Clinical and antibacterial effect of an anti-inflammatory toothpaste formulation with Scutellaria baicalensis extract on experimental gingivitis

Arweiler, Nicole Birgit; Pergola, Gregory; Kuenz, Jana; Hellwig, Elmar; Sculean, Anton; Auschill, Thorsten Mathias

doi:10.1007/s00784-010-0471-1

Cited by 36 publications

(16 citation statements)

References 25 publications

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“…The PubMed-MEDLINE, Cochrane CENTRAL, IndMed, and other sources identified 1378 unique records which were screened by title and abstract [ Figure 2 ]. After full-text reading, 10 records[ 15 16 17 27 28 29 30 31 32 33 ] were excluded. This exclusion resulted in 19 full-text articles plus 3 unpublished records.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of herbal dentifrice on the prevention of plaque and gingivitis as compared to conventional dentifrice: A systematic review and meta-analysis

Mehta

Shetiya

Kakodkar

et al. 2018

J Indian Soc Periodontol

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Objective:The aim of this study was to review literature on the effects of herbal dentifrice compared to conventional dentifrice on plaque and gingival inflammation.Materials and Methods:MEDLINE, Cochrane Central Register of Controlled Trials, and major journals were explored for studies up to September 30, 2017. A comprehensive search was designed and the articles were independently screened for eligibility by two reviewers. Randomized controlled clinical trials, in which oral prophylaxis was undertaken before the intervention was introduced into the oral cavity using toothbrush were included. Where appropriate, a meta-analysis (MA) was performed and standardized mean differences (SMDs) were calculated.Results:Ten articles out of 1378 titles were found to meet the eligibility criteria. A MA showed that for plaque intervention the SMD was 2.14; 95% confidence interval (CI): 0.88–3.41, P = 0.0009; test for heterogeneity: P < 0.00001, I2 = 96% in favor of conventional dentifrice; and for gingival inflammation, the SMD was 1.37; 95% CI: 0.49–2.26, P = 0.002; test for heterogeneity: P < 0.00001, I2 = 94% which also was in favor of conventional dentifrice. Subgroup analysis for plaque intervention and gingival inflammation in case of long-term (more than 4 weeks and up to 6 months) and short-term effects (minimum of 4 weeks) of herbal dentifrice showed no difference when compared to conventional dentifrice.Conclusion:Currently, there is no high-quality evidence to support or abnegate the anti-plaque and anti-gingivitis effects of the herbal dentifrice.

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Section: Resultsmentioning

confidence: 99%

Efficacy of herbal dentifrice on the prevention of plaque and gingivitis as compared to conventional dentifrice: A systematic review and meta-analysis

Mehta

Shetiya

Kakodkar

et al. 2018

J Indian Soc Periodontol

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“…Wogonoside is a main constituent of the herb [2,3,6] . In this study, using a panel of human cancer cell lines selected from three of the most common human cancers, including colorectal cancer (SW-480, HCT-116 and HT-29), non-small cell lung cancer (NSCLC), and breast cancer (MCF-7 and MDA-MB-231), we observed that wogonoside did not show obvious antiproliferative effects.…”

Section: Discussionmentioning

confidence: 99%

Deglycosylation of wogonoside enhances its anticancer potential

et al. 2018

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Introduction Scutellaria baicalensis is commonly used in Asia as an herbal medicine to treat a variety of ailments, including cancer. Wogonoside, one major constituent of Scutellaria baicalensis, can be primarily converted to wogonin through deglycosylation via enteric microbiome metabolism. Materials and Methods The antiproliferative effects of the glycoside (wogonoside) and its deglycosylated compound (wogonin) on a panel of human cancer cell lines from the most common solid tumors were evaluated using the MTS method. Cell cycle and apoptosis were determined using flow cytometry. Enzymatic activities of caspases were measured, and the interactions of wogonin and caspases were explored by a docking analysis. Results Wogonoside did not have obvious antiproliferative effects on the cancer cells. In contrast, wogonin showed significant antiproliferative activities on all the tested cancer cells. Wogonin arrested the cells in the G1 phase and significantly induced cell apoptosis. The compound also activated the expression of caspases 3 and 9. The docking results suggest that the compound forms hydrogen bonds with Phe250 and Ser251, and π-π interactions with Phe256 in caspase 3, and with Asp228 in caspase 9. Conclusions After wogonoside deglycosylation, wogonin significantly enhanced its anticancer potential as a potent anticancer compound derived from S. baicalensis.

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“…Therapeutic approaches aimed at modulating the host response, did involve polyphenols from Cranberries (Vaccinium macrocarpon) extracts, and led to beneficial effects slowing the periodontal disease progression [162]. In this field, polyphenols have also been considered for applications [163] in helping to control the oral hygiene, through the use of toothpastes enriched with 0.1% extracts containing naringenin and quercetin [164] and 0.5% extracts containing baicalein, baicalin, and wogonin [165] and through the use of polyphenol-containing gels [166].…”

Section: Development Of Ti Surfaces Functionalized With Polyphenolsmentioning

confidence: 99%

Potentials of Polyphenols in Bone-Implant Devices

Torre¹,

Iviglia²,

Cassinelli³

et al. 2018

Polyphenols

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Knowledge of bioactive plant-derived polyphenols is growing to such an extent that science interest is looking at development of different applications in regenerative medicine through new and state-of-the-art tissue engineering technologies. Due to their well-established and demonstrated antioxidant and anti-inflammatory beneficial properties, polyphenols have been extensively investigated to the extent that they provide benefits to different pathological conditions, including cardiovascular and bone diseases, neurodegenerative disorders, and cancer. By taking into account the main molecular pathways of polyphenols' action, we want to focus this chapter on applications of polyphenols in boneimplant devices. In particular, results of polyphenols' effects on bone cells and tissues following local delivery from innovative biomaterials will be discussed, together with preliminary in vivo tests. Purpose of the dissertation is to provide the reader new insights into knowledge of polyphenols not only regarding the different molecular mechanisms involved in their action but also the biological responses deriving from local applications.

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Clinical and antibacterial effect of an anti-inflammatory toothpaste formulation with Scutellaria baicalensis extract on experimental gingivitis

Cited by 36 publications

References 25 publications

Efficacy of herbal dentifrice on the prevention of plaque and gingivitis as compared to conventional dentifrice: A systematic review and meta-analysis

Efficacy of herbal dentifrice on the prevention of plaque and gingivitis as compared to conventional dentifrice: A systematic review and meta-analysis

Deglycosylation of wogonoside enhances its anticancer potential

Potentials of Polyphenols in Bone-Implant Devices

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