Cleft and craniofacial surgery – how do we inspire and recruit the next generation of oral and maxillofacial surgeons?

Fullarton, Marnie; Sweet, Chris; Robertson, Ben; Begley, Anne; Magennis, Patrick

doi:10.1016/j.bjoms.2019.01.020

British Journal of Oral and Maxillofacial Surgery

2019

DOI: 10.1016/j.bjoms.2019.01.020

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Cleft and craniofacial surgery – how do we inspire and recruit the next generation of oral and maxillofacial surgeons?

Marnie Fullarton¹,

Chris Sweet

Ben Robertson

et al.

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Cited by 2 publications

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“…15 Finally, few clinicians and even fewer researchers work in the cleft and craniofacial field. 7 Clinical trials are notoriously expensive, time-consuming, and difficult to complete. 9 To compound the problem, up to half of clinical trial results never achieve publication.…”

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confidence: 99%

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Factors Affecting Outcomes of Craniofacial Clinical Trials

Halepas

Lee

Nwokeji

et al. 2021

Journal of Craniofacial Surgery

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This study aims to provide a cross-sectional view of craniofacial trials and to identify factors associated with completion, publication, and trial longevity. Materials and Methods: This is a cross-sectional study of cleft and craniofacial clinical trials registered with ClinicalTrials.gov between September 1999 and April 2020. Predictor variables included funding source, trial design, trial location, number of recruitment sites, and investigator specialty.Study outcomes were completion status, publication status, and trial duration. Univariate comparisons and multivariate regression models were calculated for each outcome. Results: The final sample included 179 clinical trials pertaining to craniofacial care. Nearly all trials were single-center (86.5%), and roughly half of trials were interventional (57.0%) or conducted in the United States (40.5%). No single specialty predominated, although plastic surgery (13.4%) was the most common investigator specialty. The completion rate was 82.7%, the publication rate was 40.8%, and the mean trial duration was 39.1 months. Interventional design (odds ratio ¼ 0.30, P ¼ 0.02) and United States location (odds ratio ¼ 0.15, P < 0.01) were each independently associated with lower odds of trial completion. Trial longevity was independently associated with the National Institute of Health-funding (P < 0.01) and multicenter design (P < 0.01). Conclusions: Craniofacial trials are multidisciplinary and have a high rate of completion. Although most existing trials were conducted at only a single-center, multicenter efforts significantly increased trial longevity without compromising completion and publication rates. Given the diverse array of conditions and lines of inquiry that compose craniofacial care, it is reassuring that collaboration did not negatively affect trial outcomes.

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confidence: 99%

“…Unlike other organ systems where animal models allow researchers to supplant human trials, the variability in midface anatomy does not always allow for a perfect animal-human match 15 . Finally, few clinicians and even fewer researchers work in the cleft and craniofacial field 7 …”

mentioning

confidence: 99%

Factors Affecting Outcomes of Craniofacial Clinical Trials

Halepas

Lee

Nwokeji

et al. 2021

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

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Cleft and craniofacial surgery training: is it time for a new solution for UK trainees?

Islam

2019

British Journal of Oral and Maxillofacial Surgery

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Cleft and craniofacial surgery – how do we inspire and recruit the next generation of oral and maxillofacial surgeons?

Cited by 2 publications

References 7 publications

Factors Affecting Outcomes of Craniofacial Clinical Trials

Factors Affecting Outcomes of Craniofacial Clinical Trials

Cleft and craniofacial surgery training: is it time for a new solution for UK trainees?

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