Clindamycin-susceptibility Rates of Methicillin-resistant Staphylococcus aureus Varies by Infection Type in Pediatric Patients

Abstract

Hospital-wide antibiograms provide general susceptibility patterns. Specific antibiograms were created for methicillin-resistant Staphylococcus aureus isolates based on infection process and epidemiology. Using clinical microbiology laboratory data and patient profiles, high clindamycin resistance rates were seen for nonskin and soft tissue infections and noncommunity-associated methicillin-resistant S. aureus isolates.

Clinical Context-Specific Staphylococcus aureus Susceptibilities May Differ Substantially and Be Obscured by Aggregate Antibiograms

“…The findings presented here are consistent with recent reports from other pediatric centers and national data trends. [3][4][5][6][7] Institutional analyses from Philadelphia 3 and Kansas City 4 similarly found clindamycin susceptibility rates for MRSA to vary substantially by infection type, with rates remaining approximately 90% for wound and SSTI specimens. Temporal data from Texas Children's Hospital indicate a substantial shift from MRSA to MSSA predominance for SSTIs and invasive infections in the past 15 years, as well as greater clindamycin resistance for MSSA than MRSA in OAIs.…”

“…Nevertheless, aggregate hospital and unit-based data may not best reflect the epidemiology of major pathogens in all clinical scenarios, including presentations in which empiric antibiotics are typically used. Though various stratifications of antibiograms have been suggested to better inform clinical practice, [1][2][3][4] -for example, by community versus healthcare association and by specimen type-such subcategorized data are less frequently available to frontline providers.…”