Clinical Amnionitis and Endometritis in Patients With Premature Rupture of Membranes: Endocervical Prostaglandin E2 Gel Versus Oxytocin for Induction of Labor

Malik, Nisha; Gittens, Lisa; González, David Ricardo Llanos; Bardeguez, Arlene; Ganesh, Vijaya; Apuzzio, Joseph J.

doi:10.1016/0029-7844(96)00266-9

Cited by 14 publications

(4 citation statements)

References 9 publications

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“…Twenty-seven trials compared oxytocin with vaginal PGE2 (Andersen 1990; Atad 1996; Chua 1991; Egarter 1987; Ekman 1986; Ekman-Ordeberg 1985; Griffith-Jones 1990; Hannah 1996; Herabutya 1991; Jagani 1984; Lange 1984; Legarth 1987; Lyndrup 1989; Lyndrup 1990; Macer 1984; Magos 1983; McCaul 1997; McQueen 1990; Olmo 2001; Pollnow 1996; Ray 1992; Roberts 1986; Rymer 1992; Silva-Cruz 1988; Valadan 2005; Van Der Walt 1989; Wilson 1978). Fourteen trials compared oxytocin with intracervical PGE2 (Ashrafunnessa 1997; Bilgin 1996; Bung 1986; Dominguez 1999; Goeschen 1989; Jackson 1994; Magann 1995; Malik 1996; Papageorgiou 1992; Parikh 2001; Puertas 1996; Ulmsten 1979; Wiqvist 1986; Zahradnik 1987). Three trials compared oxytocin with vaginal PGFalpha (Day 1985; MacLennan 1980; Yang 1994).…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen trials compared oxytocin with intracervical PGE2 (Ashrafunnessa 1997; Bilgin 1996; Bung 1986; Dominguez 1999; Goeschen 1989; Jackson 1994; Magann 1995; Malik 1996; Papageorgiou 1992; Parikh 2001; Puertas 1996; Ulmsten 1979; Wiqvist 1986; Zahradnik 1987).…”

Section: Resultsmentioning

confidence: 99%

“…Eight trials used computer-generated lists of random numbers (Atad 1996; Hannah 1996; Ladfors 1996; Lange 1984; Magann 1995; Malik 1996; McCaul 1997; Rymer 1992). Nine used random number tables (Alcalay 1996; Day 1985; Griffith-Jones 1990; MacLennan 1980; McQueen 1990; McQueen 1992; Pollnow 1996; Ray 1992; Van Der Walt 1989).…”

Section: Resultsmentioning

confidence: 99%

“…Eight trials used computer-generated lists of random numbers (Atad 1996; Hannah 1996; Ladfors 1996; Lange 1984; Magann 1995; Malik 1996; McCaul 1997; Rymer 1992).…”

Section: Resultsmentioning

confidence: 99%

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Intravenous oxytocin alone for cervical ripening and induction of labour

Alfirević

Kelly

Dowswell

2009

Cochrane Database of Systematic Reviews

155

129

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Background Oxytocin is the commonest induction agent used worldwide. It has been used alone, in combination with amniotomy or following cervical ripening with other pharmacological or non-pharmacological methods. Objectives To determine the effects of oxytocin alone for third trimester cervical ripening and induction of labour in comparison with other methods of induction of labour or placebo/no treatment. Search methods We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (January 2009) and bibliographies of relevant papers. Selection criteria Randomised and quasi-randomised trials comparing intravenous oxytocin with placebo or no treatment, or with prostaglandins (vaginal or intracervical) for third trimester cervical ripening or labour induction. Data collection and analysis Two review authors independently assessed eligibility and carried out data extraction. Main results Sixty-one trials (12,819 women) are included. When oxytocin inductions were compared with expectant management, fewer women failed to deliver vaginally within 24 hours (8.4% versus 53.8%, risk ratio (RR) 0.16, 95% confidence interval (CI) 0.10 to 0.25). There was a significant increase in the number of women requiring epidural analgesia (RR 1.10, 95% CI 1.04 to 1.17). Fewer women were dissatisfied with oxytocin induction in the one trial reporting this outcome (5.9% versus 13.7%, RR 0.43, 95% CI 0.33 to 0.56). Compared with vaginal prostaglandins, oxytocin increased unsuccessful vaginal delivery within 24 hours in the two trials reporting this outcome (70% versus 21%, RR 3.33, 95% CI 1.61 to 6.89). There was a small increase in epidurals when oxytocin alone was used (RR 1.09, 95% CI 1.01 to 1.17). Most of the studies included women with ruptured membranes, and there was some evidence that vaginal prostaglandin increased infection in mothers (chorioamnionitis RR 0.66, 95% CI 0.47 to 0.92) and babies (use of antibiotics RR 0.68, 95% CI 0.53 to 0.87). These data should be interpreted cautiously as infection was not pre-specified in the original review protocol. When oxytocin was compared with intracervical prostaglandins, there was an increase in unsuccessful vaginal delivery within 24 hours (50.4% versus 34.6%, RR 1.47, 95% CI 1.10 to 1.96) and an increase in caesarean sections (19.1% versus 13.7%, RR 1.37, 95% CI 1.08 to 1.74) in the oxytocin group. Authors’ conclusions Comparison of oxytocin with either intravaginal or intracervical PGE2 reveals that the prostaglandin agents probably increase the chances of achieving vaginal birth within 24 hours. Oxytocin induction may increase the rate of interventions in labour. A suggestion that for women with prelabour rupture of membranes induction with vaginal prostaglandin may increase risk of infection for mother and baby warrants further study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Eight trials used computer-generated lists of random numbers (Atad 1996; Hannah 1996; Ladfors 1996; Lange 1984; Magann 1995; Malik 1996; McCaul 1997; Rymer 1992).…”

Section: Resultsmentioning

confidence: 99%

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