Clindamycin: An Unusual Cause of Acute Kidney Injury

Abstract

Patient: Male, 52 Final Diagnosis: Clindamycin induced acute kidney injury Symptoms: Nausea • fatigue • anorexia • hematuria • decreased urine output Medication: Clindamycin Clinical Procedure: None Specialty: Nephrology and Internal Medicine Objective: Mistake in diagnosis Background: Medications are one of the most common causes of acute kidney injury (AKI). Elderly patients with diabetes mellitus and chronic kidney disease seem to be at particularly high risk for development of medication-induced AKI. Among antibiotics, the most commonly implicated agents are aminoglycosides, cephalosporins, trimethoprim-sulfamethoxazole, acyclovir, and amphotericin. Despite its widespread use, clindamycin has been rarely associated with AKI. Case Report: A 52-year-old male patient with type II insulin dependent diabetes mellitus without diabetic nephropathy was treated with clindamycin for chronic osteomyelitis. Five days following initiation of therapy, he developed nausea, poor appetite, decrease in urine output, and profound generalized weakness. His symptoms were initially attributed to gastrointestinal side effects of clindamycin and he was advised to take it with food and to hydrate himself vigorously. Despite this change, his symptoms progressed and he developed hematuria and AKI which prompted hospital admission. Extensive workup for AKI that included evaluation for pre-renal, intrinsic renal, and post-renal etiologies failed to point to other etiologies apart from clindamycin-induced AKI. Following cessation of medication and temporary renal replacement therapy (RRT), his renal function returned to baseline. Conclusions: We present a case of clindamycin-induced AKI that was diagnosed after a delay due to uremia symptoms being mistakenly attributed to gastrointestinal side effects of clindamycin. Although rare, clindamycin can be a cause of AKI and clinician should be aware of this association in order to recognize and treat it in timely manner.

The Risk and Clinical Implications of Antibiotic-Associated Acute Kidney Injury: A Review of the Clinical Data for Agents with Signals from the Food and Drug Administration’s Adverse Event Reporting System (FAERS) Database

“…Potential risk factors include gross hematuria, anemia, and hypertension [ 5 ]. One AKI episode within a case series documented the clinical presentation of their patient was quite similar to main adverse effects of clindamycin, specifically nausea, vomiting, and abdominal discomfort [ 5 , 112 ].…”

“…The true AKI incidence for clindamycin is unknown, which likely means the risk of AKI is rare [ 112 ]. The lack of a systematic approach to evaluating AKI risk does not account for the risk of diarrhea and resulting hypovolemia that increase the risk of AKI.…”

Antibacterial Activity of Cold Powder Preparation of (Ethanol Extract) Starfruit Leaf (Averrhoa bilimbi Linn.) Against Propionibacterium acnes

“…Hal ini disebabkan karena klindamisin merupakan antibiotik lincosamide yang terutama bekerja dengan cara mengikat subunit 50 S dapat bersifat bakteriostatik dan bakterisida. Klindamisin menjadi pilihan yang sangat baik untuk pengobatan infeksi (Rusli, 2017;Subedi et al, 2019). Klindamisin memiliki aktivitas yang tinggi terhadap berbagai bakteri fakultatif anaerob.…”