Click chemistry: a transformative technology in nuclear medicine

Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

“…32,33 It is worth noting that click chemistry has a wide application in medicinal chemistry. 34–37 The structure–activity relationship (SAR) studies showed that the 3-chloro and 4-methyl substituents in the coumarin moiety exhibited greater activity, whereas the 3-ethoxycarbonyl group in the coumarin ring exhibited reduced effectivity. It was also found that all these hybrids exhibited greater activity against the HT-29 cancer cell line under anoxic conditions.…”

Functional silicone oils and elastomers: new routes lead to new properties

“…The seminal work of Bertozzi and others to develop catalyst-free alternatives has opened up this field. 50,51 An older alternative Click process, analogous to the Diels-Alder reaction, that also utilizes azides, is the Huisgen cyclization, an uncatalyzed 3+2 cycloaddition that generates both regioisomers and requires about 90 1C to proceed; 52 the need for heating makes it similarly inappropriate for biological systems.…”

Click Chemistry and Radiochemistry: An Update

“…Along these lines, radiopharmaceutical chemistry is a standout example, as the exigencies of radiochemistry align remarkably well with the advantages of click chemistry. 9,10 Indeed, a list of the things that radiochemists need for the effective synthesis of radiopharmaceuticals�simplicity, selectivity, reliability, efficiency, rapidity, and biocompatibility�reads remarkably like a description of the fundamental benefits of click chemistry. In 2006, a team from ETH Zurich led by Mindt create coordination scaffolds for 99m Tc.…”

“…And while it is difficult to find a discipline that has not been touched by click chemistry, some have inevitably been influenced more than others. Along these lines, radiopharmaceutical chemistry is a standout example, as the exigencies of radiochemistry align remarkably well with the advantages of click chemistry. , Indeed, a list of the things that radiochemists need for the effective synthesis of radiopharmaceuticalssimplicity, selectivity, reliability, efficiency, rapidity, and biocompatibilityreads remarkably like a description of the fundamental benefits of click chemistry. In 2006, a team from ETH Zurich led by Mindt and Schibli became the first to harness click chemistry in service of radiochemistry, reporting on the use of the CuAAC ligation to create coordination scaffolds for 99m Tc .…”