Clinical analysis of blood markers and imaging for diagnosis and prognosis of rheumatoid arthritis

Abstract

Background The purpose of this study is to explore the combined diagnostic value of anti-cyclic citrullinated peptide antibody (A-CCP), rheumatoid factor (RF) and imaging result in early rheumatoid arthritis, and the role of A-CCP and RF in prediction for radiological outcomes. Methods 101 patients with rheumatoid arthritis and 97 control individuals were detect their A-CCP, RF and radiological joint changes, the diagnostic efficacy of the respective indicators and the combined indicators was analyzed by logistic regression model. Results Our results showed that values of A-CCP and RF were significantly higher in the RA group than in the normal group. Receiver operating characteristic curve results show that the sensitivity of RF is higher than A-CCP and radiological outcome, and specificity of CCP is higher than RA and radiological outcome, and the diagnostic ability of combination of RF, A-CCP and radiological outcome is the strongest. Furthermore, RF and A-CCP had high significant OR for radiological joint damage and progression. Conclusions Our study indicated that the combined diagnosis of RF and A-CCP with radiological outcome can improve the diagnostic efficacy of RA, and RF and A-CCP are independent predictors of radiological damage and progression.

Early diagnosis and treatment of rheumatoid arthritis

“…The study concludes that the screening methods for RA includes IgM -RF and CCP assays which are superior to other RF isotypes. In another cross-sectional study done by Desheng Yang et al [2] , among 148 patients in Qingdao haici hospital, China, reported that the combined detection of ACCP and RF with imaging has a high diagnostic efficiency in the diagnosis of RA. ACCP and RF are commonly used indicators for the diagnosis, but any one test has its own limitations.…”

STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico

“…However, we highlight that higher CRP values in the control group were found when compared to RA patients, which is in contrast with the RA cases from the Western population included in this study and other previously studied populations. The higher CRP levels could be an indicator of metabolic disequilibrium in any inflammatory process [58][59][60].…”

Future Method of Diagnosis and Treatment of Arthritis

“…It can be done through early and accurate diagnosis in addition to taking the appropriate doses of the improved medications for rheumatism under close observation. It infects about 25 men and 54 of women among the 100,000 population [2][3][4][5].…”