Clinical Ability of Pattern Electroretinograms and Visual Evoked Potentials in Detecting Visual Dysfunction in Ocular Hypertension and Glaucoma

Comparative evaluation of Optical Coherence Tomography (OCT) with Pattern Reversal Visual Evoked Potential (PRVEP) in early primary open angle glaucoma

“…In present study, we found that the latency of P100 was delayed and the amplitude of P100 was reduced in POAG patients when compared with that of control subjects, which is consistent with previous investigations reported in glaucoma patients in the past by Parisi et al, [11] , Bach [12] , http://dx.doi.org/10.21746/ijbio.2017.06.003 pg. 5397…”

Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: Implications for glaucoma

“…Three months of topical, ocular NGF treatment in 3 patients with advanced glaucoma at risk of vision loss resulted in long-lasting improvement in visual field, contrast sensitivity, and best corrected visual acuity. Despite successful IOP control by medical therapy, these patients had progressive visual field defects and severe abnormalities in PERG and VEP responses that indicated dysfunction of the innermost retinal layers, delay in visual cortical responses, and delay in neural conduction along postretinal visual pathways (24,25). In glaucoma, up to 20% of patients show progression of visual field defects with RGC and optic nerve degeneration despite successful management of ocular hypertension (26).…”

The Validity of Reliability Measure in Threshold Perimetry

“…Increased latency and decreased amplitude of P100 in P-VEP had been reported in glaucoma patients [16][17][18][19][20][21]. Furthermore, the latency of P100 in P-VEP had been used as a marker of reversible ganglion cell damage in trials of neuro-protective agents for the treatment Blood flow velocity is given in cm/second, POAG= primary open angle glaucoma, OA= ophthalmic artery, CRA= central retinal artery, SPCA= short posterior ciliary artery, PSV= peak systolic velocity, EDV= end-diastolic velocity, RI= resistive index ,* P < 0.05 of glaucoma [26].…”

“…P-VEP may reflect the function of retinal ganglion cells (RGCs) objectively and sensitively and the latency of P100 can be used as a measure of early glaucomatous damage before RGCs death. Parisi et al [16] found that the latency of P100 delayed and amplitude of P100 decreased in primary open angle glaucoma (POAG) patients comparing with that of normal subjects. The present study found that the latency of P100 delayed and amplitude of P100 decreased in POAG patients comparing with that of control subjects, which was consistent with previous investigations [16][17][18][19][20][21].…”

“…Previous studies showed that the P-VEP in glaucoma patients manifested an increased latency and decreased amplitude [16][17][18] and the P100 latency and amplitude in patients with open angle glaucoma were correlated with the visual field defect [19][20][21].…”