Clinical and antimicrobial profile of Coagulase Negative staphylococci in a tertiary care hospital

Chavan, Sonal P.; Sv, Jalgaonkar; Raut, Sharmila; Khadse, Ravindra

doi:10.18203/2320-6012.ijrms20173533

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…9 However , vancomycin sensitivity is 100% in this study. MRSA is (52%) compared to INSAR study 1 (37.2%) and MRCoNS (55%) compared to MRCoNS (33%) in Karnataka study 10 and (63.2%) in Maharashtra study 11 leading to penicillin and cephalosporins antibiotics failure except for antistaphylococcal activity.…”

Section: Discussionmentioning

confidence: 96%

Speciation andAntibiogram ofStaphylococcal Isolates fromaTertiary Care Hospital ofNorth East India

gmawii

uii

Laldinmawii³

et al. 2018

ijmsci

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Background: Infections by staphylococci has been one of the most common isolates among the gram positive cocci. However emergence of methicillin resistant strains have led to failure of many antibiotics. The present study was undertaken to find out the species of staphylococcal isolates prevalent in Civil Hospital Aizawl, and to correlate its antibiotic sensitivity pattern due to the fact that they are the leading cause of infections and bacteremia. Methods: Specimens collected between January 2017 to December 2017 were processed using standard conventional methods. Staphylococcal isolates were speciated and antibiogram done using automated culture methods. Interpretation were done as per CLSI guidelines. Results: 220 non repeated clinical isolates were identified as Staphylococcus species of which 45.4% were S aureus and 54.6%were CoNS. Out of 120 CoNS, 36.6% were S haemolyticus, 26.7% were S epidermidis, 12.5% were S saprophyticus, 12.5% were S hominis, 3.3% were S xylosus,3.3% were S cohinii, 1.7% were S lentus, 1.7% were S warneri, 1.7% were S lugdunensis, and 9.2% were unidentified CoNS. Among the S aureus , 52% were MRSA and among CoNS , 55% were MRCoNS. All of the isolates were sensitive to Vancomycin.

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Section: Discussionmentioning

confidence: 96%

Speciation andAntibiogram ofStaphylococcal Isolates fromaTertiary Care Hospital ofNorth East India

gmawii

uii

Laldinmawii³

et al. 2018

ijmsci

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Clinical Analysis ofStaphylococcusKeratitis According to Coagulase Positivity

Choi

Cho

Lee

2019

J Korean Ophthalmol Soc

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Purpose:To analyze clinical aspects in a cohort of patients with Staphylococcus keratitis according to coagulase positivity (coagulase negative Staphylococcus [CNS], coagulase positive Staphylococcus [CPS]). Methods: Epidemiology, predisposing factors, clinical characteristics, treatment outcomes, and antibiotic susceptibility were comparatively analyzed in 138 cases of culture-proven Staphylococcus keratitis (94 eyes with CNS and 44 eyes with CPS) over 20 years (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017) at Yeungnam University Hospital. Poor clinical outcomes were defined as a final corrected visual acuity <0.1, a decreased visual acuity after treatment, complications, or surgical treatment. Risk factors for poor clinical outcomes were evaluated in the total cohort and analyzed using multivariate logistic regression. Results: The most common predisposing factors were corneal trauma in the CNS group (47.9%) and previous ocular surface disease in the CPS group (31.8%). No significant differences were observed in mean age, sex, previous ocular surface disease, epithelial defect size, and hypopyon between the two groups. Methicillin susceptibility (39.4% vs. 72.7%, p < 0.001) was significantly lower in the CNS group, and poor clinical outcomes (28.0% vs. 43.9%, p = 0.076) were more common in the CPS group. The significant risk factors for poor clinical outcomes were initial best-corrected visual acuity <0.1, epithelial defect size ≥ 5 mm 2 , symptom duration ≥10 days, and hypopyon. Conclusions: No significant differences were observed in epidemiological factors and initial clinical characteristics between the two study groups, but predisposing factors and methicillin susceptibility differed between the two groups. Treatment outcomes were relatively worse in the CPS group than in the CNS group, but the difference was not statistically significant. Poor clinical outcomes were more associated with long symptom duration and poor initial clinical characteristics than with coagulase positivity.

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Clinical and antimicrobial profile of Coagulase Negative staphylococci in a tertiary care hospital

Cited by 2 publications

References 15 publications

Speciation andAntibiogram ofStaphylococcal Isolates fromaTertiary Care Hospital ofNorth East India

Speciation andAntibiogram ofStaphylococcal Isolates fromaTertiary Care Hospital ofNorth East India

Clinical Analysis ofStaphylococcusKeratitis According to Coagulase Positivity

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