2022
DOI: 10.4254/wjh.v14.i12.2025
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CLIF-SOFA and CLIF-C scores for the prognostication of acute-on-chronic liver failure and acute decompensation of cirrhosis: A systematic review

Abstract: BACKGROUND Acute-on-chronic liver failure (ACLF) is a syndrome characterized by decompensation in individuals with chronic liver disease, generally secondary to one or more extra-hepatic organ failures, implying an elevated mortality rate. Acute decompensation (AD) is the term used for one or more significant consequences of liver disease in a short time and is the most common reason for hospital admission in cirrhotic patients. The European Association for the Study of Liver-Chronic-Liver Failure… Show more

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Cited by 9 publications
(2 citation statements)
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“…This has been demonstrated in a few previous retrospective cohorts[ 73 , 77 - 81 ]. A recent systematic review investigated the ability of the CLIF-SOFA, CLIF-C ACLF, and CLIF-C AD scores for prognosticating acute-on-chronic liver failure and acute decompensation of cirrhosis and it was found that these scores are accurate as short-term and long-term mortality prognosticating scores, with CLIF-SOFA being the most effective in predicting mortality in ACLF patients, especially in the short-term[ 82 ].…”
Section: Discussionmentioning
confidence: 99%
“…This has been demonstrated in a few previous retrospective cohorts[ 73 , 77 - 81 ]. A recent systematic review investigated the ability of the CLIF-SOFA, CLIF-C ACLF, and CLIF-C AD scores for prognosticating acute-on-chronic liver failure and acute decompensation of cirrhosis and it was found that these scores are accurate as short-term and long-term mortality prognosticating scores, with CLIF-SOFA being the most effective in predicting mortality in ACLF patients, especially in the short-term[ 82 ].…”
Section: Discussionmentioning
confidence: 99%
“…All these scores have good performance in ACLF prognosis assessment and disease severity, but the effect of early warning and accurate assessment of ACLF for patients with various acute and chronic liver diseases was unsatisfactory. [8][9][10][11][12] In a retrospective study of 75,922 patients with compensatory cirrhosis, Karen Y. et al 13 used multivariate logistic regression to develop predictive models (called voice-Penn) for the occurrence of ACLF at 3, 6, and 12 months. They found that albumin(ALB), international normalized ratio(INR), total bilirubin(TBiL), and creatinine(Cr) were signi cant predictors at each time point.…”
Section: Introductionmentioning
confidence: 99%