Climbing Black Pepper (Piper guineense) Seeds as an Antisickling Remedy

Ameh, Sunday J.; Obodozie, Obiageri O.; Inyang, Uford S.; Abubakar, M.S.; Garba, M.

doi:10.1016/b978-0-12-375688-6.10040-4

Cited by 12 publications

(11 citation statements)

References 14 publications

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“…While the successful application of the WHO model by NIPRD [21][22][23] , had led to the development of Niprisan ®an antisickling phytomedicine, the application of ISO 9001 is widely applauded as the most successful industrial standard in world economic history [24][25][26] . Based on inputs from the departments, the CEO approves a material (eg: aerial parts Mitracarpus scaber) for development as dermal antifungal (coded: AF1).…”

Section: Resultsmentioning

confidence: 99%

Untitled

2012

IJPSR

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Background: Following the Alma-Ata Declaration of 1978, the World Health Organization (WHO) began the issuance of guidelines for developing standardized herbal preparations from Traditional Medicine (TM). Similarly in 1987, the International Organization for Standardization (ISO) launched the most anticipated industrial standard (ISO 9001) in world history. The seventh (7 th ) clause of ISO 9001's eight clauses is devoted to "Product Realization"-a quality management system (QMS) procedure that includes: planning of product realization; appreciation of customer-related processes; design and development processes; purchasing; production and service provision; and control of measuring and monitoring equipment. Purpose: The article takes a hard look at the QMS processes involved in product realization and the critical stages of the WHO model of herbal drug development from TM, with a view to devising a framework that can be used to promote the production of quality herbal products, commencing from the stage of ethnobotanical survey, through the laboratory, to the clinic. Methodology: Both the WHO model of herbal drug development and the 7 th clause of ISO 9001:2008 were critically reviewed and combined to yield a framework that is discussed within the context of guiding herbal drug development from TM. Results and Discussion: The resulting WHO-ISO framework of herbal product realization is discussed in terms of its relevance to practical problems of GMP-production using herbal starting materials, given their innate variability in composition, potency and appearance. Conclusion: The provisions of ISO 9001's seventh clause can, to a large extent, be applied to the production of quality herbal products developed in accordance with WHO.

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Section: Resultsmentioning

confidence: 99%

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2012

IJPSR

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“…As stated earlier [14] E. caryophyllata , P. guineense , P. osun , and S. bicolor are the herbal components of the Yoruba recipe upon which the antisickling drug Niprisan is based. Prior to the era of Niprisan these herbs were either extracted with “ogoro” (ethanolic distillate of palm wine) or with an aqueous solution trona (sodium sesquicarbonate—a mineral used in Nigeria as tenderizer).…”

Section: Introductionmentioning

confidence: 98%

“…In the present we briefly mention these groups of phytochemicals and their synthetic analogues as components of E. caryophyllata and P. guineense, and that they may account for some of the useful effects of Niprisan in sickle cell crisis [14]. …”

Section: Introductionmentioning

confidence: 99%

“…As described elsewhere [ 14 , 16 , 17 ], among the Efik and Ibibio, Hausa, Igbo, Idoma, and Yoruba: clove ( Eugenia caryophyllata or “kanunfari” in Hausa; Piper guineense (“eche” in Idoma or “akwa-ose” in Igbo); grains of paradise ( Aframomum melegueta or “otuta” in Idoma); Sorghum bicolor (the leaf stalk yields an extract that looks like blood); Pterocarpus osun (common in the Yoruba state of Osun) are used in various health conditions, including sickle cell anemia. As stated earlier [ 14 ] E. caryophyllata , P. guineense , P. osun , and S. bicolor are the herbal components of the Yoruba recipe upon which the antisickling drug Niprisan is based. Prior to the era of Niprisan these herbs were either extracted with “ogoro” (ethanolic distillate of palm wine) or with an aqueous solution trona (sodium sesquicarbonate—a mineral used in Nigeria as tenderizer).…”

Section: Introductionmentioning

confidence: 99%

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Traditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria

Ameh

Tarfa

Ebeshi

2012

Anemia

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Background. Patients in West Africa where sickle cell anemia (SCA) is endemic have for ages been treated with natural products, especially herbs, as, is still the case in rural communities. Objective. In this paper we look closely at some of these herbs to see if there are any lessons to be learnt or clues to be found for optimizing the treatments based on them, as had been done in the case of NIPRISAN, which was developed from herbs in Nigeria based on Yoruba Medicine. Methods. Select publications on SCA, its molecular biology and pathology, and actual and experimental cases of herbal treatment were perused in search of molecular clues that can be linked to chemical constituents of the herbs involved. Results. The study revealed that during the last 2-3 decades, much progress was made in several aspects of SCA pharmacology, especially the approval of hydroxyurea. As for SCA herbalism, this paper revealed that antisickling herbs abound in West Africa and that the most promising may yet be found. Three new antisickling herbs (Entandrophragma utile, Chenopodium ambrosioides, and Petiveria alliacea) were reported in May 2011. At NIPRD, where NIPRISAN was developed, three other recipes are currently awaiting development. Conclusion. The study raised the hope that the search in the Tropics for more effective herbal recipes for managing sickle cell anaemia will be more fruitful with time and effort.

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“…For identification, the fruits are prolate and semi-spherical, and retain their curved stalks like tadpoles. Piper guineense has anti-sickling phytochemicals [19]. Monodora myristica is a deciduous ornamental evergreen tree in the rain forest, the trunk can be up to 2 meters in diameter; the leaves are orchid-like; its flowers are scented.…”

Section: Introductionmentioning

confidence: 99%

Terpene-Rich Medicinal Plant Spices for Flavoring of Processed Tropical Food

Obiloma¹,

Madu²,

Osuji³

et al. 2019

AJPS

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Tropical medicinal plant spices have remained underutilized in commercial food processing because of the inadequate chemical characterization of their terpene compositions. The activity of medicinal plants used in flavoring is due to their terpene contents. Terpene contents of Aframomum danielli seeds, Xylopia aethiopica fruits, Syzygium aromaticum leaves, Piper guineense seeds, and Monodora myristica seeds were determined using headspace solid-phase microextraction combined with gas chromatography-mass spectrometry. P. guineense is rich in terpinene and terpinolene (2.5 g per 100 g), S. aromaticum has caryophyllene (0.68 g per 100 g); A. danielli is rich in ocimene (1.65 g per 100 g); X. aethiopica is rich in ocimene (2.94 g per 100 g); M. mystristica is rich in delta carene (0.49 g per 100 g). Combinations of the five medicinal plant spices are being applied as flavorings in packaged tropical food.

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Climbing Black Pepper (Piper guineense) Seeds as an Antisickling Remedy

Cited by 12 publications

References 14 publications

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Traditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria

Terpene-Rich Medicinal Plant Spices for Flavoring of Processed Tropical Food

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