were, from the medical records, classified as having true infection or contamination caused by Corynebacterium through a scheme considering both bacteriological and clinical features and the groups were compared. Three hundred thirty-nine episodes of bacteremia with Corynebacterium were identified in 335 patients of which 30 (8.8%) episodes were classified as true infection. Thirteen patients with true bacteremia had only one positive blood culture. Infections were typically community acquired and affected mostly older males with comorbidities. The focus of infection was most often unknown, and in-hospital mortality was around 10% in both the groups with true infection and contamination. Corynebacterium jeikeium and Corynebacterium striatum were significantly overrepresented in the group with true infection, whereas Corynebacterium afermentans was significantly more common in the contamination group. Eight episodes of IE were identified, all of which in patients with heart valve prosthesis. Six of the IE cases affected the aortic valve and six of seven patients were male. The species of Corynebacterium in blood cultures can help to determine if a finding represent true infection or contamination. The finding of a single blood culture with Corynebacterium does not exclude true infection such as IE.

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“…2 Includes three episodes of possible IE. 3 Unknown focus or no infection. 4 Not determined due to too few observations in some cells.…”

Section: Ie Caused By Corynebacteriummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

From contamination to infective endocarditis—a population-based retrospective study of Corynebacterium isolated from blood cultures

Rasmussen

Mohlin

Nilson

2019

Eur J Clin Microbiol Infect Dis

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“…Yapılan çalışmalarda C.striatum suşlarının en sık yoğun bakım ünitelerinden izole edildiği bildirilmiştir (4,10,13) . Bu çalışmada da, suşların % 71'i yoğun bakım ünitelerinden elde edilmiştir.…”

Section: Gereç Ve Yöntemunclassified

In-vitro antibiotic resistance profile of Corynebacterium striatum strains isolated from clinical samples

Aşgın¹

2019

Ankem Derg

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Corynebacterium striatum is a normal inhabitant of human skin and mucous membranes. However, it has recently been reported as the cause of invasive infections and outbreaks. In addition, multidrug resistance of the bacterium is a significant concern. In this study, we aimed to determine the antimicrobial resistance of C.striatum strains to contribute to empirical antibiotic usage protocols. A total of 235 C.striatum strains isolated from inpatients between January 2017-December 2018 were investigated retrospectively. The strains were identified using the Phoenix 100 (Becton Dickinson, MD, USA) fully automated system and antibiotic susceptibilities of isolates was determined by using Kirby-Bauer disc diffusion method. Antimicrobial susceptibilities of strains were interpreted according to The European Committee on Antimicrobial Susceptibility Testing standards. Of the 235 patients in whom strains were isolated, 114 were female and 121 were male. The mean age was 72 years and 70 % (n=165) of the patients were in the geriatric age group (65 years, and older). C.striatum strains were isolated from intensive care units at a rate of 71 %. The strains were mostly isolated from the surgical intensive care unit (27 %) internal intensive care unit (26 %) and palliative care unit (14 %). C.striatum strains obtained from the respiratory tract samples (41 %), blood (32 %), and wound samples (27 %). All strains were susceptible to vancomycin and linezolid. However, the resistance rate to gentamicin was 37 % and for erythromycin, it was 55 %. The resistance rates to clindamycin, tetracycline, ciprofloxacin, and cefotaxime were extremely high at 87 %, 93 %, 94 %, and 96 %, respectively. According to our study results, treatment options for C.striatum infections are limited. Therefore vancomycin or linezolid can be preferred in empirical antibiotic treatment.

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Worldwide survey of Corynebacterium striatum increasingly associated with human invasive infections, nosocomial outbreak, and antimicrobial multidrug-resistance, 1976–2020

et al. 2021

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Corynebacterium striatum is part of microbiota of skin and nasal mucosa of humans and has been increasingly reported as the etiologic agent of community-acquired and nosocomial diseases. Antimicrobial multidrug-resistant (MDR) C. striatum strains have been increasingly related to various nosocomial diseases and/or outbreaks worldwide, including fatal invasive infections in immunosuppressed and immunocompetent patients. Although cases of infections by C. striatum still neglected in some countries, the improvement of microbiological techniques and studies led to the increase of survival of patients with C. striatum nosocomial infections at different levels of magnitude. Biofilm formation on abiotic surfaces contributes for the persistence of virulent C. striatum and dissemination of antimicrobial resistance in hospital environment. Besides that, empirical antibiotic therapy can select multi-resistant strains and transfer intra and interspecies genes horizontally. In this study, a worldwide survey of C. striatum human infections and nosocomial outbreaks was accomplished by the analysis of clinical–epidemiological and microbiological features of reported cases from varied countries, during a 44-year period (1976–2020).

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Clinical and bacteriological analyses of bacteremia due to Corynebacterium striatum

Cited by 28 publications

References 28 publications

From contamination to infective endocarditis—a population-based retrospective study of Corynebacterium isolated from blood cultures

From contamination to infective endocarditis—a population-based retrospective study of Corynebacterium isolated from blood cultures

In-vitro antibiotic resistance profile of Corynebacterium striatum strains isolated from clinical samples

Worldwide survey of Corynebacterium striatum increasingly associated with human invasive infections, nosocomial outbreak, and antimicrobial multidrug-resistance, 1976–2020

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