Click Synthesis of Novel 3‐(2‐(2,4,5‐Triphenyl‐1H‐imidazol‐1‐yl)ethyl)‐1H‐indoles Catalyzed by Glacial Acetic Acid and their Antibacterial Evaluation

Abstract

In this communication, we wish to report a click, simple and efficient one‐pot four component synthesis of a new series of 3‐(2‐(2,4,5‐triphenyl‐1H‐imidazol‐1‐yl)ethyl)‐1H‐indoles using catalytic quantity of acetic acid. The synthesized compounds were evaluated for their in‐vitro antibacterial activity against gram‐positive (Staphylococcus aureus) and gram‐negative (Escherichia coli) bacteria. Tetracycline was used as standard in this antibacterial investigation. The present protocol has several advantages such as excellent yields, very shorter reaction time, operational simplicity, mild reaction conditions, easy work up, inexpensive, easily available catalyst and starting materials, a cleaner reaction media and no need for any chromatographic separation techniques. The synthesized compounds were characterized by 1H, 13C‐NMR and ESI‐MS analyses.