Cleft lip as a presentation of congenital syphilis

Gupta, Richa; Chotaliya, Kiran; Marfatia, Yogesh S

doi:10.4103/0253-7184.93831

Cited by 5 publications

(1 citation statement)

References 2 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[9] We are also stressing the importance of routine and partner screening to identify the missing out cases and to give the appropriate treatment. [10]…”

mentioning

confidence: 99%

Untreated late latent syphilis of both spouses with observation of Kassowitz Law: Adverse pregnancy outcomes in the postpenicillin Era

Dhanaselvi

Kalaivani

2017

Indian J Dermatol

View full text Add to dashboard Cite

“…[9] We are also stressing the importance of routine and partner screening to identify the missing out cases and to give the appropriate treatment. [10]…”

mentioning

confidence: 99%

Untreated late latent syphilis of both spouses with observation of Kassowitz Law: Adverse pregnancy outcomes in the postpenicillin Era

Dhanaselvi

Kalaivani

2017

Indian J Dermatol

View full text Add to dashboard Cite

Environmental mechanisms of orofacial clefts

Garland

Reynolds

Zhou

2020

Birth Defects Research

View full text Add to dashboard Cite

Orofacial clefts (OFCs) are among the most common birth defects and impart a significant burden on afflicted individuals and their families. It is increasingly understood that many nonsyndromic OFCs are a consequence of extrinsic factors, genetic susceptibilities, and interactions of the two. Therefore, understanding the environmental mechanisms of OFCs is important in the prevention of future cases. This review examines the molecular mechanisms associated with environmental factors that either protect against or increase the risk of OFCs. We focus on essential metabolic pathways, environmental signaling mechanisms, detoxification pathways, behavioral risk factors, and biological hazards that may disrupt orofacial development.

show abstract

Cleft Lip Case in a Middle Bronze Age Young Man from Altai, Russia

Tur

Svyatko

Нечвалода

2016

Int. J. Osteoarchaeol.

View full text Add to dashboard Cite

Oral cleft (OC) is a common congenital anomaly in humans, which occurs in approximately one per 700 live births. However, cleft skulls are found relatively seldom in archaeological specimens, especially for the BC period. Mortality of infants with OC was apparently high because of breastfeeding difficulties and culturally sanctioned rejection of them in the past. This paper presents one of the most ancient cases of OC in Eurasia. The finding comes from the Middle Bronze Age pastoralists' cemetery in Altai, Russia. The skeletal remains have been radiocarbon dated to 1883-1665 cal BC. Cranial and dental measurements, computed tomography and radiography have been used to examine this malformation. The facial sculpting reconstruction has been performed to visualise the ante mortem appearance of the cleft face. Besides, δ 13 C and δ 15 N isotope analysis was used for a comparative study of the diet of the cleft individual. It has been established that a young man from Altai was affected by complete bilateral cleft lip and alveolus, which is a very rare form of typical OC. This defect is associated with dental anomalies such as hypodontia, microdontia, and ectopia as well as with dysmorphology of the facial complex outside the cleft area, including mild hypertelorism, hypoplasia of nasal bones and antheroposterior maxillary deficiency. Furthermore, aplasia of the frontal sinuses and the sacral spina bifida occulta have been observed. These findings are consistent with clinical data indicating strong correlation between development of a major defect and multiple minor anomalies. The results of the study also suggest that there was tolerant attitude towards the facial deformities among the ancient Altai pastoralists.

show abstract

Cleft lip as a presentation of congenital syphilis

Abstract: Congenital syphilis may present with unusual symptoms in early stages which needs to be identified for prompt treatment. Here, we present a case of 13-day-old female child with congenital syphilis presenting with cleft lip.

Cited by 5 publications

References 2 publications

Untreated late latent syphilis of both spouses with observation of Kassowitz Law: Adverse pregnancy outcomes in the postpenicillin Era

Untreated late latent syphilis of both spouses with observation of Kassowitz Law: Adverse pregnancy outcomes in the postpenicillin Era

Environmental mechanisms of orofacial clefts

Cleft Lip Case in a Middle Bronze Age Young Man from Altai, Russia

Contact Info

Product

Resources

About