Climbing fibre‐dependent changes in Golgi cell responses to peripheral stimulation

Xu, Wei; Edgley, S A

doi:10.1113/jphysiol.2008.160879

Cited by 39 publications

(44 citation statements)

References 32 publications

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“…In the same vein, recent in vivo work reported that conjunctive stimulation of peripheral afferents and climbing fibers causes depression of GoC firing activity (Xu and Edgley 2008), but the same peripheral stimulation alone does not cause plasticity of activity. The locus of these plastic changes is unclear but is supposed to lie in the inhibitory input from ML interneurons to GoCs.…”

Section: Discussionmentioning

confidence: 97%

Long-Term Depression at Parallel Fiber to Golgi Cell Synapses

Robberechts

Wijnants

Giugliano

et al. 2010

Journal of Neurophysiology

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Golgi cells (GoCs) are the primary inhibitory interneurons of the granular layer of the cerebellum. Their inhibition of granule cells is central to operate the relay of excitatory inputs to the cerebellar cortex. Parallel fibers (PFs) establish synapses to the GoCs in the molecular layer; these synapses contain AMPA, N-methyl-D-aspartate (NMDA), and mostly group II metabotropic glutamate receptors. Long-term changes in the efficacy of synaptic transmission at the PF-GoC synapse have not been described previously. We used whole cell patch-clamp recordings of GoCs in acute rat cerebellar slices to study synaptic plasticity. We report that high-frequency burst stimulation of PFs, using a current-clamp or voltage-clamp induction protocol, gave rise to long-term depression (LTD) at the PF-GoC synapse. This form of LTD was not associated with persistent changes of paired-pulse ratio, suggesting a postsynaptic origin. Furthermore, LTD induction was not dependent on activation of NMDA receptors. PF-GoC LTD does require activation of specifically group II metabotropic glutamate receptors and of protein kinase A.

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Section: Discussionmentioning

confidence: 97%

Long-Term Depression at Parallel Fiber to Golgi Cell Synapses

Robberechts

Wijnants

Giugliano

et al. 2010

Journal of Neurophysiology

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“…The last somatic contact site is lost around this day. Horizontal scale bar: 20 ms anatomical evidence for the formation of synapses on Golgi cells (Hámori and Szentágothai 1966;Chan-Palay and Palay 1971;Sugihara et al 1999), but electrophysiological studies showed inhibition, rather than excitation, of Golgi cells by olivocerebellar axons (Schulman and Bloom 1981;Xu and Edgley 2008). The thick collaterals, the climbing fibers, creep between the multilayered Purkinje cells ("creeper stage") (Chédotal and Sotelo 1993;Morara et al 2001;Sugihara 2005), establishing the first functional synaptic contacts with the postsynaptic Purkinje cells around postnatal day 3 (P3) (Crepel 1971;Woodward et al 1971;Altman 1972).…”

Section: Climbing Fiber Outgrowth and Eliminationmentioning

confidence: 95%

Inferior Olive: All Ins and Outs

Gruijl

Bosman

Zeeuw

et al. 2013

Handbook of the Cerebellum and Cerebellar Disorders

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The inferior olive provides all climbing fibers to the Purkinje cells in the cerebellar cortex and thereby has a strong impact on cerebellar output. As a consequence, the integration of inputs to olivary neurons as well as their intrinsic properties are critical for cerebellar function. In this chapter, all issues that are relevant for their ultimate function are addressed. This chapter starts by reviewing developmental aspects such as the origin and migratory routes of inferior olivary neurons and a description of their axonal outgrowth into climbing fibers innervating Purkinje cells. Subsequently, a detailed description of the olivary subdivisions and the ultrastructure of their neuropil is provided. This is characterized by the presence of dendro-dendritic gap junctions located in glomeruli and by the consistently combined excitatory and inhibitory innervation of their coupled spines. Furthermore, the electrophysiological behavior of olivary neurons is described and discussed. Finally, these unique properties are integrated in cellular and system models. Both type of models show that the inferior olive is very well able to control both rate

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“…In many instances, the long-lasting depressions are not preceded by short-latency spikes and pauses, suggesting that these responses arise from distinct pathways. Interestingly, a pause in Golgi cell discharge, but not excitation, can also be evoked by electrical stimulations of the inferior olive (IO) (Schulman and Bloom 1981;Xu and Edgley 2008). One of the possible explanations is that long-lasting depression is caused by neuromodulation of the Golgi cells themselves or of the other inhibitory interneurons that contact them.…”

Section: Golgi Cells Display a Complex Triphasic Response To Periphermentioning

confidence: 96%

“…34.3f), a short-latency inhibition, and a longlasting inhibition (Fig. 34.3g) Tahon et al 2005;Vos et al 1999b;Xu and Edgley 2008). When stimulating the whiskers or the mystacial pad, short-latency excitation consisted of one or two early spikes (5-10 ms) eventually followed by a later component (13-26 ms), probably of cortical origin Tahon et al 2005; Tahon et al 2011;Vos et al 1999b;Vos et al 2000).…”

Section: Golgi Cells Display a Complex Triphasic Response To Periphermentioning

confidence: 96%

“…Electron-microscopy studies have shown that these collaterals make contacts on large somata and proximal dendrites in the upper GCL, which were originally identified as Golgi cells (Hámori and Szentagothai 1966;Palay and Chan-Palay 1974). However, physiological evidence points to Lugaro cells ( Ekerot and J€ orntell 2003) as the targets of the CFs and the source of disynaptic inhibition onto Golgi cells (Schulman and Bloom 1981;Xu and Edgley 2008).…”

Section: Climbing Fibers Preferentially Target Lugaro Cellsmentioning

confidence: 98%

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Golgi Neurons

Pietrajtis

Dieudonné

2013

Handbook of the Cerebellum and Cerebellar Disorders

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The Golgi cell is an essential cellular component of the cerebellar cortex and the only source of inhibition to the billions of granule cells forming the cortical input layer. While considered as a single neuronal class, separate from Lugaro cells, Golgi cells form a highly heterogeneous population, both morphologically and immunohistochemically. Golgi cells are interconnected by electrical synapses and connected to other cortical cell types by chemical synapses, forming feedforward and feedback inhibitory loops onto granule cells. Golgi cells are thus ideally placed to control the gain and temporal pattern of granule cell discharge in response to afferent mossy fiber activity.In vivo Golgi cells fire irregularly and respond to peripheral stimuli with brief burst responses or prolonged pauses. In the behaving animal, the firing rate of Golgi cells is modulated and forms sensory-motor receptive fields. Furthermore, Golgi cell activity is coordinated with local field potential oscillations in the beta range both locally and along the parallel fiber beams. Detailed computer models have been generated and predict complex oscillatory behaviors of the granule cell layer network at various frequencies. The impact of these oscillations on the encoding capacity of the granular layer is still debated, and further recordings are needed to understand how Golgi cells affect granule cell spike timing.

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Climbing fibre‐dependent changes in Golgi cell responses to peripheral stimulation

Cited by 39 publications

References 32 publications

Long-Term Depression at Parallel Fiber to Golgi Cell Synapses

Long-Term Depression at Parallel Fiber to Golgi Cell Synapses

Inferior Olive: All Ins and Outs

Golgi Neurons

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