Clinical and analytical follow‐up of 25 persons exposed accidentally to beryllium†

Zorn, H.; Stiefel, Th.; Porcher, H.

doi:10.1080/02772248609357156

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…One explanation remains in the relative solubility of BeAl which may lead to low accumulation in lung and as its consequence a higher concentration in kidneys and blood. Inhaled water-soluble Be salts are excreted mainly by the kidneys, with a half-life of 2-8 weeks (Zorn et al, 1986). Also, it seems evident that urinary Be declined rapidly after the cessation of exposure.…”

Section: −1mentioning

confidence: 98%

Urinary levels, tissue concentrations and lung inflammation after nose‐only exposure to three different chemical forms of beryllium

Müller¹,

Mazer²,

Salehi³

et al. 2010

J of Applied Toxicology

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This study aimed to determine the toxicity and toxicokinetic of three Be chemical species A total of 120 mice (four groups of 30) were nose-only exposed. The first group was used as a control while the three others were exposed to 250 microg m(-3) of fine particles of three different Be species (Be metal, Be-F; Be oxide, BeO-F; Be aluminium, BeAl-F). Exposure lasted over three consecutive weeks, five days per week and 6 h per day. Blood and several tissues were collected one week after exposure. Urines were collected before the beginning of exposure, at the end of every week of exposure and one week after exposure. Results showed that urine concentrations were different from one Be species to another and that excretion continued after the end of exposure. Except for BeO-F, where Be urine concentrations were stable during the three weeks of exposure, concentrations of Be-F and BeAl-F reached a peak after the first week. According to particle size, BeO-F obtained the highest theoretical pulmonary deposition rate, which partially led to the highest Be lung concentration. This group also presented the lowest urine concentration but that did not lead to more severe lung inflammation. Moreover, even if BeAl-F obtained the lowest percentage theoretical pulmonary deposition, it showed the highest Be urinary concentration, the lowest Be lung concentration and the lowest lung toxicity. In this specific case, a high Be concentration in urine did not reflect a high exposure or a severe toxic effect.

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Section: −1mentioning

confidence: 98%

Urinary levels, tissue concentrations and lung inflammation after nose‐only exposure to three different chemical forms of beryllium

Müller¹,

Mazer²,

Salehi³

et al. 2010

J of Applied Toxicology

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Beryllium

Mroz¹,

Balkissoon²,

Newman³

2001

Patty's Toxicology

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Beryllium, found in a variety of different forms, has become indispensable in modern high‐technology industries, especially aerospace. It has many attractive properties, including light weight, high strength, and heat resistance. Unfortunately, beryllium is associated with a number of toxic effects. Even under controlled conditions, beryllium metal, oxide, and alloys can cause chronic lung disease among individuals exposed to dust or fume. Identifying properties of different forms of beryllium are listed in Sections the first followed by sections, which describe the properties and characteristics of beryllium per se. These include production and use, toxic effects, standard and exposure assessment.

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Clearance, translocation, and excretion of beryllium following acute inhalation of beryllium oxide by beagle dogs*1

Finch

1990

Fundamental and Applied Toxicology

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Clinical and analytical follow‐up of 25 persons exposed accidentally to beryllium†

Cited by 7 publications

References 6 publications

Urinary levels, tissue concentrations and lung inflammation after nose‐only exposure to three different chemical forms of beryllium

Urinary levels, tissue concentrations and lung inflammation after nose‐only exposure to three different chemical forms of beryllium

Beryllium

Clearance, translocation, and excretion of beryllium following acute inhalation of beryllium oxide by beagle dogs*1

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