Clindamycin and nicotinic neuromuscular transmission

Schulze, Johannes; Toepfer, Marcell; Kc, Schroff; Aschhoff, Susanne; Remien, Jörg; Müller‐Felber, Wolfgang; Endres, Stefan

doi:10.1016/s0140-6736(99)02881-0

Cited by 25 publications

(6 citation statements)

References 3 publications

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“…Clindamycin and aminoglycoside antibiotics can enhance muscle relaxant function (Singh et al, 1978;Schulze et al, 1999). These antibiotics inhibit the release of acetylcholine from the motor nerve terminals by binding to calcium ions on the surface of presynaptic membranes (Pridgen, 1956).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Cigarette Smoking on Steroidal Muscular Relaxants and Antibiotics Used: A Prospective Cohort Study

et al. 2021

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Background: The impact of cigarette smoking on perianesthesia management is not clear elucidated. This paper studies the impact of long-term cigarette smoking on the dose-response of rocuronium and vecuronium used under general anesthesia and the type of antibiotics used after surgery.Methods: We enrolled 240 participants from a teaching hospital in China in which finally enrolled in 221 participants. 106 participants have a history of long-term cigarette use and 115 participants without a history of smoking. All participants received general anesthesia for various surgeries, and rocuronium was used as the muscular relaxant. The primary outcome was the effective onset time of rocuronium after adjusting for its dose. The secondary outcomes included a recovery index and the time of muscle recovery changing from 25 to 75%.Results: There was no measurable difference in the muscle relaxant onset time, duration of effectiveness, 75% recovery, recovery index, dose of opiates, anesthetics during surgery, or complication rate between smokers or non-smokers. However, the results showed a significant difference in antibiotic use between smokers and non-smokers (chi-squared = 13.695, p < 0.001), and a significant difference in the type of antibiotics used (chi-squared = 21.465, p = 0.003). Smokers had a significantly higher rate of cefathiamidine use.Conclusion: Smoking cigarettes had no effect on muscle relaxants used under general anesthesia, but patients who had a history of smoking were more likely to receive antibiotics after surgery.Clinical Trial Registration:http://www.chictr.org.cn/index.aspx, identifier ChiCTR-OIC-16009157.

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Section: Discussionmentioning

confidence: 99%

The Effects of Cigarette Smoking on Steroidal Muscular Relaxants and Antibiotics Used: A Prospective Cohort Study

et al. 2021

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“…Importantly, patients remain conscious throughout and require sedation to relieve anxiety if intubated. Aminoglycosides, clindamycin, and steroids should be avoided as they may worsen muscle atrophy and exacerbate neuromuscular blockade and myopathy (98,99).…”

Section: Botulinummentioning

confidence: 99%

Bioterrorism: Preparing for the impossible or the improbable

Currie

Kvetan

2005

Critical Care Medicine

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There are few instances of a successful large-scale biological weapons attack in history. Weaponization of biological agents for aerosol dispersal is difficult and has often proved to be the rate-limiting step for a successful attack. Although a successful biological attack is currently unlikely, it is still feasible. More importantly, the threat of one is likely to cause much panic in the public, while a successful attack would overburden the current healthcare infrastructure. Intensivists will need to have specific knowledge of identifying and managing casualties from various biological agents. In addition, they will need to play an integral part in the preparedness of their institutions and communities for managing a bioterrorist event.

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“…Penicillin G has been recommended for treatment of wound botulism to reduce the bacterial load and toxin production in the wounds. Aminoglycosides and clindamycin are contraindicated because of their ability to exacerbate neuromuscular blockade [14,29,30].…”

Section: Managementmentioning

confidence: 99%

Botulism: Toxicology, Clinical Presentations and Management

Koirala

2006

Bioterrorism Preparedness

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Clindamycin and nicotinic neuromuscular transmission

Cited by 25 publications

References 3 publications

The Effects of Cigarette Smoking on Steroidal Muscular Relaxants and Antibiotics Used: A Prospective Cohort Study

The Effects of Cigarette Smoking on Steroidal Muscular Relaxants and Antibiotics Used: A Prospective Cohort Study

Bioterrorism: Preparing for the impossible or the improbable

Botulism: Toxicology, Clinical Presentations and Management

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