Climate change and neurodegenerative diseases

Bongioanni, Paolo; Carratore, R. Del; Corbianco, Silvia; Diana, Andrea; Masciandaro, Silvia Maria; Dini, Marco; Buizza, Roberto

doi:10.1016/j.envres.2021.111511

Cited by 60 publications

(32 citation statements)

References 128 publications

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“…A growing number of studies in recent years have shown that many human health problems, including ocular surface diseases, may be adversely affected by changes in weather patterns, especially extreme meteorological factors (Lu et al 2019 ). The effects of weather factors on neurodegenerative pathologies (Bongioanni et al 2021 ), cardiovascular system diseases (Khraishah et al 2022 ), and some infectious diseases (Williams et al 2021 ) have been extensively studied, but there are still fewer studies on the effects of direct exposure to the environment on ocular surface diseases. In a nationwide, population‐based, cross‐sectional study, Lee et al found that patients with allergic conjunctivitis had increased incidence in May (spring), September (autumn), and the valley in winter (Lee et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of meteorological factors and extreme weather on daily outpatient visits for conjunctivitis from 2013 to 2020: a time-series study in Urumqi, China

Gui

Qiao

Wang

et al. 2023

Environ Sci Pollut Res

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Conjunctivitis is a common multifactorial inflammatory ocular surface disease characterized by symptoms such as congestion, edema, and increased secretion of conjunctival tissue, and the potential effects of meteorological factors as well as extreme meteorological factors on conjunctivitis and their lagging effects have not been fully evaluated. We obtained the electronic case information of 59,731 outpatients with conjunctivitis from the Ophthalmology Department of the First Affiliated Hospital of Xinjiang Medical University (Urumqi, Xinjiang, China) for the period from January 1, 2013, to December 31, 2020. Meteorological data for daily mean temperature (°C), daily relative humidity (%), daily average wind speed (m/s), and atmospheric pressure (hPa) were obtained from the China Meteorological Data Sharing Service. The air pollutant data were obtained from 11 standard urban background fixed air quality monitors. A time-series analysis design and a quasi-Poisson generalized linear regression model combined with a distributed lagged nonlinear model (DLNM) were used to fit the effects of exposure to different meteorological factors and extreme weather on conjunctivitis outpatient visits. Subgroup analyses were performed on gender, age and season, and type of conjunctivitis. Univariate and multifactorial model results indicated that each 10-unit increase in mean temperature and relative humidity was associated with an increased risk of conjunctivitis outpatient visits, while each 10-unit increase in atmospheric pressure was associated with a decreased risk. The results of the extreme weather analysis suggested that extremely low levels of atmospheric pressure and relative humidity as well as extreme levels of temperature were associated with an increased risk of outpatient conjunctivitis visits, and extreme wind speeds were associated with a decreased risk. The results of the subgroup analysis suggested gender, age, and seasonal differences. We conducted the first large sample size time-series analysis in the large city furthest from the ocean in the world and confirmed for the first time that elevated mean temperature and extreme low levels of relative humidity in Urumqi were risk factors for local conjunctivitis outpatient visits, while elevated atmospheric pressure and extreme low levels of wind speed were protective factors, and there were lagged effects of temperature and atmospheric pressure. Multicenter studies with larger sample sizes are needed. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-023-26335-4.

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Section: Discussionmentioning

confidence: 99%

Long-term effects of meteorological factors and extreme weather on daily outpatient visits for conjunctivitis from 2013 to 2020: a time-series study in Urumqi, China

Gui

Qiao

Wang

et al. 2023

Environ Sci Pollut Res

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“…From our ndings, it appears that chronic exposure to higher temperatures in environments that are already warmer than others correlate with the onset of neurodegenerative events of clinical relevance. It can be hypothesized that populations already exposed to higher temperatures have a thermoregulation system more prone to develop neuroin ammatory events (Bongioanni et al, 2021). A plethora of both molecular and metabolic features related to organ homeostasis (e.g., hypothalamus control, hormonal networks, heat shock proteins) is activated in living endothermic organisms that can compensate for temperature changes.…”

Section: Discussionmentioning

confidence: 99%

“…causing, if prolonged, the activation of biochemical pathways (such as oxidative stress and excitotoxicity) ultimately linked to neurodegeneration(Zammit et al, 2021). The main molecular pathways altered by temperature, affecting neuronal health and potentially causing the onset of neurodegenerative diseases(Lee et al, 2015;Chauhan et al, 2017), have been reported and discussed in a recent review byBongioanni et al (2021). All effects are ampli ed particularly in elderly people, whose thermoregulation is compromised.…”

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confidence: 99%

Evidence of Climate Change Impact on Parkinson’s Disease

Buizza

Carratore

Bongioanni

2021

Preprint

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We have investigated the link between climate change and Parkinson’s diseases (PD) by contrasting variations between 1990 and 2016 of PD patients’ indices (prevalence, deaths, and disability-adjusted life years) and climate indices (warming and annual average temperature) for 185 countries. Countries have been clustered in four categories, depending on whether they had higher-than-median warming and higher-than-median temperature, and for each cluster variations in PD patients’ and climate indices have been studied. In the cluster of the 25 countries (home to about 900 million people) characterized by higher-than-average warming and higher-than-average temperature, we have found evidence of a correlation between more intense warming and higher variations. This statistical result is discussed and linked to other evidence reported in literature. To our knowledge, this is the first time that a statistically-sound link between climate change and the epidemiological data of PD patients has been found and documented.

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“…We have recently reviewed scientific works that discuss the impact of climate change induced by global warming and in particular the increased frequency and intensity of heat waves, on health problems. Global warming can significantly increase the rate of neurodegenerative disorders by inducing persistent heat stress even at temperature ranges that, acutely, would be tolerable for neurons [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Global Warming on Patients with Dementia, Motor Neuron or Parkinson’s Diseases: A Comparison among Cortical and Subcortical Disorders

Bongioanni

Carratore

Dolciotti

et al. 2022

IJERPH

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Exposure to global warming can be dangerous for health and can lead to an increase in the prevalence of neurological diseases worldwide. Such an effect is more evident in populations that are less prepared to cope with enhanced environmental temperatures. In this work, we extend our previous research on the link between climate change and Parkinson’s disease (PD) to also include Alzheimer’s Disease and other Dementias (AD/D) and Amyotrophic Lateral Sclerosis/Motor Neuron Diseases (ALS/MND). One hundred and eighty-four world countries were clustered into four groups according to their climate indices (warming and annual average temperature). Variations between 1990 and 2016 in the diseases’ indices (prevalence, deaths, and disability-adjusted life years) and climate indices for the four clusters were analyzed. Unlike our previous work on PD, we did not find any significant correlation between warming and epidemiological indices for AD/D and ALS/MND patients. A significantly lower increment in prevalence in countries with higher temperatures was found for ALS/MND patients. It can be argued that the discordant findings between AD/D or ALS/MND and PD might be related to the different features of the neuronal types involved and the pathophysiology of thermoregulation. The neurons of AD/D and ALS/MND patients are less vulnerable to heat-related degeneration effects than PD patients. PD patients’ substantia nigra pars compacta (SNpc), which are constitutively frailer due to their morphology and function, fall down under an overwhelming oxidative stress caused by climate warming.

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Climate change and neurodegenerative diseases

Cited by 60 publications

References 128 publications

Long-term effects of meteorological factors and extreme weather on daily outpatient visits for conjunctivitis from 2013 to 2020: a time-series study in Urumqi, China

Long-term effects of meteorological factors and extreme weather on daily outpatient visits for conjunctivitis from 2013 to 2020: a time-series study in Urumqi, China

Evidence of Climate Change Impact on Parkinson’s Disease

Effects of Global Warming on Patients with Dementia, Motor Neuron or Parkinson’s Diseases: A Comparison among Cortical and Subcortical Disorders

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