Clinical and Anatomical Correlates of Gait Dysfunction in Alzheimer's Disease

Olazarán, Javier; Hernández-Tamames, Juan Antonio; Molina, E. J.; García‐Polo, Pablo; Dobato, José Luis; Álvarez‐Linera, Juan; Martinez‐Martín, Pablo

doi:10.3233/jad-2012-121207

Cited by 32 publications

(20 citation statements)

References 37 publications

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“…The volume of their hippocampus was measured and corrected for their intracranial volume. Individual hippocampal atrophy was assessed using voxel-based morphometry, as described in (Olazaran et al, 2013). Hippocampal volume measurements were calculated using the freely available software FreeSurfer (http://surfer.nmr.mgh.harvard.edu/).…”

Section: Additional Analysismentioning

confidence: 99%

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test

Parra

Calia

Garcia

et al. 2019

Archives of Gerontology and Geriatrics

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Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). We compared data from two studies on temporary binding which assessed people with MCI and controls using different memory loads (2 or 3 items). Selective binding impairments were found in MCI, but relative to controls, such selectivity was contingent upon memory load (i.e., present with 2 items). Further analysis with MCI people who tested positive to neuroimaging biomarkers (i.e., hippocampal atrophy) confirmed that this specific binding impairments are a feature of prodromal AD. The temporary binding task has been recently suggested by consensus papers as a potential screening tool for AD. The results presented here inform on task properties that can maximise the reliability of this new assessment tool for the detection of memory impairments in prodromal cases of AD.

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Section: Additional Analysismentioning

confidence: 99%

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test

Parra

Calia

Garcia

et al. 2019

Archives of Gerontology and Geriatrics

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“…[6][7][8][9] There is an increasing understanding that motor impairments contribute to overall AD severity, and that there is a need for ameliorating these impairments. For example, gait impairments can decrease quality of life by reducing mobility; increasing risk for injuries due to falling and increasing the likelihood of institutionalization once the ability to walk is lost 10,11 . Motor dysfunction is a reliable predictor for the development of AD, and can also predict levels of cognitive dysfunction and mortality risk.…”

Section: Introductionmentioning

confidence: 99%

Age‐related deterioration of motor function in male and female 5xFAD mice from 3 to 16 months of age

O’Leary

Mantolino

Stover

et al. 2018

Genes Brain and Behavior

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Alzheimer's disease (AD) is a neurodegenerative disorder that leads to age‐related cognitive and sensori‐motor dysfunction. There is an increased understanding that motor dysfunction contributes to overall AD severity, and a need to ameliorate these impairments. The 5xFAD mouse develops the neuropathology, cognitive and motor impairments observed in AD, and thus may be a valuable animal model to study motor deficits in AD. Therefore, we assessed age‐related changes in motor ability of male and female 5xFAD mice from 3 to 16 months of age, using a battery of behavioral tests. At 9‐10 months, 5xFAD mice showed reduced body weight, reduced rearing in the open‐field and impaired performance on the rotarod compared to wild‐type controls. At 12‐13 months, 5xFAD mice showed reduced locomotor activity on the open‐field, and impaired balance on the balance beam. At 15‐16 months, impairments were also seen in grip strength. Although sex differences were observed at specific ages, the development of motor dysfunction was similar in male and female mice. Given the 5xFAD mouse is commonly on a C57BL/6 × SJL hybrid background, a subset of mice may be homozygous recessive for the Dysf im mutant allele, which leads to muscular weakness in SJL mice and may exacerbate motor dysfunction. We found small effects of Dysf im on motor function, suggesting that Dysf im contributes little to motor dysfunction in 5xFAD mice. We conclude that the 5xFAD mouse may be a useful model to study mechanisms that produce motor dysfunction in AD, and to assess the efficacy of therapeutics on ameliorating motor impairment.

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“…Although cognitive symptoms are primary, studies have shown that walking difficulties and motor dysfunction are also common [1, 2]. These mobility impairments may have a common cause with cognitive decline [3] and may be closely associated with neurodegeneration and AD pathology AD, including gray matter degeneration, white matter damage, and amyloid-beta accumulation [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Daily Physical Activity Patterns During the Early Stage of Alzheimer’s Disease

Varma

Watts

2016

JAD

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Background Alzheimer’s disease (AD) is a neurodegenerative disease that results in severe disability. Very few studies have explored changes in daily physical activity patterns during early stages of AD when components of physical function and mobility may be preserved. Methods Patients with mild AD and controls (n=92) recruited from the University of Kansas Alzheimer’s Disease Center Registry, wore the Actigraph GT3X+ for seven days, and provided objective physical function (VO2 max) and mobility data. Using multivariate linear regression, we explored whether individuals with mild AD had different daily average and diurnal physical activity patterns compared to controls independent of non-cognitive factors that may affect physical activity, including physical function and mobility. Results We found that mild AD was associated with less moderate-intensity physical activity (p<0.05), lower peak activity (p<0.01), and lower physical activity complexity (p<0.05) particularly during the morning. Mild AD was not associated with greater sedentary activity or less lower-intensity physical activity across the day after adjusting for non-cognitive covariates. Conclusions These findings suggest that factors independent of physical capacity and mobility may drive declines in moderate-intensity physical activity, and not lower-intensity or sedentary activity, during the early stage of AD. This underscores the importance of a better mechanistic understanding of how cognitive decline and AD pathology impact physical activity. Findings emphasize the potential value of designing and testing time-of-day specific physical activity interventions targeting individuals in the early stages of AD, prior to significant declines in mobility and physical function.

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Clinical and Anatomical Correlates of Gait Dysfunction in Alzheimer's Disease

Cited by 32 publications

References 37 publications

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test

Age‐related deterioration of motor function in male and female 5xFAD mice from 3 to 16 months of age

Daily Physical Activity Patterns During the Early Stage of Alzheimer’s Disease

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