Climate warming increases the proportions of specific antibiotic resistance genes in natural soil ecosystems

Li, Zixin; Sun, Anqi; Liu, Xiaofei; Chen, Qinglin; Bi, Li; Ren, Peixin; Shen, Jin-Hui; Jin, Sheng‐Sheng; He, Ji‐Zheng; Hu, Hang‐Wei; Yang, Yusheng

doi:10.1016/j.jhazmat.2022.128442

Cited by 25 publications

(15 citation statements)

References 41 publications

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“…While our study addresses increases in AMR with warming from an environmental, whole-community perspective, the observed effects were mirrored in resistance profiles of specific pathogens on a clinical level (Li et al, 2022; McGough et al, 2020): Based on an ecological analysis of AMR prevalence in 4Lmillion tested pathogens across 28 European countries between 2000 and 2016, countries with warmer ambient minimum temperatures, experienced more rapid resistance increases ranging from 0.33-1.2% per year across all antibiotic (McGough et al, 2020). Further, in a study across 28 Chinese provinces between 2005 and 2019, a 1°C increase in average ambient temperature was associated with a 6-14% increase in carbapenem resistance in K. pneumoniae and P. aeruginosa (Li et al, 2022). These effects held true, even after accounting for known drivers of resistance such as antibiotic consumption and population density.…”

Section: Discussionmentioning

confidence: 99%

Tradeoffs of increasing temperatures for the spread of antimicrobial resistance in river biofilms

Bagra,

Kneis,

Padfield

et al. 2023

Preprint

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River microbial communities regularly act as the first defense barrier against the spread of antimicrobial resistance genes (ARG) that enter environmental microbiomes through wastewaters. However, how the invasion dynamics of wastewater-born ARGs into river biofilm communities will shift due to increasing average and peak temperatures worldwide through climate change remains unknown. Here we aimed at elucidating the effects of increasing temperatures on both, the natural river biofilm resistome, as well as the river biofilms invadability by foreign, wastewater-born ARGs. To achieve this, natural biofilms were grown in a pristine German river and transferred to artificial laboratory recirculation flume systems at three different temperatures (20°C, 25°C, 30°C). Already after one week of acclimatization to the temperatures, significant increases in the abundance of most naturally occurring ARGs were detected in the biofilms exposed to the highest temperature. Thereafter, biofilms were exposed to a single pulse of wastewater and the invasion dynamics of wastewater-born ARGs were analyzed over a period of two weeks. While initially after one day ARGs were able to invade all biofilms successfully and in equal proportions, the foreign invading ARGs were lost at a far increased rate at 30°C over time. ARG levels dropped to the initial natural levels at 30°C after 14 days. Contrary at the lower temperatures ARGs remained far elevated and certain ARGs were able to establish themselves in the biofilms. Overall, we here demonstrate tradeoffs of increasing temperature between increases in naturally occurring and faster loss dynamics of invading ARGs.

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Section: Discussionmentioning

confidence: 99%

Tradeoffs of increasing temperatures for the spread of antimicrobial resistance in river biofilms

Bagra,

Kneis,

Padfield

et al. 2023

Preprint

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“…Surprisingly, climate effect was more observed in the natural forest ecosystem. They observed increase in 15 ARG genes for common antibiotics such as aminoglycoside, beta-lactam, macrolide-lincosamide-streptogramin B, multidrug, sulphonamide, and tetracycline, enrichment due to the warming treatment [73]. These findings have implications that Global warming due to anthropogenic activities in future can enable evolution of super bugs in the terrestrial ecosystems.…”

Section: Args Can Be Carried By Aerosols and Soilsmentioning

confidence: 99%

Pharmaceuticals and Personal Care Products in the Environment with Emphasis on Horizontal Transfer of Antibiotic Resistance Genes

Prasad

Elchuri

2022

Chemistry-Didactics-Ecology-Metrology

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Pharmaceuticals and personal care products (PPCPs) discharged into environment has several adverse impacts. PPCPs are widely utilised for veterinary as well as cosmetic and personal health reasons. These are members of the expanding class of substances known as Contaminants of Emerging Concern (CECs). Antibiotic resistance in the environment and garbage generated by PPCP endanger life. The World Health Organisation (WHO) now recognises antibiotic resistance as a significant global health problem due to the expected increase in mortality caused by it. In the past ten years, mounting data has led experts to believe that the environment has a significant impact on the development of resistance. For human diseases, the external environment serves as a source of resistance genes. It also serves as a major pathway for the spread of resistant bacteria among various habitats and human populations. Large-scale DNA sequencing methods are employed in this thesis to better comprehend the dangers posed by environmental antibiotic resistance. The quantification of the number is an important step in this process. Metagenomic measurement of the number of antibiotic resistance genes in various contexts is a crucial step in this process. However, it’s also crucial to put this data into a broader context by integrating things like taxonomic information, antibiotic concentrations, and the genomic locations of found resistance genes.

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“…The The climate warming treatment was initiated in 2014, employing a random block design in both the natural forest and plantation forest (Li et al, 2022). In the study area, 10 plots measuring 6 m × 6 m were allocated for the experiment, following a randomised block design.…”

Section: Field Site Description and Soil Samples Collectionmentioning

confidence: 99%

Seasonality regulates the taxonomic and functional compositions of protists responding to climate warming in forest ecosystems

Li,

Sun,

Liu

et al. 2023

J of Sust Agri & Env

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IntroductionProtists are unicellular eukaryotes including important predators, parasites and phototrophs, and play pivotal roles in organic matter decomposition, biogeochemical nutrient cycling and various ecosystem functions. Unravelling the impact of climate warming on soil protists is paramount in predicting how these microorganisms will continue to provide essential ecosystem services in the face of changing climatic conditions.Materials and MethodsWe examined the effects of 5‐year simulated climate warming scenario, with temperatures increased by 4°C above ambient levels, on the diversity and community composition of soil protists, as well as their interactions with other microorganisms in both natural and plantation forest ecosystems during three seasons: summer, autumn and winter.ResultsWe found a season‐dependent response of protists to climate warming, with a significant decrease in protist diversity during winter in natural forests. Furthermore, we identified significant alterations in the community compositions of protists during summer in both natural and plantation forests, as well as during winter in both forest types, under warming. Our analysis pinpointed specific functional protist taxa, such as consumers, parasites and phototrophs, which exhibited significant shifts in their relative abundances under warming. Additionally, we found that warming facilitated trophic interactions between protists and bacteria, while also strengthening interactions between bacterial and fungal communities. Warming could induce direct modifications in protist community compositions or indirectly affect them by modifying bacterial and fungal communities, as revealed by structural equation modelling.ConclusionThese findings demonstrate the substantial impact of warming on the taxonomic and functional compositions of protists in forest ecosystems, with the magnitude of these effects varying across seasons. Our study implicates that ongoing climate warming could have significant consequences for the profiles of soil protists, as well as their trophic interactions with bacteria and fungi, highlighting the importance of considering these effects for the sustainable provision of ecosystem functions.

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Climate warming increases the proportions of specific antibiotic resistance genes in natural soil ecosystems

Cited by 25 publications

References 41 publications

Tradeoffs of increasing temperatures for the spread of antimicrobial resistance in river biofilms

Tradeoffs of increasing temperatures for the spread of antimicrobial resistance in river biofilms

Pharmaceuticals and Personal Care Products in the Environment with Emphasis on Horizontal Transfer of Antibiotic Resistance Genes

Seasonality regulates the taxonomic and functional compositions of protists responding to climate warming in forest ecosystems

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