Clinical analysis of Tripterygium wilfordii polyglycosides combined with immunosuppressant in the treatment of rheumatoid arthritis

Effectiveness and safety of 99Tc-methylene diphosphonate as a disease-modifying anti-rheumatic drug (DMARD) in combination with conventional synthetic (cs) DMARDs in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of 34 randomized controlled trials

“…Ten studies used MTX as the combined csDMARD [ 8 , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ], 12 used MTX combined with LEF [ [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] ], and 5 studies used MTX and SASP [ [33] , [34] , [35] , [36] , [37] ]. Only 1 study used MTX combined with HCQ as the combined csDMARDs [ 38 ], 1 used MTX and TG [ 39 ], and 1 used MTX and IGU [ 40 ]. Therefore, 2 studies used LEF as the csDMARD for combination treatment [ 41 , 42 ], 1 used TG [ 43 ], and 1 used LEF and IGU [ 44 ].…”

“…Seven studies [ 13 , 15 , 23 , 24 , 27 , 30 , 32 ] used a random number table, one study [ 8 ] used SAS software for randomization, and the remaining studies did not specify the randomization method. One study [ 8 ] used a unique code number for allocation concealment, one study [ 40 ] used random envelope allocation, and the remaining studies did not disclose the allocation concealment plan.…”

“…One study [ 8 ] was considered to have overall low risk due to the use of double-blind multicentre methods. One study [ 22 ] was double-blind, while four studies [ 28 , 35 , 39 , 40 ] were single-blind, but none reported specific blinding procedures; thus, these five studies were considered to have potential biases in the intervention measures. Moreover, three studies [ 8 , 32 , 33 ] reported dropouts or patients lost to follow-ups, and all studies reported using full data.…”

“…Ten RCTs [ 8 , 13 , 15 , 19 , 28 , 33 , 38 , 40 , 42 , 43 ] compared ACR50 scores between the csDMARD-alone group and the 99Tc-MDP combination group. There was a significant improvement in the ACR50 score in the 99Tc-MDP combination group compared with the csDMARD-alone group [RR = 1.32, 95 % CI: 1.13–1.55, P = 0.0004, Fig.…”

Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

“…The active ingredient of leigongteng, a herbal medicine commonly used in RA treatment, has been developed as a leigongteng polyglucoside, which can be used in the clinical treatment of RA ( 255 ). Celastrol (Cel) is a quinone-methylated triterpenoid extracted from Tripterygium wilfordii that has been shown to alleviate inflammatory response in RA by inhibiting the ROS/NF-κB/NLRP3 axis ( 256 ).…”