Climate change and preterm birth: A narrative review

Bátiz, Luis Federico; Illanes, Sebastián E.; Romero, Roberto; BARRERA, Maria del Valle; MATTAR, Citra N.Z.; Choolani, Mahesh; Kemp, Matthew W.

doi:10.1016/j.envadv.2022.100316

Cited by 4 publications

(2 citation statements)

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“…Increased lead levels have been linked to a number of negative pregnancy outcomes, for instance, gestational hypertension, spontaneous abortion, and low birth weight. [ 5 ] Lead is quickly absorbed via the placenta by passive diffusion, and fetal brain tissue has been discovered as early as the 1 st trimester. Children are particularly susceptible to neurological problems brought on by lead exposure because of their developing brain systems.…”

Section: Introductionmentioning

confidence: 99%

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

Sahu,

Yogeshbhai,

Oza

et al. 2024

Journal of Family Medicine and Primary Care

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Background and Aim: With the growth of the world’s economy and industrialization, lead (Pb) contamination in the environment has become a major issue on a global scale. Lead is typically linked to unfavorable pregnancy outcomes such as stillbirth, low birth weight preterm, and spontaneous abortion. In this study, we evaluated the blood lead levels of pregnant women and their birth outcomes attending an Indian tertiary care teaching hospital, those who were not exposed to any lead-associated industry or shops. Methods: A descriptive study was undertaken to evaluate blood lead estimation in pregnant women and umbilical blood lead levels in a community hospital. Blood samples from 104 mothers during the 1st trimester, 90 mothers during 3rd trimester, and from the umbilical cord were collected. Self-administered questionnaires were used to collect information on demographics, medical history, and concerns linked to pregnancy. Following acid digestion, the levels of lead in whole blood were determined by an atomic absorption spectrometer. The DNA damage in high blood lead-concentrated pregnant women was evaluated by comet assay methods. Results: Among 194 blood samples of pregnant women, 31 (15.98%) samples revealed ≥5 μg/dL blood lead levels. High lead concentration (≥5 µg/dL) in 1st trimester pregnant women, end of 3rd trimester and cord blood were detected 20.19%, 11.11% and 1.11% respectively. The mean blood lead levels in 1st trimester, 3rd trimester, and cord blood were 3.88 ± 3.19, 2.66 ± 1.82, and 1.53 ± 1.06 mg/dL, respectively. The blood lead concentrations were significantly higher in the 1st trimester of pregnancy than in the 3rd trimester of pregnancy (P < 0.0017). A positive correlation between maternal and infant blood lead levels was revealed (P < 0.0001). When the comet assay was used to assess the genotoxic consequences of elevated blood lead levels during pregnancy, higher amounts of DNA damage were found in the samples (P < 0.01). Conclusion: In this descriptive study, there was a significant amount of lead transferred from mother to baby through the placenta. All mothers were not exposed to lead-associated industry and most were housewives. This article may be viewed as an eye-opener for understanding the blood lead concentration during pregnancy to avoid abnormal birth outcomes. To minimize exposure to environmental lead, all possible measures should be undertaken.

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Section: Introductionmentioning

confidence: 99%

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

Sahu,

Yogeshbhai,

Oza

et al. 2024

Journal of Family Medicine and Primary Care

View full text Add to dashboard Cite

show abstract

“…7 Específicamente, para las mujeres embarazadas las olas de calor se asocian aparto pretérmino, nacimiento antes de las 37 semanas de gestación, lo cual puede generar consecuencias adversas como: problemas respiratorios y retraso en el crecimiento y neurodesarrollo de los recién nacidos. 8 Se han identificado y explicado las relaciones entre aumento de temperatura y el parto prematuro; se encontró que el aumento de la temperatura en 1 grado centígrado (1 o C) aumentaba las probabilidades de parto pretérmino en un 5% y la exposición a las olas de calor incrementaba las probabilidades de riesgo de parto pretérmino en un 16%. 3 Fisiológicamente, se conoce que la exposición al calor puede provocar: (1) el inicio prematuro del trabajo de parto por deshidratación (a través de la liberación de prostaglandinas u oxitocina), por cambios en la viscosidad de la sangre, y la termorregulación ineficiente puede desencadenar la ruptura prematura de membranas.…”

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