Abstract:Background: Plasma phosphorylated Tau (P-tau) protein is a promising biomarker for early detection of Alzheimer's Disease (AD), reflecting abnormal tau metabolism in CSF and brain. Different Tau isoforms have been shown as specific biomarkers to detect AD including plasma tau phosphorylated at threonine 181 (P-tau181) and at threonine 217 (P-tau217). Novel plasma tests have been developed on various platforms for different isoforms and using various reagents, but these have not been compared directly for their… Show more
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