Cleistanthoside b a diphyllin glycoside from cleistanthus patulus heartwood

Chemical constituents of the plants of the genus Cleistanthus and their biological activity

“…Diphyllin (1) was isolated from leaves and heartwood of C. collinus (Govindachari et al 1969;Anjaneyulu et al 1981), and from the heartwood of C. patulus (Sastry and Rao 1983;Sastry et al 1987) while collinusin (2) and cleistanone (3) were reported as constituents of leaves and aerial part of C. collinus, respectively (Govindachari et al 1969;Ramesh et al 2003). Several glycosides of diphyllin have been isolated and all of which have the sugar moiety on C-4 of diphyllin.…”

“…Arg. (Sastry and Rao 1983;Sastry et al 1987) and C. schlechteri var. schlechteri from South Africa (McGarry et al 1969;Candy et al 1970) have also been investigated for their constituents.…”

Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

“…A comparison of the antiviral action (119, 773,840) and the cytotoxicity (119, 773,789,800,806,838,[841][842][843] of dehydropodophyllotoxins (315, 316; Fig. 69), justicidins A-E (330, 328, 318, 319, 320), diphyllin (329), retrochinensin (321), retrojusticidin B (322), taiwanin C (337), and some diphyllin-4-0-glycosides (e.g.…”

Cytotoxic Aryltetralin Lignans from Fruits of Cleistanthus indochinensis

“…Cleistanthus is a plant genus of the Euphorbiaceae family and comprises approximately 140 species that are distributed across a variety of locations from Africa to the Pacific Islands [1]. Many plants of this genus are known for their toxic properties [2][3][4][5][6]. Cleistanthus has been shown to contain bioactive lignan compounds such as cleistanthins A and B (from Cleistanthus collinus); these were found to be cytotoxic against several tumor cell lines [7,8].…”

“…fetal bovine serum 6.37 (H-6′). Also, signals of a sugar moiety, two methylenedioxy groups, a methylene, and three methines were noted in the aliphatic region.…”