Climbing fibre inputs to cerebellar Purkinje cells from trigeminal cutaneous afferents and the SI face area of the cerebral cortex in the cat.

Miles, Timothy S.; Wiesendanger, M.

doi:10.1113/jphysiol.1975.sp010854

Cited by 59 publications

(19 citation statements)

References 37 publications

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“…It can be concluded that, in trigeminal cutaneous afferents, stimulation of the lowest threshold, fastest-conducting fibres is effective in evoking CF responses in the cerebellar cortex. This is consistent with the finding in the accompanying study (Miles & Wiesendanger, 1975) Relationship of averaged amplitude of CF field potentials in ML, to stimulus intensity. A, the amplitudes of CF field potentials recorded at four different points in the ML, which were evoked at eight levels of intensity of stimulation of the infraorbital branch of the trigeminal nerve.…”

Section: Threshold Of Cf Activationsupporting

confidence: 93%

“…This implies that the CFs which are excited by inputs from the five nerves and SI not only terminate in this area of the cerebellum, but that individual Purkinje cells are probably excited by these six inputs. This was verified in the accompanying study of CF responses in single Purkinje cells (Miles & Wiesendanger, 1975). This convergence must, of course, take place at or before the level of the inferior olive, since, in almost all cases, each Purkinje cell has only one CF synapsing on to it (Eccles, Llinais & Sasaki, 1966).…”

Section: Pattern Of Trigemino-cf Projectionmentioning

confidence: 80%

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Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

Miles¹,

Wiesendanger²

1975

The Journal of Physiology

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SUMMARY1. In cats anaesthetized with pentobarbitone, the projection of climbing fibres (CFs) to the cerebellar cortex from trigeminal cutaneous branches and from the face area of the sensorimotor (SI) cortex was mapped, using the technique of laminar field potential analysis.2. The CF projections from both the trigeminal nerve and the SI face area were found to be localized to the same cerebellar folia, viz. chiefly the ipsilateral lobule HVI, with a small overlap on to the adjacent folia of lobule V and crus Ia of HVIIA. Frequently a projection from the superficial radial nerve to part or all of this area, was also found.3. A correspondence in the distribution and amplitudes of CF potentials evoked at most points by stimulation of the trigeminal nerve and the SI cortex was found. This implies a convergence of afferents from these two sources at or before the inferior olive.4. In more than half of the cats, a small area of the cerebellar hemisphere was found, in which contralateral as well as ipsilateral trigeminal stimulation would evoke CF potentials. Usually inputs from the superficial radial nerve and the SI cortex also converged upon this area.5. The organization of CF projections from trigeminal and superficial radial nerve afferents to the cerebellar hemisphere was found to occur in the same 'patchy' pattern of somatotopy that has been described for spinal nerve inputs to the anterior lobe.6. One constant factor was found in the pattern of organization of CF projections to this area from cutaneous afferent nerves. That is, only the afferents from overlapping areas of skin projected to a given recording point: no instance of CF projections from trigeminal branches innervating discontinuous skin areas was observed.

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Section: Threshold Of Cf Activationsupporting

confidence: 93%

Section: Pattern Of Trigemino-cf Projectionmentioning

confidence: 80%

Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

Miles¹,

Wiesendanger²

1975

The Journal of Physiology

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“…Similar findings have been reported in cats [Hiraoka and Shimamura, 1977;Holstege et al, 1986;Takada et al, 1984;Tamai et al, 1986]. Trigemino-cerebellar climbing fiber afferents are known to be conducted through the inferior olive [Hesslow, 1994;Miles and Wiesendanger, 1975;van Ham and Yeo, 1992] and models of eyeblink conditioning assume the unconditioned stimulus to be passed to the cerebellum via this pathway [Bracha and Bloedel, 1996;Thompson and Krupa, 1994].…”

Section: Brainstem Activationssupporting

confidence: 69%

“…The present findings are essentially consistent with electrophysiological and histological studies showing that the main mossy and climbing fiber input from the face is to ipsilateral lobule H VI. Additional input to lobules H V and H VII and bilateral projections have also been described [Carpenter and Hanna, 1961;Cody and Richardson, 1979;Darian-Smith and Phillips, 1964;Dunn and Matzke, 1968;Hesslow, 1994;Ikeda, 1979;Miles and Wiesendanger, 1975;Snider, 1943;Snider and Stowell, 1944;Somana et al, 1980;Stewart and King, 1963;van Ham and Yeo, 1992].…”

Section: Cerebellar Activationsmentioning

confidence: 92%

Eyeblink‐related areas in human cerebellum as shown by fMRI

Dimitrova

Weber

Maschke

et al. 2002

Human Brain Mapping

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Classical eyeblink conditioning is used frequently to study the role of the cerebellum in associative learning. To understand the mechanisms involved in learning, the neural circuits that generate the eyeblink response should be identified. The goal of the present study was to examine cerebellar regions that are likely to control the human eyeblink response using event-related functional magnetic resonance imaging (fMRI). In 14 healthy volunteers eyeblinks were evoked by unilateral air-puff stimulation (total of 30 stimuli, inter-trial interval 27-44 sec). With eyes closed throughout the experiment, eyeblinks were recorded using a video-based system with infrared reflecting markers being attached to the upper eyelids. From each subject 500 scans were taken (TR = 2.2 sec, 22 slices per scan, slice thickness = 3 mm) using an echo planar imaging sequence (EPI). The statistical parametric maps of the experimental volume images were estimated with SPM99 specifying an appropriate event-related design matrix. Two main regions of significant activation were found in the ipsilateral posterior lobe of the cerebellar hemisphere. In the more anterior region the maxima of activation were located in hemispheral lobules VI and Crus I, and in the more posterior region in hemispheral lobules VIIb, Crus II and VIIIa (nomenclature according to Schmahmann et al. [2000]: MRI Atlas of the Human Cerebellum). Although less pronounced, activity was found also in corresponding areas of the contralateral cerebellar hemisphere. These eyeblink-related areas agree with trigeminal projection areas and blink reflex control areas shown in previous animal studies.

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“…Miles & Wiesendanger, 1975b) or climbing fibre potentials accompanied by either short latency or 'delayed' simple spikes. When present, the latency of the 'early' mossy fibre discharges was similar to that found for extra-ocular muscle inputs (Baker et al 1972), whilst that of climbing fibre responses corresponded to the range (11-26 msec) determined for trigeminal cutaneous unitary discharges by Miles & Wiesendanger (1975 b).…”

Section: Organization Of Trigeminal Projectionsmentioning

confidence: 99%

Mossy and climbing fibre mediated responses evoked in the cerebellar cortex of the cat by trigeminal afferent stimulation.

Cody¹,

Richardson²

1979

The Journal of Physiology

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SUMMARY1. The trigeminal input to the cerebellar cortex was studied by recording mass and unitary responses evoked by electrical stimulation of individual trigeminal cutaneous and muscle nerve branches, in cats lightly anaesthetized with sodium thiopentone.2. The trigeminal projection area of the cerebellar cortex comprised essentially lobule HVI, but included adjacent folia of lobules HV and HVIIA.3. Each trigeminal branch had a 'patchy' representation throughout the projection area and there was extensive convergence of individual afferents at each site. Exact combinations of convergent inputs varied between loci, the projection from the muscle nerve 7. Response patterns comprised one or more of the following: short latency (3-8 msec) simple, mossy fibre-mediated spikes, 'delayed' (10-25 msec) simple spikes and climbing fibre-mediated multiple spike bursts (9-35 msec).

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Climbing fibre inputs to cerebellar Purkinje cells from trigeminal cutaneous afferents and the SI face area of the cerebral cortex in the cat.

Cited by 59 publications

References 37 publications

Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

Eyeblink‐related areas in human cerebellum as shown by fMRI

Mossy and climbing fibre mediated responses evoked in the cerebellar cortex of the cat by trigeminal afferent stimulation.

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