“Click” preparation of a chiral macrocycle-based stationary phase for both normal-phase and reversed-phase high performance liquid chromatography enantioseparation

Recent progress for chiral stationary phases based on chiral porous materials in high‐performance liquid chromatography and gas chromatography separation

“…In addition to the use of chiral PCMs (MOFs, COFs, MOCs, and POCs) as chromatographic CSPs. Other chiral porous materials include homochiral metallacycle [129], CPM [130,131], chiral porous organic polymers [132], chiral covalent triazine frameworks [133,134], chiral multi-shelled mesoporous carbon nanospheres [135], chiral hydrogen-bonded organic frameworks [136] are also being developed as CSPs for chromatographic chiral separations and showed good separation performance for many racemates. With the continuous research of new chiral porous materials, we believe that it will have good potential for practical application as an emerging CSP.…”

A C4-modified bipyridinium multi-mode stationary phase for reversed phase, hydrophilic interaction and ion exchange chromatography

“…Nowadays, the stationary phases based on a single retention mechanism are well developed and applied. RPLC can be used to effectively separate organic compounds, 6–10 HILIC is mainly used for the separation of polar analytes, 11–13 and IEC is usually used for separating ionic compounds by ion exchange mechanism. 14 However, with the development of analytical chemistry in the fields of the environment, pharmacometabonomics, food and biotechnology, chromatographic stationary phases with a single retention mechanism cannot enable the separation and analysis of highly mixed analytes comprising polar, non-polar and ionic compounds.…”