CLEC12B Is a Melanocytic Gene Regulating the Color of the Skin

Sormani, Laura; Montaudié, Henri; Blot, Lauriane; Heim, M; Leccia, Nathalie; Mhaidly, Rana; Verhoeyen, Els; Regazzetti, Claire; Nottet, Nicolas; Chéli, Yann; Donatis, Gian Marco De; Gay, Anne-Sophie; Debayle, Delphine; Martin, Hélène; Gesbert, Franck; Rocchi, Stéphane; Tulić, Meri K.; Passeron, Thierry

doi:10.1016/j.jid.2021.08.450

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…CLEC12B directly recruits and activates SHP1 and SHP2 through its immunoreceptor tyrosine-based inhibitory motif structural domain and promotes CRE CLEC12B , thereby ultimately controlling melanin production and hyperpigmentation in vitro and in reconstructed human epidermal models. The identification of CLEC12B in the melanocytes suggests that the C-type lectin receptor is involved in functions other than immunity and inflammation, and also provides insights into melanocyte biology and melanogenesis regulation [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study for Screening and Identifying Potential Shin Color Loci in Ducks

Guo

Jiang

Wang

et al. 2022

Genes

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Shin color diversity is a widespread phenomenon in birds. In this study, ducks were assessed to identify candidate genes for yellow, black, and spotted tibiae. For this purpose, we performed whole-genome resequencing of an F2 population consisting of 275 ducks crossed between Runzhou crested-white ducks and Cherry Valley ducks. We obtained 12.6 Mb of single nucleotide polymorphism (SNP) data, and the three shin colors were subsequently genotyped. Genome-wide association studies (GWASs) were performed to identify candidate and potential SNPs for the three shin colors. According to the results, 2947 and 3451 significant SNPs were associated with black and yellow shins, respectively, and six potential SNPs were associated with spotted shins. Based on the SNP annotations, the MITF, EDNRB2, POU family members, and the SLC superfamily were the candidate genes regulating pigmentation. In addition, the isoforms of EDNRB2, TYR, TYRP1, and MITF-M were significantly different between the black and yellow tibiae. MITF and EDNRB2 may have synergistic roles in the regulation of melanin synthesis, and their mutations may lead to phenotypic differences in the melanin deposition between individuals. This study provides new insights into the genetic factors that may influence tibia color diversity in birds.

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Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study for Screening and Identifying Potential Shin Color Loci in Ducks

Guo

Jiang

Wang

et al. 2022

Genes

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Biology of melanocytes in mammals

Cui,

Man

2023

Front. Cell Dev. Biol.

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Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for producing pigments and possessing a dendritic morphology. These cells migrate to the epidermis and follicles, contributing to skin and hair pigmentation during embryonic development. The remarkable self-renewal capacity of melanocytes enables them to effectively restore hair and skin pigmentation. The synthesis of melanin to safeguard the skin against damage caused by ultraviolet radiation, as well as the enigmatic immune function of melanocytes, demonstrate their indispensable contributions to maintaining cutaneous homeostasis. The regulation of cutaneous pigmentation involves an intricate network influenced by intrinsic cellular signals within melanocytes and extracellular cues. Therefore, this paper provides a comprehensive review of the role of melanocytes in skin biology. This in-depth analysis could open novel avenues for research aimed at the prevention and treatment of skin disorders.

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CLEC12B Is a Melanocytic Gene Regulating the Color of the Skin

Cited by 2 publications

References 21 publications

Genome-Wide Association Study for Screening and Identifying Potential Shin Color Loci in Ducks

Genome-Wide Association Study for Screening and Identifying Potential Shin Color Loci in Ducks

Biology of melanocytes in mammals

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