Click-based injectable bioactive PEG-hydrogels guide rapid craniomaxillofacial bone regeneration by the spatiotemporal delivery of rhBMP-2

Abstract

The craniomaxillofacial bone defects result in physical and psychological dual injuries make the promotion or acceleration of bone regeneration imperative. In this work, a fully biodegradable hydrogel is facilely prepared...

Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

“…The team of Lao et al created a PEG-based injectable hydrogel, which was immobilized by recombinant human bone morphogenic protein-2 (rhBMP-2) and loaded with rat bone marrow mesenchymal stem cells (rBMSCs). 172 This hydrogel exhibited potent regenerative capacity in the repair of bone defect due to the synergetic effect of the spatiotemporally controlled release of rhBMP-2 and rBMSCs.…”

Smart responsive in situ hydrogel systems applied in bone tissue engineering

“…In addition, countless biomaterials (e.g., collagen, HA, alginate, dextran, chitosan, gelatin, silk, etc.) are modified by chemical bonds to achieve in situ click chemical crosslinking in physical conditions ( Lao et al, 2023 ; Morrison and Gramlich, 2023 ; Rizwan et al, 2023 ; Tournier et al, 2023 ). For example, to prolong the degradation time of HA in vivo , Park et al (2020) .…”

Fabrication of 3D printed PCL/PEG artificial bile ducts as supportive scaffolds to promote regeneration of extrahepatic bile ducts in a canine biliary defect model

“…[27][28][29][30] PEG has been used to mimic the physical properties of the extracellular matrix (ECM). 31,32 The preparation of PEG/PCL composite scaffolds and their applications in biomedicine have been reported in previous studies. [33][34][35][36] In vivo experiments are necessary to gain a comprehensive understanding of the complex process of extrahepatic bile duct regeneration and to establish methodologies for constructing artificial bile ducts.…”

“…27–30 PEG has been used to mimic the physical properties of the extracellular matrix (ECM). 31,32 The preparation of PEG/PCL composite scaffolds and their applications in biomedicine have been reported in previous studies. 33–36…”