Climate toxicity: An increasingly relevant clinical issue in Cancer Care

Weadick, Catherine S; Keogh, Rachel J.; Carroll, Hailey; Boldrin, Sandra; Mulroe, Eibhlin; Murphy, Lucy Eldersveld; Sheils, Bryan; Barry, Aisling; O’Reilly, Seamus

doi:10.1016/j.jcpo.2023.100410

Cited by 7 publications

(3 citation statements)

References 53 publications

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“…Interestingly, a bidirectional relationship between climate change and cancer exists. With the term “climate toxicity”, Weadick et al refer to the negative impact of healthcare workers and facilities on the environment, such as carbon production and greenhouse emissions due to both diagnostic and therapeutic interventions [ 46 ].…”

Section: Climate Change In Health and Diseasementioning

confidence: 99%

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

Rio,

Caldarelli,

Gasbarrini

et al. 2024

Diseases

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According to the definition provided by the United Nations, “climate change” describes the persistent alterations in temperatures and weather trends. These alterations may arise naturally, such as fluctuations in the solar cycle. Nonetheless, since the 19th century, human activities have emerged as the primary agent for climate change, primarily attributed to the combustion of fossil fuels such as coal, oil, and gas. Climate change can potentially influence the well-being, agricultural production, housing, safety, and employment opportunities for all individuals. The immune system is an important interface through which global climate change affects human health. Extreme heat, weather events and environmental pollutants could impair both innate and adaptive immune responses, promoting inflammation and genomic instability, and increasing the risk of autoimmune and chronic inflammatory diseases. Moreover, climate change has an impact on both soil and gut microbiome composition, which can further explain changes in human health outcomes. This narrative review aims to explore the influence of climate change on human health and disease, focusing specifically on its effects on the immune system and gut microbiota. Understanding how these factors contribute to the development of physical and mental illness may allow for the design of strategies aimed at reducing the negative impact of climate and pollution on human health.

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Section: Climate Change In Health and Diseasementioning

confidence: 99%

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

Rio,

Caldarelli,

Gasbarrini

et al. 2024

Diseases

View full text Add to dashboard Cite

show abstract

“…Globally this equates to the emissions of the continent of Africa which has 1.5 billion people among 54 countries. Within healthcare, clinical trials have a carbon footprint equivalent to 50% of the annual footprint of Denmark, while the footprint of scienti c discovery has the same annual footprint as Venezuela [5]. Integration of climate smart strategies in the clinical trial arena could mitigate against climate change, and subsequently create and embed a climate responsible ecosystem within clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Climate Change Advocacy and Cancer Clinical Trial Organisations

Myoo,

weadick,

murphy

et al. 2024

Preprint

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Climate change is a threat to human health; equally health care is a threat to climate change as it accounts for 4% of greenhouse gas emissions and 30% of the world’s electronically stored data. 350,000 international trials are registered on ClinicalTrials.gov with ~ 27·5 million tonnes of emissions (equivalent to half of annual Danish emissions). In September 2023 we assessed climate awareness among cancer clinical trial organisations via a web-based scoping exercise. Seventy-five organisations were identified of whom 46 had search tools on their websites. Eight out of 46 clinical trial groups had at least one parameter of commitment to climate change, and 38 organisations had none. Of 46 websites, 5 had climate change position statements or policies, 4 had a committee or task force, 1 provided patient education resources for climate change via video link, 7 included green initiative advice and 8 had publications addressing climate change. Only 5 were listed as members of Climate Change Consortiums. Based on website assessment climate advocacy among cancer clinical trial organisations is low, and efforts to encourage climate engagement are needed.

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“…Whether the environmental cost is sufficiently offset by the clinical and other benefits obtained is an area for further evaluation (e.g. if waste associated with the manufacture, distribution and administration of systemic therapeutics is reduced or avoided [Weadick et al, 2023 ]) and as well as the direct and indirect non-financial costs of these tests.…”

mentioning

confidence: 99%

Editorial on polygenic risk scores: Colloquium held at the Centre for Personalised Medicine, Oxford

Dixon,

Briggs,

Lucassen

2023

Camb. prisms Precis. med.

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Climate toxicity: An increasingly relevant clinical issue in Cancer Care

Cited by 7 publications

References 53 publications

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

Climate Change Advocacy and Cancer Clinical Trial Organisations

Editorial on polygenic risk scores: Colloquium held at the Centre for Personalised Medicine, Oxford

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