Clinical analysis of leg ulcers and gangrene in rheumatoid arthritis

Hasegawa, Michiko; Nagai, Yayoi; Sogabe, Yoko; Hattori, Tomoyasu; Inoue, Chizuru; Okada, Etsuko; Tago, Osamu; Ishikawa, Osamu

doi:10.1111/1346-8138.12359

Cited by 10 publications

(1 citation statement)

References 17 publications

(34 reference statements)

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“…A total of 3212 unique citations were found. 1286 and 1704 citations were excluded by abstract and full‐text read, respectively, yielding 222 articles…”

Section: Resultsmentioning

confidence: 99%

Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi‐systematic review

Abdallah

Fogh

Bech

2019

International Wound Journal

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Pyoderma gangrenosum (PG) is a rare ulcerative skin disease that presents a therapeutic challenge. Tumour necrosis factor alpha (TNFα) inhibitors have been reported to successfully control PG. Our aim was to systematically evaluate and compare the clinical effectiveness of TNFα inhibitors in adults with PG. A literature search including databases such as PubMed, Embase, Scopus, and Web of Science was conducted, using search terms related to PG and TNFα inhibitors. Studies and case reports were included if patients were diagnosed with PG, over the age of 18 and administered TNFα inhibitor. A total of 3212 unique citations were identified resulting in 222 articles describing 356 patients being included in our study. The study we report found an 87% (95% CI: 83%‐90%) response rate and a 67% (95% CI: 62%‐72%) complete response rate to TNFα inhibitors. No statistically significant differences in the response rates (P = 0.6159) or complete response rates (P = 0.0773) to infliximab, adalimumab, and etanercept were found. In our study TNFα inhibitors demonstrated significant effectiveness with response and complete response rates supporting the use of TNFα inhibitors to treat PG in adults. Our study suggests that there is no significant difference in effectiveness among infliximab, adalimumab, and etanercept.

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“…A total of 3212 unique citations were found. 1286 and 1704 citations were excluded by abstract and full‐text read, respectively, yielding 222 articles…”

Section: Resultsmentioning

confidence: 99%

Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi‐systematic review

Abdallah

Fogh

Bech

2019

International Wound Journal

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The Skin and Disorders of the Musculoskeletal System

Lovell

2016

Rook's Textbook of Dermatology, Ninth Edition

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Rheumatological conditions such as tophaceous gout may present initially to the dermatologist; combined clinics with rheumatology are of great value. In addition to autoimmune connective diseases such as systemic lupus and dermatomyositis, several infections and inflammatory conditions present with both skin and joint involvement. Several antirheumatic therapies are associated with cutaneous adverse effects.

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The Skin and Disorders of the Musculoskeletal System

Lovell

2024

Rook's Textbook of Dermatology

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Combined dermatology/rheumatology clinics are valuable for patients with complex disease. Direct questioning about musculoskeletal symptoms should complement a dermatological and occupational history. Musculoskeletal examination includes posture and gait, localisation of pain, the presence and pattern of joint swelling, deformity or restricted movement, and muscle wasting or weakness. Specific patterns of skin and joint involvement are seen in infective arthropathies, including the acute spondylarthritis that may follow a genitourinary or gastrointestinal infection. Rheumatoid arthritis affects the skin in several ways including subcutaneous nodules, vasculitis, neutrophilic dermatosis and leg ulceration. Metabolic disorders, including alkaptonuria and tophaceous gout, affect both skin and joints. Autoinflammatory disorders may be hereditary or acquired (including acne and hidradenitis suppurativa). Relapsing polychondritis presents as recurrent chondritis of the pinnae, nasal cartilage or respiratory tract, eye inflammation and a seronegative inflammatory arthritis. Skin reactions to antirheumatic drugs are common and may be severe, e.g. DRESS, Stevens–Johnson syndrome and toxic epidermal necrolysis.

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Clinical analysis of leg ulcers and gangrene in rheumatoid arthritis

Cited by 10 publications

References 17 publications

Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi‐systematic review

Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi‐systematic review

The Skin and Disorders of the Musculoskeletal System

The Skin and Disorders of the Musculoskeletal System

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