Clinical Analysis of Living Related Renal Transplantation With Donors Older Than 50 Years in China

Guo, Feng; Shao, Zhiqiang; Wen-yan, Yang; Wang, G.-J.; Tan, Shanfeng; He, Xiaofeng; Wang, J.-M.; Liu, H.J.; Li, Y.; Sun, Fu-guang; Zhu, Wen

doi:10.1016/j.transproceed.2010.04.038

Cited by 5 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four studies 18 , 28 , 30 investigating effect of age on serum creatinine concentration met the inclusion criteria. The first two 18 , 28 compared serum creatinine levels before and 1 year after LKD in donors who were younger or older than 60 years.…”

Section: Resultsmentioning

confidence: 99%

Risks for donors associated with living kidney donation: meta-analysis

Bellini

Nozdrin

Pengel

et al. 2022

British Journal of Surgery

View full text Add to dashboard Cite

Background Living kidney donation risk is likely to differ according to donor’s demographics. We aimed to analyse the effects of age, sex, body mass index (BMI) and ethnicity. Methods A systematic review and meta-analysis was undertaken of the effects of preoperative patient characteristics on donor kidney function outcomes, surgical complications, and hypertension. Results 5129 studies were identified, of which 31 met the inclusion criteria, mainly from the USA and Europe. The estimated glomerular filtration rate (eGFR) in donors aged over 60 years was a mean of 9.54 ml per min per 1.73 m2 lower than that of younger donors (P < 0.001). Female donors had higher relative short- and long-term survival. BMI of over 30 kg/m2 was found to significantly lower the donor’s eGFR 1 year after donation: the eGFR of obese donors was lower than that of non-obese patients by a mean of −2.70 (95 per cent c.i. −3.24 to −2.15) ml per min per 1.73 m2 (P < 0.001). Obesity was also associated with higher blood pressure both before and 1 year after donation, and a higher level of proteinuria, but had no impact on operative complications. In the long term, African donors were more likely to develop end-stage renal disease than Caucasians. Conclusion Obesity and male sex were associated with inferior outcomes. Older donors (aged over 60 years) have a larger eGFR decline than younger donors, and African donors have a higher incidence of ESRD than Caucasians.

show abstract

Section: Resultsmentioning

confidence: 99%

Risks for donors associated with living kidney donation: meta-analysis

Bellini

Nozdrin

Pengel

et al. 2022

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…Four studies[ 15 , 16 , 20 , 35 ] compared 1-year serum creatinine in recipients of renal grafts from donors aged < 50 and donors aged > 50 years, finding the former on average 0.14 mg/dl lower than that of recipients of donors aged > 50 (p = 0.003) (Fig. 2 l).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies reported the effect of donor age and recipient survival [14][15][16][17][18][19]; Grekas et al [14], Johnson et al [15] and Guo et al [16] compared recipient survival from donors aged above/below 50 years (Fig. 2a).…”

Section: Effect Of Donor Agementioning

confidence: 99%

See 1 more Smart Citation

How good is a living donor? Systematic review and meta-analysis of the effect of donor demographics on post kidney transplant outcomes

et al. 2022

View full text Add to dashboard Cite

Background and Aims Living donor kidneys are considered the best quality organs. In the attempt to expand the donor pool, the donor’s age, sex and body mass index (BMI) might be considered as potential determinants of the kidney transplant outcomes, and thus guide recipient selection. We aimed to investigate the effects of donor demographics on kidney function, graft and recipient survival, delayed graft function (DGF) and acute rejection (AR). Methods Systematic review and meta-analysis. EMBASE, MEDLINE, Web of Science, BIOSIS, CABI, SciELO and Cochrane were searched using algorithms. NHBLI tools were used for risk of bias assessment. Mean difference (MD), standardized mean difference (SMD), and risk ratio (RR) were calculated in Revman 5.4 Results Altogether, 5129 studies were identified by the search algorithm; 47 studies met the inclusion criteria and were analyzed. No significant difference in recipient 1-year survival was found between recipients of donors aged < 50 vs donors aged > 50 (RR = 0.65 95% CI: 0.1–4.1), and recipients of donors aged < 60 vs donors aged > 60 (RR = 0.81 95% CI: 0.3–2.3). Graft survival was significantly higher in recipients of grafts from donors aged < 60. Risk of AR (RR = 0.62 95% CI: 0.5–0.8) and DGF (RR = 0.28 95% CI: 0.1–0.9) were significantly lower in recipients of grafts from donors aged < 60. One-year serum creatinine was significantly lower in recipients from donors aged < 60 years compared to donors aged > 60 years (MD = 0.3 mg/dl 95% CI: 0.1–0.9), although there was high heterogeneity. Recipients of grafts from male donors had lower 1-year serum creatinine (MD = 0.12 mg/dl 95% CI: 0.2–0.1) and higher eGFR compared to recipients of female donors (p < 0.00001). Donor obesity increased the incidence of delayed graft function but not acute rejection (RR = 0.66 95% CI: 0.32–1.34). Conclusions Older donor age was associated with worse post-transplant outcomes and recipients of male donors had better 1-year eGFR. Donor obesity affects the incidence of delayed graft function, but not the incidence of acute rejection in recipients. Graphical Abstract

show abstract

“…According to incomplete statistics in China, approximately 150 thousand and 500 thousand patients die from uremia and type B nephritis associated end-stage renal diseases every year [1]. At present, success rate of kidney transplant surgeries in China is 85%, 1-year and 3-year survival rates of the benign renal diseases after transplantations are 90% and 80.5%, respectively [2,3].…”

Section: Introductionmentioning

confidence: 99%

Side Effects of Immunosuppressive Regimens After Renal Transplantation and Multiple-Sample Assessment of Quality of Life

Wei¹

2017

AJCEM

View full text Add to dashboard Cite

Abstract:Influences of the side effects and interferences of immunosuppressants on the quality of life (QOL) of renal transplant recipients have been discussed. 72 renal transplant recipients were surveyed utilizing 25-item health status questionnaires, and modified transplant symptom occurrence and symptom distress scales. The results showed that the frequencies and symptom interferences of side effect after receiving immunosuppressants were below medium level. Physical and mental health related QOL was most significantly affected by symptom occurrence and symptom distress, respectively. Besides, postoperative comorbidity, work status, age and household income have also been demonstrated to be able to predict the postoperative QOL. Side effects all occurred to various extents after receiving immunosuppressants to the renal transplant recipients, the occurrence and interference of the symptoms were not apparent, which would affect the postoperative QOL.

show abstract

Clinical Analysis of Living Related Renal Transplantation With Donors Older Than 50 Years in China

Cited by 5 publications

References 19 publications

Risks for donors associated with living kidney donation: meta-analysis

Risks for donors associated with living kidney donation: meta-analysis

How good is a living donor? Systematic review and meta-analysis of the effect of donor demographics on post kidney transplant outcomes

Side Effects of Immunosuppressive Regimens After Renal Transplantation and Multiple-Sample Assessment of Quality of Life

Contact Info

Product

Resources

About