Clinical and Antibiofilm Efficacy of Antimicrobial Hydrogels

Finnegan, Simon; Percival, Steven L.

doi:10.1089/wound.2014.0556

Cited by 44 publications

(29 citation statements)

References 35 publications

(41 reference statements)

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“…Antimicrobial hydrogels, e.g. Flaminal Hydro and Forte, incorporate two enzymes, lactoperoxidase and glucose oxidase, and inhibit bacterial growth (Beele et al, 2012;White, 2014;Finnegan and Percival, 2014). Oxyzyme and Iodozyme are examples of two-layer hydrogel dressings which release both oxygen and iodine onto the wound surface…”

Section: Forms and Productsmentioning

confidence: 99%

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

2020

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Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician knowledge of dressing properties in wound care. Optimal wound management depends on accurate patient assessment, wound diagnosis, clinicians' knowledge of the wound healing process and properties of wound dressings. We conducted a comprehensive review of the physical properties of wound dressing products, including the advantages and disadvantages, indications and contraindications and effectiveness of first-line interactive/bioactive dressing groups commonly used in clinical practice. These include semipermeable films, foams, hydroactives, alginates, hydrofibers, hydrocolloids, and hydrogels. In making decisions regarding dressing product selection, clinicians need to ensure a holistic assessment of patient and wound etiology, and understand dressing properties when making clinical decisions using wound management guidelines to ensure optimal patient outcomes. This review has highlighted there is lack of high quality evidence and the need for future well designed trials.

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Section: Forms and Productsmentioning

confidence: 99%

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

2020

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“…In current standard of care, the former is typically provided by systemic or local antimicrobials (antibiotics and antiseptics) and the latter by wound dressings and bandages. Incorporation of antimicrobial agents, such as silver, into hydrogels or other dressings delivers both functions in a single composition . Here, we report that both direct antimicrobial activities and microbial barrier properties can be designed into a single multifunctional biopolymer.…”

Section: Introductionmentioning

confidence: 98%

“…Incorporation of antimicrobial agents, such as silver, into hydrogels or other dressings delivers both functions in a single composition. [25,26] Here, we report that both direct antimicrobial activities and microbial barrier properties can be designed into a single multifunctional biopolymer.…”

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confidence: 99%

Amino Acid Block Copolymers with Broad Antimicrobial Activity and Barrier Properties

Bevilacqua

Huang

Wall

et al. 2017

Macromolecular Bioscience

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Antimicrobial properties of a long‐chain, synthetic, cationic, and hydrophobic amino acid block copolymer are reported. In 5 and 60 min time‐kill assays, solutions of K100L40 block copolymers (poly(l‐lysine·hydrochloride)100‐b‐poly(l‐leucine)40) at concentrations of 10–100 µg mL−1 show multi‐log reductions in colony forming units of Gram‐positive and Gram‐negative bacteria, as well as yeast, including multidrug‐resistant strains. Driven by association of hydrophobic segments, K100L40 copolymers form viscous solutions and self‐supporting hydrogels in water at concentrations of 1 and 2 wt%, respectively. These K100L40 preparations provide an effective barrier to microbial contamination of wounds, as measured by multi‐log decreases of tissue‐associated bacteria with deliberate inoculation of porcine skin explants, porcine open wounds, and rodent closed wounds with foreign body. Based on these findings, amino acid copolymers with the features of K100L40 can combine potent, direct antimicrobial activity and barrier properties in one biopolymer for a new approach to prevention of wound infections.

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“…The hydration related properties of wound dressings, that is, water uptake and its retention as well as polymer swelling, influence their potential in maintaining a moist environment over wound area and avoiding fluid accumulation . The fluid handling capacity of WDs depends on the physicochemical properties of polymer, interaction between water and polymer and the design of the dressing . The understanding of solvent transport, relaxation processes, and their kinetics during hydration of polymeric matrices is important to design effective pharmaceutical formulations .…”

Section: Introductionmentioning

confidence: 99%

“…8 The fluid handling capacity of WDs depends on the physicochemical properties of polymer, interaction between water and polymer and the design of the dressing. [9][10][11][12][13][14] The understanding of solvent transport, relaxation processes, and their kinetics during hydration of polymeric matrices is important to design effective pharmaceutical formulations. 15,16 It should also be true for WD membranes.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal characterization of hydration process of asymmetric polymeric wound dressings for decubitus ulcers

et al. 2017

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Pressure ulcers belong to the most chalenging clinical problems. As hydration level of such wounds is important for optimal healing, preparation of new wound dressing (WD) materials for pressure ulcers requires thorough in vitro evaluation as prerequisite to final in vivo testing. The aims of the study were to: (a) develop a simple method of preparation of asymmetric polymeric membrane, (b) to propose a set of in vitro methods for membrane characterization during hydration. A polyvinyl alcohol asymmetric membrane with homogeneous skin layer and porous spongy layer was developed with nonadhesive properties and ability to absorb and retain the water. Complementary methods, including magnetic resonance imaging, allowed quantitative assessment of spatiotemporal aspects of membrane hydration, that is, global water uptake; swelling; local hydration in terms of proton density mapping; spatial distribution of T relaxation time; Young's modulus; piercing resistance. The proposed method of initial wound dressing evaluation seems to be promising to compare various WD formulations, to assess the time required to prepare WD membrane to be applied to the wound and to assess how long WD retains desired working properties. The developed asymmetric membrane seems to be a good candidate for further evaluation. It was found that: Young's modulus of hydrated membrane was comparable to those of human skin; asymmetrical structure was retained during the entire hydration period; each layer had its own distinct, hydration related, properties and their spatiotemporal evolution; relatively slow changes of membrane properties during the potential WD application time-span of several hours was observed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 843-853, 2018.

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Clinical and Antibiofilm Efficacy of Antimicrobial Hydrogels

Cited by 44 publications

References 35 publications

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

Amino Acid Block Copolymers with Broad Antimicrobial Activity and Barrier Properties

Spatiotemporal characterization of hydration process of asymmetric polymeric wound dressings for decubitus ulcers

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