Clinical analysis of primitive neuroectodermal tumors in the female genital tract: A report of three cases

Özgü, Emre; Özgü, Burçin Salman; Halisdemir, Beril; Kale, İbrahim; Bayramoǧlu, Hati̇ce; Güngör, Tayfun

doi:10.1016/j.tjog.2015.10.014

Cited by 1 publication

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“…Reports with incomplete information about chemotherapy were also excluded. Of a total of 178 papers identified from the search terms in the MEDLINE database, 49 cases fulfilled the mentioned criteria (Table ). We analyzed the choice of chemotherapy regimen in relation to the patients’ ages and divided patients into the following groups: adolescence (<20 years), reproductive (20–40 years), premenopausal (40–60 years) and elderly (>60 years).…”

Section: Discussionmentioning

confidence: 99%

Adjuvant chemotherapy for a primitive neuroectodermal tumor of the uterine corpus: A case report and literature review

Akazawa

Saito

Ariyoshi

et al. 2018

J of Obstet and Gynaecol

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A primitive neuroectodermal tumor (PENT) belongs to the category of a Ewing sarcoma. A PENT of the uterus is rare and has been known to be very aggressive by nature. Owing to the rarity of the tumor, there is no optimal treatment at present. In many cases, after hysterectomy, chemotherapy or radiation therapy has been performed. However, an effective chemotherapy regimen was unclear. In the soft tissue sarcoma area, the chemotherapy approach has recently greatly improved. Vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VDC-IE) therapy has improved the survival rate of patients with Ewing sarcoma/PENT. Thus, VDC-IE therapy may be used for a uterine PENT. Here, we report a case of a uterine PENT in a premenopausal woman successfully treated with multimodality treatment including VDC-IE therapy and discuss the optimal chemotherapy for a uterine PENT through a literature review.

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Section: Discussionmentioning

confidence: 99%