Climate and Urbanization Drive Mosquito Preference for Humans

Rose, Noah H.; Sylla, Massamba; Badolo, Athanase; Lutomiah, Joel; Ayala, Diégo; Aribodor, Ogechukwu B.; Ibe, Nnenna; Akorli, Jewelna; Otoo, Sampson; Mutebi, John Paul; Kriete, Alexis L.; Ewing, Eliza G.; Sang, Rosemary; Gloria‐Soria, Andrea; Powell, Jeffrey R.; Baker, Richard F.; White, Bradley J.; Crawford, Jacob E.; McBride, Carolyn S.

doi:10.1016/j.cub.2020.06.092

Cited by 172 publications

(303 citation statements)

References 46 publications

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“…Although evidence of adaptive shifts in mosquito preference towards certain genotypes of the same host species is still lacking, drastic changes in human population density across Africa has likely facilitated the specialization of Ae. aegypti in biting humans over other animals [114].…”

Section: Evolutionary Ecology Of Vector Biting Amentioning

confidence: 99%

Differential attraction in mosquito–human interactions and implications for disease control

Martinez

Showering

Oke

et al. 2020

Phil. Trans. R. Soc. B

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Mosquito-borne diseases are a major burden on human health worldwide and their eradication through vector control methods remains challenging. In particular, the success of vector control interventions for targeting diseases such as malaria is under threat, in part due to the evolution of insecticide resistance, while for other diseases effective control solutions are still lacking. The rate at which mosquitoes encounter and bite humans is a key determinant of their capacity for disease transmission. Future progress is strongly reliant on improving our understanding of the mechanisms leading to a mosquito bite. Here, we review the biological factors known to influence the attractiveness of mosquitoes to humans, such as body odour, the skin microbiome, genetics and infection by parasites. We identify the knowledge gaps around the relative contribution of each factor, and the potential links between them, as well as the role of natural selection in shaping vector–host–parasite interactions. Finally, we argue that addressing these questions will contribute to improving current tools and the development of novel interventions for the future. This article is part of the theme issue ‘Novel control strategies for mosquito-borne diseases'.

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Section: Evolutionary Ecology Of Vector Biting Amentioning

confidence: 99%

Differential attraction in mosquito–human interactions and implications for disease control

Martinez

Showering

Oke

et al. 2020

Phil. Trans. R. Soc. B

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“…This is particularly evident in arthropod vectors that transmit various life-threatening diseases [15][16][17]. For example, multiple anopheline species altered their behavioral repertoire following sustained use of bed nets and indoor spraying [18]; ancestral African aedenine populations evolved to be human commensals facilitated by behavioral and genetic changes [19,20] such as house-entering behavior [21], and enhanced human preference [19] facilitated by chemoreceptor gene families [19,22,23]. Since the communication system-comprising songs and pheromones-is well defined in the L. longipalpis complex, we undertook a study to explore the genetic basis of the pheromone communication component.…”

Section: Introductionmentioning

confidence: 99%

Molecular signatures of sexual communication in the phlebotomine sand flies

et al. 2020

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Phlebotomine sand flies employ an elaborate system of pheromone communication wherein males produce pheromones that attract other males to leks (thus acting as an aggregation pheromone) and females to the lekking males (sex pheromone). In addition, the type of pheromone produced varies among populations. Despite the numerous studies on sand fly chemical communication, little is known of their chemosensory genome. Chemoreceptors interact with chemicals in an organism’s environment to elicit essential behaviors such as the identification of suitable mates and food sources. Thus, they play important roles during adaptation and speciation. Major chemoreceptor gene families, odorant receptors (ORs), gustatory receptors (GRs) and ionotropic receptors (IRs) together detect and discriminate the chemical landscape. Here, we annotated the chemoreceptor repertoire in the genomes of Lutzomyia longipalpis and Phlebotomus papatasi, major phlebotomine vectors in the New World and Old World, respectively. Comparison with other sequenced Diptera revealed a large and unique expansion where over 80% of the ~140 ORs belong to a single, taxonomically restricted clade. We next conducted a comprehensive analysis of the chemoreceptors in 63 L. longipalpis individuals from four different locations in Brazil representing allopatric and sympatric populations and three sex-aggregation pheromone types (chemotypes). Population structure based on single nucleotide polymorphisms (SNPs) and gene copy number in the chemoreceptors corresponded with their putative chemotypes, and corroborate previous studies that identified multiple populations. Our work provides genomic insights into the underlying behavioral evolution of sexual communication in the L. longipalpis species complex in Brazil, and highlights the importance of accounting for the ongoing speciation in central and South American Lutzomyia that could have important implications for vectorial capacity.

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“…This is particularly evident in arthropod vectors that transmit various life-threatening diseases [15][16][17]. For example, multiple anopheline species altered their behavioral repertoire following sustained use of bed nets and indoor spraying [18]; ancestral African aedenine populations evolved to be human commensals facilitated by behavioral and genetic changes [19,20] such as house-entering behavior [21], and enhanced human preference [19] facilitated by chemoreceptor gene families [19,22,23]. Since the communication system -comprising songs and pheromones --is well defined in sand fly species complex, we undertook a study to isolate and identify the genetic basis of such behaviors.…”

Section: Introductionmentioning

confidence: 99%

Molecular signatures of sexual communication in the phlebotomine sand flies

Hickner

Timoshevskaya

Nowling³

et al. 2020

Preprint

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Phlebotomine sand flies employ an elaborate system of pheromone communication wherein males produce pheromones that attracts other males to leks (thus acting as aggregation pheromone) and females to the lekking males (sex pheromone). In addition, the type of pheromone produced varies among populations. Despite the numerous studies on sand fly chemical communication, little is known of their chemosensory genome. Chemoreceptors interact with chemicals in an organism’s environment to elicit essential behaviors such as the identification of suitable mates and food sources, thus, they play important roles during adaptation and speciation. Major chemoreceptor gene families, odorant receptors (ORs), gustatory receptors (GRs) and ionotropic receptors (IRs) together detect and discriminate the chemical landscape. Here, we annotated the chemoreceptor repertoire in the genomes of Lutzomyia longipalpis and Phlebotomus papatasi, major phlebotomine vectors in the New World and Old World, respectively. Comparison with other sequenced Diptera revealed a large and unique expansion where over 80% of the ~140 ORs belong to a single, taxonomically restricted clade. We next conducted comprehensive analysis of the chemoreceptors in 63 Lu. longipalpis individuals from four different locations in Brazil representing allopatric and sympatric populations and three aggregation-sex pheromone types (chemotypes). Population structure based on single nucleotide polymorphisms (SNPs) and gene copy number in the chemoreceptors corresponded with their putative chemotypes, and corroborate previous studies that identified multiple populations. Our work provides genomic insights into the underlying behavioral evolution of sexual communication in the L. longipalpis species complex in Brazil, and highlights the importance of accounting for the ongoing speciation in central and South American Lutzomyia that could have important implications for vectorial capacity.

show abstract

Climate and Urbanization Drive Mosquito Preference for Humans

Cited by 172 publications

References 46 publications

Differential attraction in mosquito–human interactions and implications for disease control

Differential attraction in mosquito–human interactions and implications for disease control

Molecular signatures of sexual communication in the phlebotomine sand flies

Molecular signatures of sexual communication in the phlebotomine sand flies

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