Clinical analysis of postoperative venous thromboembolism in Japanese patients after colorectal cancer surgery

Yamashita, Shoko; Nishi, Masaaki; Ikemoto, Tetsuya; Yoshikawa, Kozo; Higashijima, Jun; Tokunaga, Takuya; Takasu, Chie; Kashihara, Hideya; Eto, Shohei; Yoshimoto, Toshiaki; Shimada, Mitsuo

doi:10.1007/s00595-020-02201-5

Cited by 10 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to previous studies, DVT rarely occurs in patients with various cancers, such as breast, prostate, and colorectal cancers (10,18,26,30,36). A study shows that in 9,735 patients with cancer (such as colorectal, lung, stomach, pancreatic, breast, and gynecologic cancers), the DVT incidence is 5.2% in Japan (37).…”

Section: Discussionmentioning

confidence: 99%

“…It could be explained by that the conditions of medical care varied in different countries, resulting in the different LDVT incidences in breast cancer. With respect to the demographic and tumor features, they are related to DVT in patients with cancer (18,30,(38)(39)(40)(41). For instance, older age, obesity, and hyperlipidemia are independent risk factors for DVT in surgical colorectal cancer patients (18,30).…”

Section: Discussionmentioning

confidence: 99%

“…With respect to the demographic and tumor features, they are related to DVT in patients with cancer (18,30,(38)(39)(40)(41). For instance, older age, obesity, and hyperlipidemia are independent risk factors for DVT in surgical colorectal cancer patients (18,30). Moreover, the preoperative Frankel score, blood transfusion, Charlson comorbidity index, and operative time are four independent risk factors for DVT in patients with postoperative breast and cervical cancer (41).…”

Section: Discussionmentioning

confidence: 99%

“…Among 491 patients with breast cancer who underwent surgical resection, there were only 11 (2.2%) patients who occurred LDVT and 480 (97.8%) patients who did not occur LDVT (Figure 1). Meanwhile, the incidence of venous thromboembolism (VTE) in cancer patients from previous studies (10,26,(30)(31)(32)(33)(34) is listed in Supplementary Table S1.…”

Section: Ldvt Incidencementioning

confidence: 99%

See 3 more Smart Citations

Incidence and Related Factors for Low-Extremity Deep Vein Thrombosis in Breast Cancer Patients Who Underwent Surgical Resection: What Do We Know and What Should We Care

et al. 2022

View full text Add to dashboard Cite

Malignancy, surgical resection, and neoadjuvant and/or adjuvant chemotherapy increase the low-extremity deep vein thrombosis (LDVT) risk in patients with breast cancer, bringing in great physical burdens, disabilities, and worse survivals. However, LDVT in surgical breast cancer patients is scarcely reported. Therefore, this study aimed to evaluate the incidence and related factors for LDVT in these patients. Patients with breast cancer who underwent surgical resection were included. LDVT was examined on the day of discharge and 1 month after the discharge. A total of 491 eligible patients were included, among which 11 (2.2%) patients occurred LDVT. Besides, higher age, history of diabetes mellitus, advanced T and tumor node metastasis (TNM) stages, higher platelet count, and shorter activated partial thromboplastin time (APTT) were correlated with increased LDVT incidence (all p < 0.05). Additionally, higher age [p = 0.004, odds ratio (OR) (95% CI): 1.082 (1.023–1.144)], history of diabetes mellitus [p = 0.003, OR (95% CI): 10.426 (2.219–48.986)], and a higher platelet count [p = 0.008, OR (95% CI): 1.017 (1.004–1.029)] were independent factors for increased LDVT incidence, while higher APTT [p = 0.004, OR (95% CI): 0.636 (0.467–0.866)] was an independent factor for decreased LDVT incidence. Lastly, the risk prediction model involving age, history of diabetes mellitus, platelet count, and APTT showed a good ability to predict LDVT occurrence (area under curve: 0.919, 95% CI: 0.869–0.968). In conclusion, the LDVT incidence is 2.2%, and its independent factors consist of age, history of diabetes mellitus, platelet count, and APTT in patients with breast cancer who underwent surgical resection, which provides evidence for the prevention and surveillance of LDVT in surgical breast cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Ldvt Incidencementioning

confidence: 99%

See 2 more Smart Citations

Incidence and Related Factors for Low-Extremity Deep Vein Thrombosis in Breast Cancer Patients Who Underwent Surgical Resection: What Do We Know and What Should We Care

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In addition, pulmonary artery embolisms are potentially lethal. Obesity has been shown to be a risk factor for venous thromboembolisms in the long-term outcome after colorectal surgery [71]. Therefore, the prophylactic use of low-molecular weight heparin is recommended in such cases [72].…”

Section: Confounding Factors Affecting Postoperative Outcomementioning

confidence: 99%

Impact of Excess Body Weight on Postsurgical Complications

Plassmeier

Hankir

Seyfried³

2021

Visc Med

View full text Add to dashboard Cite

Background: Obesity is considered a risk factor for postoperative complications as it can limit exposure to the operation field, thereby significantly prolonging surgery time. Obesity-associated comorbidities, such as low-grade systemic inflammation, impaired functional status, and type 2 diabetes, are independent risk factors for impaired anastomotic wound healing and nonsurgical site infections. If obesity itself is an independent risk factor for surgical complications remains controversial, but the reason for this is largely unexplored. Summary: A MEDLINE literature search was performed using the terms: “obesity,” “excess body weight,” and “surgical complications.” Out of 65,493 articles 432 meta-analyses were screened, of which 25 meta-analyses were on the subject. The vast majority of complex oncologic procedures in the field of visceral surgery have shown higher complication rates in obese patients. Meta-analyses from the last 10 to 15 years with high numbers of patients enrolled consistently have shown longer operation times, higher blood loss, longer hospital stay for colorectal procedures, oncologic upper gastrointestinal (GI) procedures, and pancreatic surgery. Interestingly, these negative effects seem not to affect the overall survival in oncologic patients, especially in esophageal resections. A selection bias in oncologic upper GI patients may have influenced the results with higher BMI in upper GI cancer to be a predictor for better nutritional and performance status. Key Messages: Contrary to bariatric surgery, only limited evidence indicated that site and type of surgery, the approach to the abdominal cavity (laparoscopic vs. open), institutional factors, and the type of perioperative care such as ERAS protocols may play a role in determining postsurgical complications in obese patients. The initial question remains therefore partially unanswered. Large nationwide register-based studies are necessary to better understand which aspects of obesity and its related comorbidities define it as a risk factor for surgical complications.

show abstract

Risk factors for postoperative proximal deep vein thrombosis and pulmonary embolism after laparoscopic colorectal cancer surgery: analysis of a multicenter randomized controlled trial

et al. 2021

View full text Add to dashboard Cite

Clinical analysis of postoperative venous thromboembolism in Japanese patients after colorectal cancer surgery

Cited by 10 publications

References 19 publications

Incidence and Related Factors for Low-Extremity Deep Vein Thrombosis in Breast Cancer Patients Who Underwent Surgical Resection: What Do We Know and What Should We Care

Incidence and Related Factors for Low-Extremity Deep Vein Thrombosis in Breast Cancer Patients Who Underwent Surgical Resection: What Do We Know and What Should We Care

Impact of Excess Body Weight on Postsurgical Complications

Risk factors for postoperative proximal deep vein thrombosis and pulmonary embolism after laparoscopic colorectal cancer surgery: analysis of a multicenter randomized controlled trial

Contact Info

Product

Resources

About