Clindamycin-loaded nanofibers of polylactic acid, elastin and gelatin for use in tissue engineering

Castillo‐Ortega, M. M.; López-Peña, Ignacio; Rodríguez-Félix, Dora Evelia; Castillo-Castro, T. del; Encinas, José Carmelo; Santacruz‐Ortega, Hisila; Cauich-Rodríguez, Juan Valerio; Quiroz-Castillo, Jesus Manuel; Chan-Chan, Lerma H.; Lagarda-Díaz, Irlanda; Plascencia-Martínez, D. F.; Leyva-Verduzco, A. A.

doi:10.1007/s00289-021-03734-6

Cited by 8 publications

(3 citation statements)

References 49 publications

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“…Wells without cells were used as the negative control. At 24, 48, and 72 h, cellular viability and cytotoxicity were determined by measuring the reduction of resazurin . The concentrated stock solution (4 mg/mL) of resazurin salt (Sigma-Aldrich) was diluted in the supplemented culture medium and added to each well at a final proportion 1:200.…”

Section: Methodsmentioning

confidence: 99%

“…At 24, 48, and 72 h, cellular viability and cytotoxicity were determined by measuring the reduction of resazurin. 28 The concentrated stock solution (4 mg/mL) of resazurin salt (Sigma-Aldrich) was diluted in the supplemented culture medium and added to each well at a final proportion 1:200. After 6 h of incubation, the absorbance of the samples was measured at 570 and 600 nm using a Synergy HTX multimode microplate reader (BioTek Instruments, Vermont, USA.).…”

Section: Methodsmentioning

confidence: 99%

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Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

García Verdugo,

Salazar Salas,

Chan

et al. 2024

ACS Omega

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Photothermal nanocomposite hydrogels are promising materials for remotely triggering drug delivery by nearinfrared (NIR) radiation stimuli. In this work, a novel hydrogel based on poly(vinyl alcohol), poly(vinyl methyl ether-alt-maleic acid), poly(vinyl methyl ether), and functionalized multiwalled carbon nanotubes (MWCNT-f) was prepared by the freeze/thaw method. A comparative characterization of materials (with and without MWCNT-f) was carried out by infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, mechanical assays, swelling kinetics measurements, and photothermal analysis under NIR irradiation. Hydrophilic chemotherapeutic 5-fluorouracil (5-FU) and hydrophobic ibuprofen drugs were independently loaded into hydrogels, and the drug release profiles were obtained under passive and NIR-irradiation conditions. The concentration-dependent cytotoxicity of materials was studied in vitro using noncancerous cells and cancer cells. Notable changes in the microstructure and physicochemical properties of hydrogels were observed by adding a low content (0.2 wt %) of MWCNT-f. The cumulative release amounts of 5-FU and ibuprofen from the hydrogel containing MWCNT-f were significantly increased by 21 and 39%, respectively, through the application of short-term NIR irradiation pulses. Appropriate concentrations of the nanocomposite hydrogel loaded with 5-FU produced cytotoxicity in cancer cells without affecting noncancerous cells. The overall properties of the MWCNT-f-containing hydrogel and its photothermal behavior make it an attractive material to promote the release of hydrophilic and hydrophobic drugs, depending on the treatment requirements.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

García Verdugo,

Salazar Salas,

Chan

et al. 2024

ACS Omega

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“…The antimicrobial effect was confirmed against S. aureus, and a biosafety of 87% was validated against human umbilical vein endothelial/vascular endothelium cells. The materials released the CLD and were safe to apply, despite the use of such solvents [113]. By mixing GE with polyethylene glycol dibenzaldehyde using a vortex, a stiff gel was obtained with the formation of imine bonds.…”

Section: Polymeric Carriers Of Clindamycinmentioning

confidence: 99%

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Słota,

Jampilek,

Sobczak-Kupiec

2024

IJMS

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Targeted therapy represents a real opportunity to improve the health and lives of patients. Developments in this field are confirmed by the fact that the global market for drug carriers was worth nearly $40 million in 2022. For this reason, materials engineering and the development of new drug carrier compositions for targeted therapy has become a key area of research in pharmaceutical drug delivery in recent years. Ceramics, polymers, and metals, as well as composites, are of great interest, as when they are appropriately processed or combined with each other, it is possible to obtain biomaterials for hard tissues, soft tissues, and skin applications. After appropriate modification, these materials can release the drug directly at the site requiring a therapeutic effect. This brief literature review characterizes routes of drug delivery into the body and discusses biomaterials from different groups, options for their modification with clindamycin, an antibiotic used for infections caused by aerobic and anaerobic Gram-positive bacteria, and different methods for the final processing of carriers. Examples of coating materials for skin wound healing, acne therapy, and bone tissue fillers are given. Furthermore, the reasons why the use of antibiotic therapy is crucial for a smooth and successful recovery and the risks of bacterial infections are explained. It was demonstrated that there is no single proven delivery scheme, and that the drug can be successfully released from different carriers depending on the destination.

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Co-electrospun nanofibers of gelatin and chitosan–polyvinyl alcohol–eugenol for wound dressing applications

et al. 2022

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Clindamycin-loaded nanofibers of polylactic acid, elastin and gelatin for use in tissue engineering

Cited by 8 publications

References 49 publications

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Co-electrospun nanofibers of gelatin and chitosan–polyvinyl alcohol–eugenol for wound dressing applications

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